Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Elizabeth J Osterlund"'
Autor:
James M Pemberton, Dang Nguyen, Elizabeth J Osterlund, Wiebke Schormann, Justin P Pogmore, Nehad Hirmiz, Brian Leber, David W Andrews
Publikováno v:
eLife, Vol 12 (2023)
Anti-apoptotic proteins such as BCL-XL promote cell survival by sequestering pro-apoptotic BCL-2 family members, an activity that frequently contributes to tumorigenesis. Thus, the development of small-molecule inhibitors for anti-apoptotic proteins,
Externí odkaz:
https://doaj.org/article/c46858294f8f416e96855c98bce4cf03
Autor:
Xiaoke Chi, Dang Nguyen, James M Pemberton, Elizabeth J Osterlund, Qian Liu, Hetal Brahmbhatt, Zhi Zhang, Jialing Lin, Brian Leber, David W Andrews
Publikováno v:
eLife, Vol 9 (2020)
The Bcl-2 family BH3 protein Bim promotes apoptosis at mitochondria by activating the pore-forming proteins Bax and Bak and by inhibiting the anti-apoptotic proteins Bcl-XL, Bcl-2 and Mcl-1. Bim binds to these proteins via its BH3 domain and to the m
Externí odkaz:
https://doaj.org/article/3930186c3fd04ad4a33907088e2464c2
Autor:
Qian Liu, Elizabeth J Osterlund, Xiaoke Chi, Justin Pogmore, Brian Leber, David William Andrews
Publikováno v:
eLife, Vol 8 (2019)
Tumor initiation, progression and resistance to chemotherapy rely on cancer cells bypassing programmed cell death by apoptosis. We report that unlike other pro-apoptotic proteins, Bim contains two distinct binding sites for the anti-apoptotic protein
Externí odkaz:
https://doaj.org/article/35be500a47c444d396b9241785a6b15f
Autor:
Nehad Hirmiz, Elizabeth J Osterlund, Morgan Richards, David W. Andrews, Qiyin Fang, Anthony Tsikouras
Publikováno v:
IEEE Journal of Selected Topics in Quantum Electronics. 27:1-9
Protein-protein interactions can be measured in live cells, at nanometer scale, using Fluorescence Lifetime Imaging Microscopy (FLIM) enabled Forster Resonance Energy Transfer (FRET). There are growing interests in exploring protein-protein interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173a48143a9029e3ea1ef2ef0559be55
https://doi.org/10.1109/jstqe.2020.2997834
https://doi.org/10.1109/jstqe.2020.2997834
Fluorescence lifetime imaging microscopy (FLIM) can detect Fӧrster resonance energy transfer (FRET) to measure protein-protein interactions in live cells. Traditional FLIM-FRET uses relative intensities to represent protein expression, consequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3882eb55242b985bb0f537024ad6625c
https://doi.org/10.21203/rs.3.pex-1354/v1
https://doi.org/10.21203/rs.3.pex-1354/v1
Autor:
Elizabeth J. Osterlund, Nehad Hirmiz, James M. Pemberton, Adrien Nougarède, Qian Liu, Brian Leber, Qiyin Fang, David W. Andrews
Publikováno v:
Science Advances. 8
Cytoplasmic and membrane-bound BCL-2 family proteins regulate apoptosis, a form of programmed cell death, via dozens of binary protein interactions confounding measurement of the effects of inhibitors in live cells. In cancer, apoptosis is frequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7693edb79c1d1712aef49cd51ea6871a
https://doi.org/10.1126/sciadv.abm7375
https://doi.org/10.1126/sciadv.abm7375
Autor:
Elizabeth J. Osterlund, Nehad Hirmiz, Dang Nguyen, James M. Pemberton, Qiyin Fang, David W. Andrews
Publikováno v:
Journal of Biological Chemistry. 299:102863
The pro-apoptotic BH3-only endoplasmic reticulum (ER) resident protein BIK, positively regulates mitochondrial outer membrane permeabilization (MOMP), the point-of-no-return in apoptosis. It is generally accepted that BIK functions at a distance from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8c1ad2b2eaba6938b9f3607b4d6555
https://doi.org/10.1016/j.jbc.2022.102863
https://doi.org/10.1016/j.jbc.2022.102863
Autor:
David W. Andrews, Jialing Lin, Qian Liu, Dang Nguyen, Xiaoke Chi, Hetal Brahmbhatt, James M. Pemberton, Brian Leber, Zhi Zhang, Elizabeth J Osterlund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e5d9195bdd01553fa821926258cef26
https://doi.org/10.7554/elife.44525.sa2
https://doi.org/10.7554/elife.44525.sa2
Publikováno v:
Cell Death and Differentiation
The BCL-2 family of proteins controls cell death primarily by direct binding interactions that regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible release of intermembrane space proteins, subsequent caspase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47030f67ac553cd20233529f236c4fe3
https://doi.org/10.1038/cdd.2017.186
https://doi.org/10.1038/cdd.2017.186