Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Elizabeth J. Bradbury"'
Autor:
Ieva Berzanskyte, Federica Riccio, Carolina Barcellos Machado, Elizabeth J. Bradbury, Ivo Lieberam
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract V3 spinal interneurons are a key element of the spinal circuits, which control motor function. However, to date, there are no effective ways of deriving a pure V3 population from human pluripotent stem cells. Here, we report a method for dif
Externí odkaz:
https://doaj.org/article/4876deb6c3b94c34a4b33ce9189c5205
Autor:
Isaac Francos-Quijorna, Marina Sánchez-Petidier, Emily R. Burnside, Smaranda R. Badea, Abel Torres-Espin, Lucy Marshall, Fred de Winter, Joost Verhaagen, Victoria Moreno-Manzano, Elizabeth J. Bradbury
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Inflammation resolution failure is a pathological hallmark of spinal cord injury. Here, the authors show in rodents that chondroitin sulfate proteoglycans contribute to failed resolution by preventing immune cells at the injury core from converting t
Externí odkaz:
https://doaj.org/article/1fa069c153554f5aa4e6bb33426afeed
Autor:
Benjamin Jevans, Nicholas D. James, Emily Burnside, Conor J. McCann, Nikhil Thapar, Elizabeth J. Bradbury, Alan J. Burns
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Abstract Background Spinal cord injury (SCI) presents a significant challenge for the field of neurotherapeutics. Stem cells have shown promise in replenishing the cells lost to the injury process, but the release of axon growth-inhibitory molecules
Externí odkaz:
https://doaj.org/article/3fd43e2b9dbd474895f89c16bfd7d6c7
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The scar formation that occurs following spinal cord injury has properties that are distinct to scars seen in other areas of the CNS, and in other tissues. Here the authors discuss the components of the spinal cord injury scar and how it can have bot
Externí odkaz:
https://doaj.org/article/7329e328d4eb4c72988d9c30c01e76e3
Autor:
Emad Moeendarbary, Isabell P. Weber, Graham K. Sheridan, David E. Koser, Sara Soleman, Barbara Haenzi, Elizabeth J. Bradbury, James Fawcett, Kristian Franze
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Glial scars are thought to provide a biochemical and mechanical barrier to neuronal regeneration post-injury, but the mechanical properties of the scars have not been studied in detail. Here the authors perform atomic force microscopy measurements of
Externí odkaz:
https://doaj.org/article/f3d2bdc08870472282335918d0b3b16c
Autor:
Nicholas D. James, Maria Angéria, Elizabeth J. Bradbury, Peter Damberg, Stephen B. McMahon, Mårten Risling, Thomas Carlstedt
Publikováno v:
Frontiers in Neurology, Vol 8 (2017)
In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to
Externí odkaz:
https://doaj.org/article/65a059fe662e465d9cb2cf73e8ff20dc
Autor:
Eleni Sinopoulou, Aline Barroso Spejo, Naomi Roopnarine, Emily R. Burnside, Katalin Bartus, Fred De Winter, Stephen B. McMahon, Elizabeth J. Bradbury
Publikováno v:
Journal of Neuroscience Research, 100, 2055-2076. Wiley-Liss Inc.
Cervical level spinal cord injury (SCI) can severely impact upper limb muscle function, which is typically assessed in the clinic using electromyography (EMG). Here, we established novel preclinical methodology for EMG assessments of muscle function
Publikováno v:
Pain. 163(3)
Autor:
Nicholas D. James, Nikhil Thapar, Alan J. Burns, Elizabeth J. Bradbury, Benjamin Jevans, Conor J. McCann, Emily R. Burnside
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Stem cell research & therapy 12(1), 10 (2021). doi:10.1186/s13287-020-02031-9
Stem Cell Research and Therapy, 12(1):10. BioMed Central Ltd.
Stem Cell Research & Therapy
Stem cell research & therapy 12(1), 10 (2021). doi:10.1186/s13287-020-02031-9
Stem Cell Research and Therapy, 12(1):10. BioMed Central Ltd.
Stem Cell Research & Therapy
Background Spinal cord injury (SCI) presents a significant challenge for the field of neurotherapeutics. Stem cells have shown promise in replenishing the cells lost to the injury process, but the release of axon growth-inhibitory molecules such as c
Autor:
Elizabeth J. Bradbury, Raquel Oliveira
Publikováno v:
Brain
After CNS trauma such as spinal cord injury, the ability of surviving neural elements to sprout axons, reorganize neural networks and support recovery of function is severely restricted, contributing to chronic neurological deficits. Among limitation