Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Elizabeth Keech"'
Autor:
B. K. Handa, Elizabeth Keech
Publikováno v:
International Journal of Peptide and Protein Research. 40:66-71
The synthesis of a substrate for the endothelin converting enzyme using the continuous flow FMOC solid phase method has been accomplished. The allyl group, employed to protect Glu side chain, was cleanly removed during the synthesis in the presence o
Autor:
E.A. Conway, D.N. Hurst, Elizabeth Keech, HA Overton, J.R. Greening, A.D. Campbell, Maria Grazia Carr, N.S. Jennings, R.M. Dunsdon, Tony M. Raynham, J.M. Bennett, C.S. Wilkinson, S. Jordan, F.X. Wilson, Paul S. Jones, KP Stenson, P.B. Kay, J. King-Underwood, Tci Wilkinson, Ggm Canning, B. K. Handa, M.A. O'Brien, Attwood
Publikováno v:
Scopus-Elsevier
Hepatitis C virus (HCV) is the cause of the majority of transfusion-associated hepatitis and a significant proportion of community-acquired hepatitis worldwide. Infection by HCV frequently leads to persistent infections that result in a range of clin
Autor:
Francis X. Wilson, Michael Richard Attwood, John R. Greening, Elizabeth Keech, Rachel M. Dunsdon, P. Jones, Balraj Krishnan Handa, Elizabeth A. Conway, Steven Jordan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:429-432
Important areas of a lead peptide inhibitor of IL-8 had been previously identified. Chemical modification led to the identification of key amide bonds which allowed the replacement of the central section of the peptide with modified amino acids and s
Autor:
Bette Mariani, James Klingler, Pritpal Singh, Maria Virginia Moncada, Elizabeth Keech, Ruth McDermott-Levy
Publikováno v:
GHTC
Two years ago, at the first IEEE Global Humanitarian Technology Conference, we presented a paper on the development of a tele-health project to provide a communication link to health care providers for the rural communities surrounding Waslala, a tow
Autor:
Gillian A. Bottomley, Elizabeth A. Conway, Irene Cowan, Michael Richard Attwood, Elizabeth Keech, Neera Borkakoti, Stephen J. Kirtland, Francis Xavier Wilson, P. Jones, Balraj Krishnan Handa, Amanda G. Fallowfield, Glyn Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1869-1874
Identification of the extracellular domains of the interleukin-8 (IL-8) receptor led to the synthesis of several peptide sequences. A peptide derived from a single subdomain was shown to inhibit IL-8 binding and to act as a functional antagonist. Ala
Publikováno v:
Antiviral Chemistry and Chemotherapy. 6:255-261
A fluorogenic peptide substrate for HCMV proteinase was synthesized by solid-phase peptide synthesis. The amino acid sequence of this substrate is derived from the maturation cleavage site (M site) of the natural substrate, the assembly protein precu
Publikováno v:
GHTC
In rural Nicaragua, access to health care professionals and medical facilities is limited. Minimally trained community health workers (CHWs) and understaffed clinical outposts serve rural communities. Rural residents rarely see a doctor except in eme
Publikováno v:
Tetrahedron Letters. 34:8361-8364
A palladium acetate mediated oxidative cyclisation has been used as the key step for the syntheses of staurosporine aglycone and related analogues.
Autor:
Colin C. F. Blake, Hans R. Hartmann, Michael J. Broadhurst, Elizabeth Keech, David J. Bushnell, Gareth John Thomas, Cedric H. Hassall, Nigel Adams, Alan R. Stratton
Publikováno v:
ChemInform. 22
A number of 4-demethoxyanthracyclines having hydroxylalkyl functions at the 9-position have previously been synthesized and shown to have potent antitumor activity. A series of carbamate derivatives of these (hydroxyalkyl)anthracyclines have now been
Autor:
David J. Bushnell, Hans R. Hartmann, Elizabeth Keech, Michael J. Broadhurst, Nigel Adams, Gareth John Thomas, Colin C. F. Blake, Alan R. Stratton, Cedric H. Hassall
Publikováno v:
ChemInform. 22
A versatile and efficient synthetic route to 4-demethoxyanthracyclinones has been utilized in the preparation of a number of aglycons having 9-alkyl, 9-(hydroxylalkyl), or 9-carbamoyl substituents. Silver trifluoromethanesulfonate catalyzed coupling