Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Elizabeth J. Herman"'
Autor:
Jason Manka, Hilde Lavreysen, Colleen M. Niswender, Jon Jacobs, M. Luz Martín-Martín, P. Jeffrey Conn, Meredith J. Noetzel, Han Min Tong, Elizabeth J. Herman, C. David Weaver, Chrysa Malosh, J. Scott Daniels, Susana Conde-Ceide, Paige N. Vinson, Shaun R. Stauffer, Gregor James Macdonald, Claire Mackie, José Manuel Bartolomé-Nebreda, Thomas Steckler, Silvia López, Craig W. Lindsley, Carrie K. Jones, Satyawan Jadhav, Mark Turlington
Publikováno v:
Journal of Medicinal Chemistry. 57:5620-5637
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec9e09891e97fb3e6b29c5a56f045fdf
https://doi.org/10.1021/jm500259z
https://doi.org/10.1021/jm500259z
Autor:
Jason Manka, Thomas Steckler, Ya Zhou, Hilde Lavreysen, José M. Bartolomé, Elizabeth J. Herman, Karen J. Gregory, Colleen M. Niswender, Carrie K. Jones, Claire Mackie, P. Jeffrey Conn, Satya Jadhav, Kiran Gogi, Paige N. Vinson, C. David Weaver, Gregor James Macdonald, Emily Days, Shaun R. Stauffer, Richard Williams, J. Scott Daniels, Craig W. Lindsley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6481-6485
We report the optimization of a series of non-MPEP site metabotropic glutamate receptor 5 (mGlu(5)) positive allosteric modulators (PAMs) based on a simple acyclic ether series. Modifications led to a gain of MPEP site interaction through incorporati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d534ec9be8ddffac91a13e546689a725
https://doi.org/10.1016/j.bmcl.2012.08.043
https://doi.org/10.1016/j.bmcl.2012.08.043
Autor:
Gema G. Dumitru, Elizabeth J. Herman, Kristine A. Valenzuela, Magdala Peixoto Labre, Christy L. Cechman
Publikováno v:
American Journal of Preventive Medicine. 42:403-410
Context Asthma is a chronic respiratory disease increasingly prevalent in the U.S., particularly among children and certain minority groups. This umbrella review sought to assess and summarize existing systematic reviews of asthma-related interventio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f6c2722e8dedb3ed6e5ff4dca2e403
https://doi.org/10.1016/j.amepre.2011.11.016
https://doi.org/10.1016/j.amepre.2011.11.016
Autor:
Deidre D. Crocker, Stella Kinyota, Gema G. Dumitru, Colin B. Ligon, Elizabeth J. Herman, Jill M. Ferdinands, David P. Hopkins, Briana M. Lawrence, Theresa A. Sipe
Publikováno v:
American Journal of Preventive Medicine. 41:S5-S32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b630d58d2c806cfc5f284459efd7eecd
https://doi.org/10.1016/j.amepre.2011.05.012
https://doi.org/10.1016/j.amepre.2011.05.012
Autor:
Stella Kinyota, Briana Lawrence, Jill M. Ferdinands, Elizabeth J. Herman, Theresa Ann Sipe, Colin B. Ligon, David S. P. Hopkins, Deidre D. Crocker, Gema G. Dumitru
Publikováno v:
American Journal of Preventive Medicine. 41:S33-S47
Context: Asthma exacerbations are commonly triggered by exposure to allergens and irritants within the home. The purpose of this review was to evaluate evidence that interventions that target reducing these triggers through home visits may be benefic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76c936f71e3527c206e8ca1d409cfe00
https://doi.org/10.1016/j.amepre.2011.05.011
https://doi.org/10.1016/j.amepre.2011.05.011
Autor:
Mark, Turlington, Chrysa, Malosh, Jon, Jacobs, Jason T, Manka, Meredith J, Noetzel, Paige N, Vinson, Satyawan, Jadhav, Elizabeth J, Herman, Hilde, Lavreysen, Claire, Mackie, José M, Bartolomé-Nebreda, Susana, Conde-Ceide, M Luz, Martín-Martín, Han Min, Tong, Silvia, López, Gregor J, MacDonald, Thomas, Steckler, J Scott, Daniels, C David, Weaver, Colleen M, Niswender, Carrie K, Jones, P Jeffrey, Conn, Craig W, Lindsley, Shaun R, Stauffer
Publikováno v:
Journal of Medicinal Chemistry
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4df281b61dd2aa143b71583ecf87d1c8
https://pubmed.ncbi.nlm.nih.gov/24914612
https://pubmed.ncbi.nlm.nih.gov/24914612
Publikováno v:
Novel Antischizophrenia Treatments ISBN: 9783642257575
Metabotropic glutamate receptors (mGluRs) represent exciting targets for the development of novel therapeutic agents for schizophrenia. Recent studies indicate that selective activation of specific mGluR subtypes may provide potential benefits for no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cfc8b03f294f9a27257edfabcadebb6
https://doi.org/10.1007/978-3-642-25758-2_11
https://doi.org/10.1007/978-3-642-25758-2_11
Autor:
Magdala P, Labre, Elizabeth J, Herman, Gema G, Dumitru, Kristine A, Valenzuela, Christy L, Cechman
Publikováno v:
American journal of preventive medicine. 42(4)
Asthma is a chronic respiratory disease increasingly prevalent in the U.S., particularly among children and certain minority groups. This umbrella review sought to assess and summarize existing systematic reviews of asthma-related interventions that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b2d6121ed9ec14752f343ad857e6121
https://pubmed.ncbi.nlm.nih.gov/22424254
https://pubmed.ncbi.nlm.nih.gov/22424254
Autor:
James Chapman, Kristy Bouchard, Alvin V. Terry, Jie Gao, Jerry J. Buccafusco, Patrick M. Callahan, Gary M. Schwarz, Elizabeth J. Herman, Samantha E. Warner, Wayne D. Beck, Leah Vandenhuerk
This study was designed to evaluate further a prototypical ranitidine analog, JWS-USC-75-IX, [(3-[[[2-[[(5-dimethylaminomethyl)-2-furanyl]methyl]thio]ethyl]amino]-4-nitropyridazine, JWS], for neuropharmacologic properties that would theoretically be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94c3c5213da0fd26865582d6e483931
https://europepmc.org/articles/PMC3061527/
https://europepmc.org/articles/PMC3061527/
Autor:
Deidre D, Crocker, Stella, Kinyota, Gema G, Dumitru, Colin B, Ligon, Elizabeth J, Herman, Jill M, Ferdinands, David P, Hopkins, Briana M, Lawrence, Theresa A, Sipe
Publikováno v:
American journal of preventive medicine. 41(2 Suppl 1)
Asthma exacerbations are commonly triggered by exposure to allergens and irritants within the home. The purpose of this review was to evaluate evidence that interventions that target reducing these triggers through home visits may be beneficial in im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::903555cfc71d8a2ad52e70b6a09a3267
https://pubmed.ncbi.nlm.nih.gov/21767739
https://pubmed.ncbi.nlm.nih.gov/21767739