Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Elizabeth K, Speliotes"'
Autor:
Samuel K. Handelman, Yindra M. Puentes, Annapurna Kuppa, Yanhua Chen, Xiaomeng Du, Mary F. Feitosa, Nicholette D. Palmer, Elizabeth K. Speliotes
Publikováno v:
Hepatology Communications, Vol 6, Iss 11, Pp 3120-3131 (2022)
Abstract Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide. NAFLD is associated with elevated serum triglycerides (TG), low‐density lipoprotein cholesterol (LDL), and reduced high‐density lipoprotein cholesterol (HDL). Both NAFLD an
Externí odkaz:
https://doaj.org/article/6137dffe57de48ee805a74226afa396a
Autor:
Vincent L. Chen, Xiaomeng Du, Yanhua Chen, Annapurna Kuppa, Samuel K. Handelman, Rishel B. Vohnoutka, Patricia A. Peyser, Nicholette D. Palmer, Lawrence F. Bielak, Brian Halligan, Elizabeth K. Speliotes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/849fa0e898b04f6c9fd837bc969d67d0
Autor:
Vincent L. Chen, Daniel A. Burkholder, Isabel J. Moran, Jacob V. DiBattista, Matthew J. Miller, Yanhua Chen, Xiaomeng Du, Antonino Oliveri, Kelly C. Cushing, Anna S. Lok, Elizabeth K. Speliotes
Publikováno v:
JHEP Reports, Vol 4, Iss 6, Pp 100483- (2022)
Background & Aims: Alpha-1 antitrypsin deficiency is caused by mutations in SERPINA1, most commonly homozygosity for the Pi∗Z variant, and can present as liver disease. While heterozygosity for Pi∗Z (Pi∗MZ) is linked to increased risk of cirrho
Externí odkaz:
https://doaj.org/article/999661784190473a98decd71984b6b0f
Autor:
Vincent L. Chen, Xiaomeng Du, Yanhua Chen, Annapurna Kuppa, Samuel K. Handelman, Rishel B. Vohnoutka, Patricia A. Peyser, Nicholette D. Palmer, Lawrence F. Bielak, Brian Halligan, Elizabeth K. Speliotes
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Serum liver enzyme concentrations are the most frequently-used laboratory markers of liver disease, a major cause of mortality. We conduct a meta-analysis of genome-wide association studies of liver enzymes from UK BioBank and BioBank Japan.
Externí odkaz:
https://doaj.org/article/83b170469b994a178b736003c46c40b3
Autor:
Zixuan Zhang, Kimberley Burrows, Harriett Fuller, Elizabeth K. Speliotes, Kushala W. M. Abeysekera, James L. Thorne, Sarah J. Lewis, Michael A. Zulyniak, J. Bernadette Moore
Publikováno v:
Nutrients, Vol 15, Iss 6, p 1442 (2023)
Evidence for a role for vitamin D in non-alcoholic fatty liver disease (NAFLD) pathogenesis is conflicting. As Mendelian randomisation (MR) avoids many limitations of conventional observational studies, this two-sample bidirectional MR analysis was c
Externí odkaz:
https://doaj.org/article/dfc6f2014fea4812a3321d0d36e605ea
Autor:
Vincent L. Chen, Andrew P. Wright, Brian Halligan, Yanhua Chen, Xiaomeng Du, Samuel K. Handelman, Michelle T. Long, Douglas P. Kiel, Elizabeth K. Speliotes
Publikováno v:
Hepatology Communications, Vol 3, Iss 8, Pp 1073-1084 (2019)
Up to 25% of patients with nonalcoholic fatty liver disease (NAFLD) are not obese but may have a fat or muscle composition that predisposes them to NAFLD. Our aim was to determine whether body composition parameters associate with NAFLD and to identi
Externí odkaz:
https://doaj.org/article/19e61050ca364b1f8df88f5b08129c99
Autor:
Llilda Barata, Mary F. Feitosa, Lawrence F. Bielak, Brian Halligan, Abigail S. Baldridge, Xiuqing Guo, Laura M. Yerges‐Armstrong, Albert V. Smith, Jie Yao, Nicholette D. Palmer, Lisa B. VanWagner, J. Jeffrey Carr, Yii‐Der I. Chen, Matthew Allison, Matthew J. Budoff, Samuel K. Handelman, Sharon L.R. Kardia, Thomas H. Mosley Jr., Kathleen Ryan, Tamara B. Harris, Lenore J. Launer, Vilmundur Gudnason, Jerome I. Rotter, Myriam Fornage, Laura J. Rasmussen‐Torvik, Ingrid B. Borecki, Jeffrey R. O’Connell, Patricia A. Peyser, Elizabeth K. Speliotes, Michael A. Province
Publikováno v:
Hepatology Communications, Vol 3, Iss 7, Pp 894-907 (2019)
The accumulation of excess fat in the liver (hepatic steatosis) in the absence of heavy alcohol consumption causes nonalcoholic fatty liver disease (NAFLD), which has become a global epidemic. Identifying metabolic risk factors that interact with the
Externí odkaz:
https://doaj.org/article/dc2254708827499b9d5d2caf45709248
Autor:
Kelly C Cushing, Yanhua Chen, Xiaomeng Du, Vincent Chen, Annapurna Kuppa, Peter Higgins, Elizabeth K Speliotes
Publikováno v:
Inflammatory Bowel Diseases. 29:938-945
Background Inflammatory bowel disease (IBD) is associated with an increased risk of osteoporosis and bone fracture. The aims of this study were to (1) confirm the association between IBD and low bone density and (2) test for shared risk variants acro
Autor:
Samuel K. Handelman, Yindra M. Puentes, Annapurna Kuppa, Yanhua Chen, Xiaomeng Du, Mary F. Feitosa, Nicholette D. Palmer, Elizabeth K. Speliotes
Publikováno v:
Hepatology Communications. 6:3120-3131
Nonalcoholic fatty liver disease (NAFLD) is prevalent worldwide. NAFLD is associated with elevated serum triglycerides (TG), low-density lipoprotein cholesterol (LDL), and reduced high-density lipoprotein cholesterol (HDL). Both NAFLD and blood lipid
Autor:
Asmita Pant, Yue Chen, Annapurna Kuppa, Xiaomeng Du, Brian D. Halligan, Elizabeth K. Speliotes
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9758 (2021)
Non-alcoholic fatty liver disease (NAFLD) is caused by excess lipid accumulation in hepatocytes. Genome-wide association studies have identified a strong association of NAFLD with non-synonymous E167K amino acid mutation in the transmembrane 6 superf
Externí odkaz:
https://doaj.org/article/cb5d100ae4854a7ca6309640ebdf6b5f