Výsledky vyhledávání - "Elizabeth J. Hudson"

VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells

Autor: Lisa C. Jones, Wanda K. O'Neal, Yunxiang Zhu, Eduardo R. Lazarowski, Richard C. Boucher, Lama Moussa, Silvia M. Kreda, M. Leslie Fulcher, Scott H. Randell, Elizabeth J. Hudson

Publikováno v: The Journal of Physiology. 590:545-562

Mucin secretion is an innate defence mechanism, which is noxiously upregulated in obstructive lung diseases (e.g. chronic obstructive pulmonary disease (COPD), cystic fibrosis and asthma). Mucin granule exocytosis is regulated by specific protein com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2deacdf25dd6cc719f93cdcb991af248
https://doi.org/10.1113/jphysiol.2011.222091

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Airway and Lung Pathology Due to Mucosal Surface Dehydration in β-Epithelial Na+ Channel-Overexpressing Mice: Role of TNF-α and IL-4Rα Signaling, Influence of Neonatal Development, and Limited Efficacy of Glucocorticoid Treatment

Autor: Kristen J. Wilkinson, Elizabeth J. Hudson, Richard C. Boucher, Scott H. Randell, Alessandra Livraghi, John K. Sheehan, Wanda K. O'Neal, Barbara R. Grubb, Marcus A. Mall

Publikováno v: The Journal of Immunology. 182:4357-4367

Overexpression of the epithelial Na+ channel β subunit (Scnn1b gene, βENaC protein) in transgenic (Tg) mouse airways dehydrates mucosal surfaces, producing mucus obstruction, inflammation, and neonatal mortality. Airway inflammation includes macrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420fc2c9ac5cc08a78aa046f54a0cf9c
https://doi.org/10.4049/jimmunol.0802557

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Development of Chronic Bronchitis and Emphysema in β-Epithelial Na+ Channel–Overexpressing Mice

Autor: Alessandra Livraghi, Elizabeth J. Hudson, Richard C. Boucher, Joanna B. Trojanek, Diana Treis, Silvia M. Kreda, Marcus A. Mall, Wanda K. O'Neal, Zhe Zhou, Susanne C. Schubert, Stephen L. Tilley, Jack R. Harkema

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 177:730-742

Rationale: Chronic obstructive pulmonary disease is a leading cause of death worldwide, but its pathogenesis is not well understood. Previous studies have shown that airway surface dehydration in β-epithelial Na+ channel (βENaC)–overexpressing mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3906c60f20bc11102bb20af9a26068d
https://doi.org/10.1164/rccm.200708-1233oc

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