Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elizabeth J. Manos"'
Autor:
Xiaomei Wei, Tim S. Bugni, Mary Kay Harper, Imelda T. Sandoval, Elizabeth J. Manos, Jennifer Swift, Ryan M. Van Wagoner, David A. Jones, Chris M. Ireland
Publikováno v:
Marine Drugs, Vol 8, Iss 6, Pp 1769-1778 (2010)
Three new minor components, the pyridoacridine alkaloids 1-hydroxy-deoxyamphimedine (1), 3-hydroxy-deoxyamphimedine (2), debromopetrosamine (3), and three known compounds, amphimedine (4), neoamphimedine (5) and deoxyamphimedine (6), have been isolat
Externí odkaz:
https://doaj.org/article/6da992cc4e684453bf5ea1b3b8317a76
Autor:
Ryan M. Van Wagoner, Imelda T. Sandoval, Xiaomei Wei, David A. Jones, Elizabeth J. Manos, Mary Kay Harper, Jennifer Swift, Chris M. Ireland, Tim S. Bugni
Publikováno v:
Marine Drugs, Vol 8, Iss 6, Pp 1769-1778 (2010)
Marine Drugs
Volume 8
Issue 6
Pages 1769-1778
Marine Drugs
Volume 8
Issue 6
Pages 1769-1778
Three new minor components, the pyridoacridine alkaloids 1-hydroxy-deoxyamphimedine (1), 3-hydroxy-deoxyamphimedine (2), debromopetrosamine (3), and three known compounds, amphimedine (4), neoamphimedine (5) and deoxyamphimedine (6), have been isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017f670a8c196b27973c564b822338ec
http://www.mdpi.com/1660-3397/8/6/1769/
http://www.mdpi.com/1660-3397/8/6/1769/
Autor:
Kunal Rai, Smitha R. James, David A. Jones, Bradley R. Cairns, Adam R. Karpf, Elizabeth J. Manos, Stephanie Chidester, Lincoln Nadauld
Publikováno v:
Molecular and Cellular Biology. 26:7077-7085
DNA methylation and histone methylation are two key epigenetic modifications that help govern heterochromatin dynamics. The roles for these chromatin-modifying activities in directing tissue-specific development remain largely unknown. To address thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c119a75a9d1022611165997eed4b73
https://doi.org/10.1128/mcb.00312-06
https://doi.org/10.1128/mcb.00312-06
Autor:
Chris M. Ireland, Eryn Hadley, David A. Jones, Peter Peterson, Elizabeth J. Manos, Cicely A. Jette, Imelda T. Sandoval
Publikováno v:
Journal of Biological Chemistry. 279:34397-34405
Development of normal colon epithelial cells proceeds through a systematic differentiation of cells that emerge from stem cells within the base of colon crypts. Genetic mutations in the adenomatous polyposis coli (APC) gene are thought to cause colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7768f8d53273ecf546135fba97520eda
https://doi.org/10.1074/jbc.m314021200
https://doi.org/10.1074/jbc.m314021200
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 284:L663-L670
Neutrophils respond to infection by degranulation, release of reactive oxygen intermediates, and secretion of chemokines and cytokines; however, activation of neutrophil transcriptional machinery has been little appreciated. Recent findings suggest t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5106c7d6faf0e5643c14c192a90c95
https://doi.org/10.1152/ajplung.00094.2002
https://doi.org/10.1152/ajplung.00094.2002
Autor:
David A. Jones, Marianne L H Kim, Elizabeth J. Manos, Alan Wells, Pei Yun Chang, Jareer Kassis
Publikováno v:
Oncogene. 20:2781-2790
The most ominous development in tumor progression is the transition to an invasive and metastatic phenotype. Little is known, however, about the molecular alterations that cause a tumor to become invasive. In view of this, we have used microarray exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fda36ce131d62c12d29e755fcd87bb
https://doi.org/10.1038/sj.onc.1204379
https://doi.org/10.1038/sj.onc.1204379
Autor:
Peggy Scherle, Ronald L. Magolda, Phillip M. Czerniak, Robert Collins, James M. Trzaskos, Margaret F. Favata, Elizabeth J. Manos, Bruce D. Jaffee
Publikováno v:
Biochemical and Biophysical Research Communications. 268:647-651
The MAP kinase pathway has been well-characterized as a cascade of sequential protein phosphorylation events leading to the upregulation of a variety of genes in response to growth factors and mitogens. We are interested in the role of these kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9212c0936daa9c80fa5e9af241e9cae
https://doi.org/10.1006/bbrc.2000.2184
https://doi.org/10.1006/bbrc.2000.2184
Autor:
Santella Joseph B, John Wityak, Ruth R. Wexler, Robert A. Copeland, Pitts William J, Deborah A. Stradley, Frank W. Hobbs, Peggy Scherle, Elizabeth J. Manos, A. Christine Tabaka, Jung-Hui Sun, Kurumi Y. Horiuchi, James M. Trzaskos, William Eric Frietze, Ronald L. Magolda, Duncia John, Andrea J. Daulerio, Richard E. Olson, C. Anne Higley, Christopher A. Teleha, Richard A. Earl, F.Wayne Rankin, Margaret F. Favata, Karl F. Blom, George L. Trainor
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2839-2844
In search of antiinflammatory drugs with a new mechanism of action, U0126 was found to functionally antagonize AP-1 transcriptional activity via noncompetitive inhibition of the dual specificity kinase MEK with an IC50 of 0.07 microM for MEK 1 and 0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e7239bbbcdbe88ce04a2dcd87efb1e
https://doi.org/10.1016/s0960-894x(98)00522-8
https://doi.org/10.1016/s0960-894x(98)00522-8
Autor:
Drew E. Van Dyk, Margaret F. Favata, Ronald L. Magolda, Kurumi Y. Horiuchi, Elizabeth J. Manos, Frank W. Hobbs, James M. Trzaskos, Wendi S. Feeser, Andrea J. Daulerio, Peggy Scherle, Pitts William J, Deborah A. Stradley, Robert A. Copeland, Richard A. Earl
Publikováno v:
Journal of Biological Chemistry. 273:18623-18632
The compound U0126 (1,4-diamino-2,3-dicyano-1, 4-bis[2-aminophenylthio]butadiene) was identified as an inhibitor of AP-1 transactivation in a cell-based reporter assay. U0126 was also shown to inhibit endogenous promoters containing AP-1 response ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c78493f6f4c58d71f359d734366520
https://doi.org/10.1074/jbc.273.29.18623
https://doi.org/10.1074/jbc.273.29.18623
Publikováno v:
Cellular Immunology. 180:116-123
Stimulation of T cells through the TCR leads to activation of the mitogen-activated protein kinase (MAPK) family members ERK (extracellular signal-regulated kinase) and JNK (jun NH2-terminal kinase). These kinases act in synergy to increase the activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371f875221a87c3cf8b65e74b72f9fd5
https://doi.org/10.1006/cimm.1997.1182
https://doi.org/10.1006/cimm.1997.1182