Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Elizabeth Jaworski"'
Autor:
Mauro Montalbano, Elizabeth Jaworski, Stephanie Garcia, Anna Ellsworth, Salome McAllen, Andrew Routh, Rakez Kayed
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Tau protein is a known contributor in several neurodegenerative diseases, including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). It is well-established that tau forms pathological aggregates and fibrils in these diseases. Tau has bee
Externí odkaz:
https://doaj.org/article/e82630aa9dc645a094f19b3dcebd97b6
Autor:
Jun Cao, Sunil K. Verma, Elizabeth Jaworski, Stephanie Mohan, Chloe K. Nagasawa, Kempaiah Rayavara, Amanda Sooter, Sierra N. Miller, Richard J. Holcomb, Mason J. Powell, Ping Ji, Nathan D. Elrod, Eda Yildirim, Eric J. Wagner, Vsevolod Popov, Nisha J. Garg, Andrew L. Routh, Muge N. Kuyumcu-Martinez
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109910- (2021)
Summary: RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases. However, it is unclear whether RBFOX2 has other roles in RNA processing that can influence gene expression in muscle cells, contributing to heart
Externí odkaz:
https://doaj.org/article/1c3849ba190a44869afb25b4370a9f1a
Autor:
Elizabeth Jaworski, Rose M Langsjoen, Brooke Mitchell, Barbara Judy, Patrick Newman, Jessica A Plante, Kenneth S Plante, Aaron L Miller, Yiyang Zhou, Daniele Swetnam, Stephanea Sotcheff, Victoria Morris, Nehad Saada, Rafael RG Machado, Allan McConnell, Steven G Widen, Jill Thompson, Jianli Dong, Ping Ren, Rick B Pyles, Thomas G Ksiazek, Vineet D Menachery, Scott C Weaver, Andrew L Routh
Publikováno v:
eLife, Vol 10 (2021)
High-throughput genomics of SARS-CoV-2 is essential to characterize virus evolution and to identify adaptations that affect pathogenicity or transmission. While single-nucleotide variations (SNVs) are commonly considered as driving virus adaption, RN
Externí odkaz:
https://doaj.org/article/4d7ebe7fd8ba48a3ba01181583b2b50c
Autor:
Stephanea L. Sotcheff, John Yun-Chung Chen, Nathan Elrod, Jun Cao, Elizabeth Jaworski, Mugé N. Kuyumcu-Martinez, Pei-Yong Shi, Andrew L. Routh
Publikováno v:
Pathogens, Vol 11, Iss 8, p 936 (2022)
Flaviviruses are small RNA viruses that are mainly transmitted via arthropod vectors and are found in tropic and sub-tropical regions. Most infections are asymptomatic (90–95%), but symptoms can be as severe as hemorrhagic fever and encephalitis. O
Externí odkaz:
https://doaj.org/article/7d6a1038bd204cb69ef29048e3090e98
A Low Fidelity Virus Shows Increased Recombination during the Removal of an Alphavirus Reporter Gene
Publikováno v:
Viruses, Vol 12, Iss 6, p 660 (2020)
Reporter genes for RNA viruses are well-known to be unstable due to putative RNA recombination events that excise inserted nucleic acids. RNA recombination has been demonstrated to be co-regulated with replication fidelity in alphaviruses, but it is
Externí odkaz:
https://doaj.org/article/3d406cbfae574e219fdce0ec57317b2c
Autor:
Elizabeth Jaworski, Andrew Routh
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006365 (2017)
Defective-Interfering RNAs (DI-RNAs) have long been known to play an important role in virus replication and transmission. DI-RNAs emerge during virus passaging in both cell-culture and their hosts as a result of non-homologous RNA recombination. How
Externí odkaz:
https://doaj.org/article/1e210739f6d2411290f9791d2a363442
Autor:
Fatah Kashanchi, Kylene Kehn-Hall, Aarthi Narayanan, Zachary Klase, Elizabeth Jaworski, Ravi Das, Irene Guendel, Gavin C. Sampey
Publikováno v:
Biology, Vol 1, Iss 2, Pp 339-369 (2012)
Gene silencing via non-coding RNA, such as siRNA and miRNA, can occur at the transcriptional, post-transcriptional, and translational stages of expression. Transcriptional gene silencing (TGS) involving the RNAi machinery generally occurs through DNA
Externí odkaz:
https://doaj.org/article/677a8eec7a73409b97f72557637df71e
Autor:
Elizabeth Jaworski, Mohammed Saifuddin, Gavin Sampey, Nazly Shafagati, Rachel Van Duyne, Sergey Iordanskiy, Kylene Kehn-Hall, Lance Liotta, Emanuel Petricoin, Mary Young, Benjamin Lepene, Fatah Kashanchi
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96778 (2014)
HIV-1 infection results in a chronic but incurable illness since long-term HAART can keep the virus to an undetectable level. However, discontinuation of therapy rapidly increases viral burden. Moreover, patients under HAART frequently develop variou
Externí odkaz:
https://doaj.org/article/3794c6c13cbd47c3a00cb04e7d574595
Autor:
Rachel Van Duyne, Irene Guendel, Zachary Klase, Aarthi Narayanan, William Coley, Elizabeth Jaworski, Jessica Roman, Anastas Popratiloff, Renaud Mahieux, Kylene Kehn-Hall, Fatah Kashanchi
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40662 (2012)
The innate ability of the human cell to silence endogenous retroviruses through RNA sequences encoding microRNAs, suggests that the cellular RNAi machinery is a major means by which the host mounts a defense response against present day retroviruses.
Externí odkaz:
https://doaj.org/article/8881e5cfb3a6451789826816022e8d18
Autor:
Tomas Patrich, Yaqun Wang, Mohamed A. Elshaikh, Simeng Zhu, Shari Damast, Jessie Y. Li, Emma C. Fields, Sushil Beriwal, Andrew Keller, Elizabeth A. Kidd, Melissa Usoz, Shruti Jolly, Elizabeth Jaworski, Eric W. Leung, Neil K. Taunk, Junzo Chino, Andrea L. Russo, Jayanthi S. Lea, Larissa J. Lee, Kevin V. Albuquerque, Lara Hathout
Publikováno v:
American Journal of Clinical Oncology. 46:114-120