Bed‐rest and exercise remobilization: Concurrent adaptations in muscle glucose and protein metabolism

Autor: Natalie F. Shur, Elizabeth J. Simpson, Hannah Crossland, Despina Constantin, Sally M. Cordon, Dumitru Constantin‐Teodosiu, Francis B. Stephens, Matthew S. Brook, Philip J. Atherton, Kenneth Smith, Daniel J. Wilkinson, Olivier E. Mougin, Christopher Bradley, Ian A. Macdonald, Paul L. Greenhaff

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 2, Pp 603-614 (2024)

Abstract Background Bed‐rest (BR) of only a few days duration reduces muscle protein synthesis and induces skeletal muscle atrophy and insulin resistance, but the scale and juxtaposition of these events have not been investigated concurrently in th

Externí odkaz: https://doaj.org/article/d580a30a9b8542378951c31db57ce3e4

Human adaptation to immobilization: Novel insights of impacts on glucose disposal and fuel utilization

Autor: Natalie F. Shur, Elizabeth J. Simpson, Hannah Crossland, Prince K. Chivaka, Despina Constantin, Sally M. Cordon, Dumitru Constantin‐Teodosiu, Francis B. Stephens, Dileep N. Lobo, Nate Szewczyk, Marco Narici, Clara Prats, Ian A. Macdonald, Paul L. Greenhaff

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 6, Pp 2999-3013 (2022)

Abstract Background Bed rest (BR) reduces whole‐body insulin‐stimulated glucose disposal (GD) and alters muscle fuel metabolism, but little is known about metabolic adaptation from acute to chronic BR nor the mechanisms involved, particularly whe

Externí odkaz: https://doaj.org/article/f97e7068eb4841f7aac80e318d3cdd0f

Cocoa Flavanol Supplementation and the Effect on Insulin Resistance in Females Who Are Overweight or Obese: A Randomized, Placebo-Controlled Trial

Autor: Elizabeth J. Simpson, Buddhike Mendis, Mandy Dunlop, Hagen Schroeter, Catherine Kwik-Uribe, Ian A. Macdonald

Publikováno v: Nutrients, Vol 15, Iss 3, p 565 (2023)

There is interest in the impact that dietary interventions can have on preventing the transition from insulin resistance to type 2 diabetes, including a suggestion that the bioactive components of cocoa may enhance fasting insulin sensitivity. Howeve

Externí odkaz: https://doaj.org/article/665e7603bcca4bfba254d601abe7f5ff

What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study

Autor: Angelo Tremblay, Mikael Fogelholm, Elli Jalo, Margriet S. Westerterp-Plantenga, Tanja C. Adam, Maija Huttunen-Lenz, Gareth Stratton, Tony Lam, Teodora Handjieva-Darlenska, Svetoslav Handjiev, J. Alfredo Martinez, Ian A. Macdonald, Elizabeth J. Simpson, Jennie Brand-Miller, Roslyn Muirhead, Sally D. Poppitt, Marta P. Silvestre, Thomas M. Larsen, Pia Siig Vestentoft, Wolfgang Schlicht, Vicky Drapeau, Anne Raben

Publikováno v: Frontiers in Nutrition, Vol 8 (2021)

This study was performed to evaluate the profile of overweight individuals with pre-diabetes enrolled in PREVIEW who were unable to achieve a body weight loss of ≥8% of the baseline value in response to a 2-month low-energy diet (LED). Their baseli

Externí odkaz: https://doaj.org/article/e493f1e14d4a4d39ac359759bb50dfa4

The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males

Autor: William V. Trim, Jean-Philippe Walhin, Francoise Koumanov, James E. Turner, Natalie F. Shur, Elizabeth J. Simpson, Ian A. Macdonald, Paul L. Greenhaff, Dylan Thompson

Publikováno v: Trim, W, Walhin, J-P, Koumanov, F, Turner, J, Shur, N, Simpson, E, Macdonald, I, Greenhaff, P & Thompson, D 2023, ' The impact of physical inactivity on glucose homeostasis when diet is adjusted to maintain energy balance in healthy, young males ', Clinical Nutrition, vol. 42, no. 2023, pp. 532-540 . https://doi.org/10.1016/j.clnu.2023.02.006

Background & Aims: It is unclear if dietary adjustments to maintain energy balance during reduced physical activity can offset inactivity-induced reductions in insulin sensitivity and glucose disposal to produce normal daily glucose concentrations an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3c62142b7ac7a18aa5698b3a3d6feb0
https://doi.org/10.1016/j.clnu.2023.02.006