Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Elizabeth J. Rideout"'
Autor:
Celena M. Cherian, Hayley R. Reeves, Duneesha De Silva, Serena Tsao, Katie E. Marshall, Elizabeth J. Rideout
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Background Sex differences exist in the risk of developing type 1 and type 2 diabetes, and in the risk of developing diabetes-associated complications. Sex differences in glucose homeostasis, islet and β cell biology, and peripheral insulin
Externí odkaz:
https://doaj.org/article/aca5ec7f1d6446938944332bd9cf1b8c
Autor:
George P. Brownrigg, Yi Han Xia, Chieh Min Jamie Chu, Su Wang, Charlotte Chao, Jiashuo Aaron Zhang, Søs Skovsø, Evgeniy Panzhinskiy, Xiaoke Hu, James D. Johnson, Elizabeth J. Rideout
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101678- (2023)
Objective: Pancreatic β cells play a key role in maintaining glucose homeostasis; dysfunction of this critical cell type causes type 2 diabetes (T2D). Emerging evidence points to sex differences in β cells, but few studies have examined male-female
Externí odkaz:
https://doaj.org/article/374b1790b35f4f059d15bf42060d49ea
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Autor:
Anni M. Y. Zhang, Ken H. Chu, Brian F. Daly, Titine Ruiter, Yan Dou, Jenny C. C. Yang, Twan J. J. de Winter, Justin Chhuor, Su Wang, Stephane Flibotte, Yiwei Bernie Zhao, Xiaoke Hu, Hong Li, Elizabeth J. Rideout, David F. Schaeffer, James D. Johnson, Janel L. Kopp
Publikováno v:
Cancer & Metabolism, Vol 10, Iss 1, Pp 1-18 (2022)
Abstract Background Hyperinsulinemia is independently associated with increased risk and mortality of pancreatic cancer. We recently reported that genetically reduced insulin production resulted in ~ 50% suppression of pancreatic intraepithelial neop
Externí odkaz:
https://doaj.org/article/ff9b541c39684bccacb601c1a9c7f635
Publikováno v:
eLife, Vol 10 (2021)
Sex differences in whole-body fat storage exist in many species. For example, Drosophila females store more fat than males. Yet, the mechanisms underlying this sex difference in fat storage remain incompletely understood. Here, we identify a key role
Externí odkaz:
https://doaj.org/article/7bc2ec54bb52409b98ea317a2bbff5e5
Autor:
Jason W Millington, George P Brownrigg, Charlotte Chao, Ziwei Sun, Paige J Basner-Collins, Lianna W Wat, Bruno Hudry, Irene Miguel-Aliaga, Elizabeth J Rideout
Publikováno v:
eLife, Vol 10 (2021)
Nutrient-dependent body size plasticity differs between the sexes in most species, including mammals. Previous work in Drosophila showed that body size plasticity was higher in females, yet the mechanisms underlying increased female body size plastic
Externí odkaz:
https://doaj.org/article/87937031a5ad4c95a74d6993ab80b4a4
Autor:
Laura N Stankiewicz, Kevin Salim, Emily A Flaschner, Yu Xin Wang, John M Edgar, Bruce ZB Lin, Grace C Bingham, Matthew C Major, Ross D Jones, Helen M Blau, Elizabeth J Rideout, Megan K Levings, Peter W Zandstra, Fabio MV Rossi
Publikováno v:
bioRxiv
SummaryWithin the thymus, regulation of the cellular cross-talk directing T cell development is dependent on spatial interactions within specialized niches. To create a holistic, spatially defined map of tissue niches guiding postnatal T cell develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c7bca0c46114847f2a5ad4602946ecd
https://doi.org/10.1101/2023.04.13.536804
https://doi.org/10.1101/2023.04.13.536804
Autor:
Charlotte F. Chao, Yanina-Yasmin Pesch, Huaxu Yu, Chenjingyi Wang, Maria Aristizabal, Tao Huan, Guy Tanentzapf, Elizabeth J. Rideout
Drosophilais a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to normal sperm development is largely unknown. Emerging ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c7ceec8f6a6ee5eaad9b7167e8fa40
https://doi.org/10.1101/2022.12.16.520841
https://doi.org/10.1101/2022.12.16.520841
Autor:
George P. Brownrigg, Yi Han Xia, Chieh Min Jamie Chu, Su Wang, Charlotte Chao, Jiashuo Aaron Zhang, Søs Skovsø, Evgeniy Panzhinskiy, Xiaoke Hu, James D. Johnson, Elizabeth J. Rideout
ObjectivePancreatic β cells play a key role in glucose homeostasis; dysfunction of this critical cell type causes type 2 diabetes (T2D). Emerging evidence points to sex differences in β cells, but few studies have examined male-female differences i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f53926326a694a9ff92ed282095555a5
https://doi.org/10.1101/2022.05.10.491428
https://doi.org/10.1101/2022.05.10.491428
Autor:
Anni M.Y. Zhang, Yi Han Xia, Jeffrey S.H. Lin, Ken H. Chu, Titine J.J. Ruiter, Jenny C.C. Yang, Nan Chen, Justin Chhuor, Shilpa Patil, Haoning Howard Cen, Elizabeth J. Rideout, Vincent R. Richard, David F. Schaeffer, Rene P. Zahedi, Christoph H. Borchers, James D. Johnson, Janel L. Kopp
The rising incidence of pancreatic cancer is largely driven by the skyrocketing prevalence of obesity and type 2 diabetes (T2D). Hyperinsulinemia is a cardinal feature of both conditions, and is independently associated with increased cancer incidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb6d2d36d9f0fbabbdbc8b5fdd8e905
https://doi.org/10.1101/2022.05.06.490845
https://doi.org/10.1101/2022.05.06.490845