Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Elizabeth J Grayhack"'
Publikováno v:
eLife, Vol 7 (2018)
Reading frame maintenance is critical for accurate translation. We show that the conserved eukaryotic/archaeal protein Mbf1 acts with ribosomal proteins Rps3/uS3 and eukaryotic Asc1/RACK1 to prevent frameshifting at inhibitory CGA-CGA codon pairs in
Externí odkaz:
https://doaj.org/article/98d6b72363e841d2ac7231460cdbc6a9
Ribosome stalls can result in ribosome collisions that elicit quality control responses, one function of which is to prevent frameshifting by the stalled ribosome, an activity that entails interaction of the conserved yeast protein Mbf1 with uS3 on c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12023cbe58929572e031cf0ead21cb15
https://doi.org/10.1101/2021.08.26.457827
https://doi.org/10.1101/2021.08.26.457827
Publikováno v:
Nucleic Acids Research
Synonymous codons provide redundancy in the genetic code that influences translation rates in many organisms, in which overall codon use is driven by selection for optimal codons. It is unresolved if or to what extent translational selection drives u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::880de400a9a234ed96346eec0c030b13
http://europepmc.org/articles/PMC6379720
http://europepmc.org/articles/PMC6379720
Autor:
Jesse P. Frumkin, Arend Hintze, Eric M. Phizicky, Bruz Marzolf, Alpan Raval, Biranchi N. Patra, Nitin S. Baliga, Amardeep Kaur, Elizabeth J. Grayhack, Ashish Bhan, Jenna K. Tamashiro, David J. Galas, Anthony W. Sevold, Christoph Adami, Ravishankar R. Vallabhajosyula, Gitanjali Yadav, Bjørn Østman, Jory Schossau, Yoshiko Kon, Animesh Ray
Publikováno v:
Nucleic Acids Research
Genomic robustness is the extent to which an organism has evolved to withstand the effects of deleterious mutations. We explored the extent of genomic robustness in budding yeast by genome wide dosage suppressor analysis of 53 conditional lethal muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cba98019227571b841fcbccb28be4b
http://europepmc.org/articles/PMC5224485
http://europepmc.org/articles/PMC5224485
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Reading frame maintenance is critical for accurate translation. We show that the conserved eukaryotic/archaeal protein Mbf1 acts with ribosomal proteins Rps3/uS3 and eukaryotic Asc1/RACK1 to prevent frameshifting at inhibitory CGA-CGA codon pairs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6bc410987611d92780a9db0dc2bb6a
https://doi.org/10.1101/366344
https://doi.org/10.1101/366344
Autor:
Jeremiah D. Baldeck, Pedro Luiz Rosalen, Brendaliz Santiago, Cory J. Hubbard, Kathy Scott-Anne, Robert G. Quivey, James E. Payne, Elizabeth J. Grayhack, Shuba Gopal, Andrew S. Wolf, Robert E. Marquis, Matthew E. MacGilvray, Roberta C. Faustoferri
Publikováno v:
Molecular Oral Microbiology. 30:474-495
A collection of tagged deletion mutant strains was created in Streptococcus mutans UA159 to facilitate investigation of the aciduric capability of this oral pathogen. Gene-specific barcoded deletions were attempted in 1432 open reading frames (repres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd847a8e41452a911bb9a4be04360da
https://doi.org/10.1111/omi.12107
https://doi.org/10.1111/omi.12107
The genetic code, which defines the amino acid sequence of a protein, also contains information that influences the rate and efficiency of translation. Neither the mechanisms nor functions of codon-mediated regulation were well understood. The prevai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f6e1194ff00d6b4622ab14cb953c57
https://europepmc.org/articles/PMC5409834/
https://europepmc.org/articles/PMC5409834/
Autor:
David L. Young, Matthew J. Payea, Eric M. Phizicky, David H. Mathews, Xiaoju Zhang, Yoshiko Kon, Stanley Fields, Elizabeth J. Grayhack, Kimberly Dean, Michael P. Guy
Publikováno v:
Genes & Development. 28:1721-1732
Sequence variation in tRNA genes influences the structure, modification, and stability of tRNA; affects translation fidelity; impacts the activity of numerous isodecoders in metazoans; and leads to human diseases. To comprehensively define the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b90775e30de3c205cbdecac6be86ba4
https://doi.org/10.1101/gad.245936.114
https://doi.org/10.1101/gad.245936.114
Autor:
Jeff Coller, Elizabeth J. Grayhack
Publikováno v:
Methods. 137:1-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81873b8aa0cb5298d0701abe55fa6ec
https://doi.org/10.1016/j.ymeth.2018.03.005
https://doi.org/10.1016/j.ymeth.2018.03.005