Výsledky vyhledávání - "Elizabeth K. Mazsa"

Data from Neuregulin 1 Expression Is a Predictive Biomarker for Response to AV-203, an ERBB3 Inhibitory Antibody, in Human Tumor Models

Autor: Zhigang Weng, Jeno Gyuris, Bin Feng, Solly Weiler, William M. Winston, Richard Nicoletti, Donna McIntosh, Steve Bottega, Andrea R. Delpero, Elizabeth K. Mazsa, Steven Tyler, Sylvie Vincent, Kristan Meetze

Purpose: ERBB3 is overexpressed in a broad spectrum of human cancers, and its aberrant activation is associated with tumor pathogenesis and therapeutic resistance to various anticancer agents. Neuregulin 1 (NRG1) is the predominant ligand for ERBB3 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240ee4a4dbec7cb9f7fdbfbb64ce1f8b
https://doi.org/10.1158/1078-0432.c.6524480

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Supplementary Figures 1 - 4, Tables 1 - 2 from Neuregulin 1 Expression Is a Predictive Biomarker for Response to AV-203, an ERBB3 Inhibitory Antibody, in Human Tumor Models

Supplementary Table 1. The contingency table for the Fisherâ€™s exact test for xenograft models used in the study. Supplementary Table 2. NRG1 and ERBB3 expression in human cancers from TCGA database. Supplementary Figure 1. Effect of AV-203 on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0d1aa9b33c2f6c00a4324f2e4fee14
https://doi.org/10.1158/1078-0432.22460390.v1

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Supplementary Materials and Methods, Figure Legends from Neuregulin 1 Expression Is a Predictive Biomarker for Response to AV-203, an ERBB3 Inhibitory Antibody, in Human Tumor Models

Supplementary Materials and Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f1ef7db0a1f43f27fc4ca7d2cdf494
https://doi.org/10.1158/1078-0432.22460387.v1

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Supplementary Methods, Figure Legends 1-4 from GP369, an FGFR2-IIIb–Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Autor: Zhigang Weng, Jeno Gyuris, Lorena Lerner, Jinwei Jiang, Nesreen S. Ismail, Ting Chen, Laura L. Poling, Solly Weiler, William M. Winston, Elizabeth K. Mazsa, Sriram Kollipara, Nhi Y. Vo, Kristan Meetze, Ailin Bai

Supplementary Methods, Figure Legends 1-4 from GP369, an FGFR2-IIIb–Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::592eacaff02ff14ea5495a04e0a0e623
https://doi.org/10.1158/0008-5472.22385274.v1

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Data from GP369, an FGFR2-IIIb–Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Dysregulated fibroblast growth factor (FGF) signaling has been implicated in the pathogenesis of human cancers. Aberrant activation of FGF receptor 2 (FGFR2) signaling, through overexpression of FGFR2 and/or its ligands, mutations, and receptor ampli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357a069f26f08a0fbdca3220b5242c6b
https://doi.org/10.1158/0008-5472.c.6501174

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Supplementary Figures 1-4 from GP369, an FGFR2-IIIb–Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Supplementary Figures 1-4 from GP369, an FGFR2-IIIb–Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1945bc4134ce8b51d5d5d2949409d3
https://doi.org/10.1158/0008-5472.22385277

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MAP3K11/GDF15 axis is a critical driver of cancer cachexia

Autor: Brian Krieger, Richard Nicoletti, Qing Liu, Julie Tao, Ruoji Wang, Jie Lin, Zakir Siddiquee, Luhua Shen, Bin Feng, Solly Weiler, Elizabeth K. Mazsa, M. Isabel Chiu, Zhigang Weng, Lorena Lerner, Lucia Huang, Jeno Gyuris, William Winston, Antonio Vigano

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle. 7:467-482

Background Cancer associated cachexia affects the majority of cancer patients during the course of the disease and thought to be directly responsible for about a quarter of all cancer deaths. Current evidence suggests that a pro-inflammatory state ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e9e2e6e331c64e55a9910d78219976f9
https://doi.org/10.1002/jcsm.12077

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GP369, an FGFR2-IIIb–Specific Antibody, Exhibits Potent Antitumor Activity against Human Cancers Driven by Activated FGFR2 Signaling

Autor: Ailin Bai, William Winston, Laura L. Poling, Ting Chen, Solly Weiler, Jinwei Jiang, Nesreen Ismail, Kristan Meetze, Nhi Y. Vo, Elizabeth K. Mazsa, Zhigang Weng, Lorena Lerner, Jeno Gyuris, Sriram Kollipara

Publikováno v: Cancer Research. 70:7630-7639

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa854de7b8d8e628d5e3972ad61d13a
https://doi.org/10.1158/0008-5472.can-10-1489

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Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models

Autor: Elizabeth K. Mazsa, Zhigang Weng, Andrea R Delpero, William Winston, Bin Feng, Sylvie Vincent, Jeno Gyuris, Kristan Meetze, Steve Bottega, Solly Weiler, Steven Tyler, Donna McIntosh, Richard Nicoletti

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 21(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d9abeb6ff0ea377c99ed7c469a6e01
https://pubmed.ncbi.nlm.nih.gov/25542901

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