Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elizabeth K. Leffel"'
Autor:
Adriana Amaro, Giovanna Angelini, Laurent Audoly, Pierre Ferré, Parviz Ghahramani, Dimitris Kalaitzopoulos, Ross D. LeClaire, Elizabeth K. Leffel, Alexandre Passioukov, Ketan Patel, Andrea Petretto, Ulrich Pfeffer, Benedikte Serruys, Thomas Stöhr, Hans Ulrichts, Maarten Van Roy, Katrien Vanheusden, Gabriel Vargas, Stephen Wood, Erfan Younesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbb77ef0b3017392ae995f5852f89736
https://doi.org/10.1016/b978-0-12-803460-6.01002-3
https://doi.org/10.1016/b978-0-12-803460-6.01002-3
Autor:
Ross D. LeClaire, Elizabeth K. Leffel
for Section 1: Regulatory Process in the United States of America In the United States (US), the drug approval process is governed by the Food and Drug Administration (FDA). This agency is mandated by law to ensure that every medical product marketed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d3a711cc6a22afa2b8a4337e49bceb4
https://doi.org/10.1016/b978-0-12-803460-6.00005-2
https://doi.org/10.1016/b978-0-12-803460-6.00005-2
Autor:
Robert W. Hepler, Arthur M. Friedlander, Michael J. Caulfield, Wesley Shoop, Louise Pitt, Wilson J. Ribot, Su Wang, Nicholas J. Vietri, Gordon Ruthel, Elizabeth K. Leffel, Donald J. Chabot, Joseph G. Joyce, James C. Cook
Publikováno v:
Vaccine. 30:846-852
Bacillus anthracis, the causative agent of anthrax, is recognized as one of the most serious bioterrorism threats. The current human vaccines are based on the protective antigen component of the anthrax toxins. Concern about possible vaccine resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f156a3982d5521283045125b1ec89259
https://doi.org/10.1016/j.vaccine.2011.12.010
https://doi.org/10.1016/j.vaccine.2011.12.010
Autor:
Nancy A. Twenhafel, Bruce E. Ivins, Mary E. Wright, Suzanne L. Rasmussen, Wendy M. Webster, Nicholas J. Vietri, Steven A. Tobery, Arthur M. Friedlander, Mark D. Kellogg, Bret K. Purcell, Elizabeth K. Leffel
Publikováno v:
The Journal of Infectious Diseases. 199:336-341
Background Postexposure prophylaxis of inhalational anthrax requires prolonged antibiotic therapy or antibiotics and vaccination. The duration of treatment for established anthrax is controversial, because retained spores may germinate and cause dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcb093d5bc8bada6b117dc0b4719eea9
https://doi.org/10.1086/596063
https://doi.org/10.1086/596063
Autor:
Elizabeth K. Leffel, Bret K. Purcell, Sina Bavari, Teresa G. Abshire, Arthur M. Friedlander, John W. Ezzell, Wilson J. Ribot, Donald J. Chabot, Rekha G. Panchal
Publikováno v:
Infection and Immunity. 77:749-755
Bacillus anthracis lethal toxin (LT) was characterized in plasma from infected African Green monkeys, rabbits, and guinea pigs. In all cases, during the terminal phase of infection only the protease-activated 63-kDa form of protective antigen (PA 63
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d15e521063d021a1c73618ce1db21b
https://doi.org/10.1128/iai.00764-08
https://doi.org/10.1128/iai.00764-08
Autor:
Sarah L. Norris, Cynthia A. Rossi, Melanie Ulrich, Louise Pitt, Elizabeth K. Leffel, Douglas S. Reed
Publikováno v:
Infection and Immunity. 76:5790-5801
In 2001, a bioterrorism attack involving Bacillus anthracis spore-laced letters resulted in 22 cases of inhalation anthrax, with five fatalities. This incident identified gaps in our health care system and precipitated a renewed interest in identifyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfeed6720199e5ed9290d06332798a0b
https://doi.org/10.1128/iai.00520-08
https://doi.org/10.1128/iai.00520-08
Publikováno v:
Veterinary Pathology. 44:716-721
There is a critical need for an alternative nonhuman primate model for inhalational anthrax infection because of the increasingly limited supply and cost of the current model. This report describes the pathology in 12 African green monkeys (AGMs) tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3479d8a102e55c24ca96666853e6ef55
https://doi.org/10.1354/vp.44-5-716
https://doi.org/10.1354/vp.44-5-716
Autor:
Hongxia Fan, Rosemarie Kelly, Andrea Woods, Hugh A. George, Tessie McNeely, Maria C Losada, Leslie Cope, Kathrin U. Jansen, Joseph G. Joyce, Paul M. Keller, Xiaorong Wei, Myra B. Kurtz, Louise Pitt, Loren D. Schultz, Elizabeth K. Leffel, Robert W. Hepler, Alka Bansal, James C. Cook, Steven L. Cohen, Gina Zang
Publikováno v:
Vaccine. 24:1501-1514
Infection by Bacillus anthracis is preventable by prophylactic vaccination with several naturally derived and recombinant vaccine preparations. Existing data suggests that protection is mediated by antibodies directed against the protective antigen (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab67d670a510c0f8fe74aa4fce6cc62
https://doi.org/10.1016/j.vaccine.2005.10.018
https://doi.org/10.1016/j.vaccine.2005.10.018
Publikováno v:
Toxicology. 188:233-250
Cadmium is a pervasive environmental contaminant. The primary route of exposure to the general population occurs via contaminated drinking water or food supplies. Our hypothesis was that cadmium could be a trigger for inducing autoimmune disease (AD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61be0ef38d81fb23d4dddfeee2ef5521
https://doi.org/10.1016/s0300-483x(03)00092-1
https://doi.org/10.1016/s0300-483x(03)00092-1
Autor:
Tai L. Guo, Kimber L. White, J. Ann McCay, Dori R. Germolec, Ling X. Zhang, Elizabeth K. Leffel, N. A. Karrow
Publikováno v:
American Journal of Contact Dermatitis. 12:6-17
Background: Although the Murine Local Lymph Node Assay (LLNA) is efficient in identifying chemicals with sensitizing potential, there is increasing need for alternative end points. Cinnamaldehyde (CIN) was chosen for evaluation based on its moderate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d491d3ea87dfca19634cd7eb3103caa1
https://doi.org/10.1053/ajcd.2001.0120006
https://doi.org/10.1053/ajcd.2001.0120006