Výsledky vyhledávání - "Elizabeth J. Blaney"

Correlation of LUMO localization with the α-amylase inhibition constant in a Tendamistat-based series of linear and cyclic peptides

Autor: Steve Fernandes, Deborah L. Heyl, Jennifer Stephens, Jana Jacobs, Dennis Brown, Todd Pasko, Leena Khullar, Horacia Opang-Owusu, M.C. Milletti, Danielle Bailey, Elizabeth J. Blaney, Benjamin Stahelin

Publikováno v: Bioorganic & Medicinal Chemistry. 13:4262-4268

The glycosidase alpha-amylase is responsible for the hydrolysis of alpha(1--4) glycosidic linkages found in dietary starch as one means for controlling blood sugar level. The effect of alpha-amylase is detrimental, however, in the disease state diabe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fa62349b6d3cf5142dd6ebfb5ab957
https://doi.org/10.1016/j.bmc.2005.04.019

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Peptide Inhibitors of a-Amylase Based on Tendamistat: Development of Analogues with ϖ-Amino Acids Linking Critical Binding Segments

Autor: Stephen E. Schullery, Shakila Tobwala, Deborah L. Heyl, Rebecca W. Himm, A. Dammika Nandanie, Jeffrey Asbill, Jonathan K. Nzoma, Leo Solomon Lucas, Jennifer Kappler, Cara Jarosz, Hanna Palamma, Jason Groom, Elizabeth J. Blaney

Publikováno v: Protein & Peptide Letters. 12:275-280

Peptide analogues of Tendamistat which include the most essential residues linked by novel w-amino acids (X,Y,Z: H2N-(CH2)n-CO2H, where n=2-10) were designed, synthesized (Ac-Tyr15-X-Trp18-Arg19-Tyr20-Y-Thr55-Z-Asp58- Gly59-Tyr60-Ile61-Gly62-NH2), an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08a81bf5befeb2ea364f17627420dd14
https://doi.org/10.2174/0929866053587110

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Peptide inhibitors of alpha-amylase based on tendamistat: development of analogues with omega-amino acids linking critical binding segments

Autor: Deborah L, Heyl, Shakila, Tobwala, Leo Solomon, Lucas, A Dammika, Nandanie, Rebecca W, Himm, Himm Jennifer, Kappler, Elizabeth J, Blaney, Jason, Groom, Jeffrey, Asbill, Jonathan K, Nzoma, Cara, Jarosz, Hanna, Palamma, Stephen E, Schullery

Publikováno v: Protein and peptide letters. 12(3)

Peptide analogues of Tendamistat which include the most essential residues linked by novel omega-amino acids (X,Y,Z: H2N-(CH2)n-CO(2)H, where n=2-10) were designed, synthesized (Ac-Tyr(15)-X-Trp(18)-Arg(19)-Tyr(20)-Y-Thr(55)-Z-Asp(58)-Gly(59)-Tyr(60)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::874268faf58f76d7853809db01acef58
https://pubmed.ncbi.nlm.nih.gov/15777278

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