Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elizabeth J. Millings"'
Autor:
Elizabeth J Millings, Maria Caterina De Rosa, Sarah Fleet, Kazuhisa Watanabe, Richard Rausch, Dieter Egli, Gen Li, Charles A Leduc, Yiying Zhang, Stuart G Fischer, Rudolph L Leibel
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197548 (2018)
We have previously reported that Ildr2 knockdown via adenovirally-delivered shRNA causes hepatic steatosis in mice. In the present study we investigated hepatic biochemical and anatomic phenotypes of Cre-mediated Ildr2 knock-out mice. Liver-specific
Externí odkaz:
https://doaj.org/article/66d806134ca748b497d61b5b6864b91d
Autor:
Suzanne G. Mays, Emma H. D’Agostino, Autumn R. Flynn, Xiangsheng Huang, Guohui Wang, Xu Liu, Elizabeth J. Millings, C. Denise Okafor, Anamika Patel, Michael L. Cato, Jeffery L. Cornelison, Diana Melchers, René Houtman, David D. Moore, John W. Calvert, Nathan T. Jui, Eric A. Ortlund
Publikováno v:
Cell chemical biology. 29(7)
Phospholipids are ligands for nuclear hormone receptors (NRs) that regulate transcriptional programs relevant to normal physiology and disease. Here, we demonstrate that mimicking phospholipid-NR interactions is a robust strategy to improve agonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f616c6aeb0c235f6c5823f5c90ffb0f2
https://pubmed.ncbi.nlm.nih.gov/35316658
https://pubmed.ncbi.nlm.nih.gov/35316658
Autor:
Kazuhisa Watanabe, Elizabeth Watson, Maria Laura Cremona, Elizabeth J Millings, Jay H Lefkowitch, Stuart G Fischer, Charles A LeDuc, Rudolph L Leibel
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67234 (2013)
Ildr2, a modifier of diabetes susceptibility in obese mice, is expressed in most organs, including islets and hypothalamus, with reduced levels in livers of diabetes-susceptible B6.DBA mice congenic for a 1.8 Mb interval of Chromosome 1. In hepatoma
Externí odkaz:
https://doaj.org/article/404c84fb376d47839b7f217b0be66723
Autor:
Suzanne G. Mays, Autumn R. Flynn, Guohui Wang, John W. Calvert, C. Denise Okafor, Jeffery L. Cornelison, Dianna Melchers, David D. Moore, Xu Liu, Eric A. Ortlund, Elizabeth J. Millings, Nathan T. Jui, Anamika Patel, René Houtman, Xiangsheng Huang, Michael L. Cato, Emma H. D’Agostino
Phospholipids are ligands for nuclear hormone receptors (NRs) and regulate transcriptional programs relevant to normal physiology and disease. Here, we demonstrate that mimicking phospholipid-NR interactions greatly improves agonists of liver recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42cc9126f194e90a3a5b125221c1c134
https://doi.org/10.1101/2020.09.01.278291
https://doi.org/10.1101/2020.09.01.278291
Autor:
R. Polavarapu, Autumn R. Flynn, Elizabeth J. Millings, Suzanne G. Mays, Eric A. Ortlund, Haichao Wang, Guohui Wang, David D. Moore, John W. Calvert, Nathan T. Jui, H. N. Donaldson, J. L. Corneilson, Xiangsheng Huang, C. D. Okafor
Publikováno v:
Journal of medicinal chemistry, vol 62, iss 24
J Med Chem
J Med Chem
As a key regulator of metabolism and inflammation, the orphan nuclear hormone receptor, Liver Receptor Homolog-1 (LRH-1), has potential as a therapeutic target for diabetes, nonalcoholic fatty liver disease, and inflammatory bowel diseases. Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec68b5695fef193365fa1212c369967
https://escholarship.org/uc/item/6ns455v5
https://escholarship.org/uc/item/6ns455v5
Autor:
Charles A. LeDuc, Rudolph Leibel, Kazuhisa Watanabe, Sadahiko Iwamoto, Ken Yoshida, Elizabeth J. Millings, Kazuhiro Nakayama
Publikováno v:
Diabetes. 67
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity and type 2 diabetes, and increases the risk for liver cirrhosis and cancer. A diabetes susceptibility gene, ILDR2, encodes a transmembrane protein localized to the ER membrane whose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b6ed1aff51558b10d78f2b627fc3d92
https://doi.org/10.2337/db18-1994-p
https://doi.org/10.2337/db18-1994-p
Publikováno v:
Synthetic Communications. 43:1902-1908
Synthesis of five membered heterocycles from an aryl tribromomethyl functional group is discussed. Exposing a tribromomethyl group to subsequent nucleophilic attacks by a 1,2-di-nucleophilic species promotes the cyclization of five membered heterocyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::594bf273668b0459219517b73772bf7d
https://doi.org/10.1080/00397911.2012.679331
https://doi.org/10.1080/00397911.2012.679331
Autor:
Charles A. LeDuc, Sadahiko Iwamoto, Supichaya Boonvisut, Elizabeth J. Millings, Stuart G. Fischer, Kazuhiro Nakayama, Kazuhisa Watanabe, Satoshi Ohta, Rudolph L. Leibel, Kenji Tago
Publikováno v:
Biochemical and biophysical research communications. 477(4)
A diabetes susceptibility gene, immunoglobulin-like domain containing receptor 2 (Ildr2), encodes a transmembrane protein localized to the endoplasmic reticulum membrane that is closely related to hepatic lipid metabolism. The livers of ob/ob mice in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6620bd9c127457a0da585a8552c323
https://pubmed.ncbi.nlm.nih.gov/27353377
https://pubmed.ncbi.nlm.nih.gov/27353377
Autor:
Rudolph L. Leibel, Kazuhisa Watanabe, Richard Rausch, Charles A. LeDuc, Sarah E. Fleet, Maria Caterina De Rosa, Gen Li, Stuart G. Fischer, Elizabeth J. Millings, Yiying Zhang, Dieter Egli
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197548 (2018)
PLoS ONE
PLoS ONE
We have previously reported that Ildr2 knockdown via adenovirally-delivered shRNA causes hepatic steatosis in mice. In the present study we investigated hepatic biochemical and anatomic phenotypes of Cre-mediated Ildr2 knock-out mice. Liver-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0618950722ffa116292069551f3b3073
https://doi.org/10.1371/journal.pone.0197548
https://doi.org/10.1371/journal.pone.0197548
Publikováno v:
ChemInform. 44
Synthesis of five membered heterocycles from an aryl tribromomethyl functional group is discussed. Exposing a tribromomethyl group to subsequent nucleophilic attacks by a 1,2-di-nucleophilic species promotes the cyclization of five membered heterocyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f43f3692c9685f44648bcaeb31e899d9
https://doi.org/10.1002/chin.201340031
https://doi.org/10.1002/chin.201340031