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pro vyhledávání: '"Elizabeth K Huh"'
Autor:
Sergey A. Vishnivetskiy, Elizabeth K. Huh, Preethi C. Karnam, Samantha Oviedo, Eugenia V. Gurevich, Vsevolod V. Gurevich
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 22, p 13887 (2022)
Arrestins preferentially bind active phosphorylated G protein-coupled receptors (GPCRs). The middle loop, highly conserved in all arrestin subtypes, is localized in the central crest on the GPCR-binding side. Upon receptor binding, it directly intera
Externí odkaz:
https://doaj.org/article/bd79a96ca40a4952b91ac67c2dbe8ce3
Publikováno v:
J Neurochem
The finger loop in the central crest of the receptor-binding side of arrestins engages the cavity between the transmembrane helices of activated G protein-coupled receptors. Therefore, it was hypothesized to serve as the sensor that detects the activ