Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elizabeth J Fay"'
Autor:
Brian V Tsu, Rimjhim Agarwal, Nandan S Gokhale, Jessie Kulsuptrakul, Andrew P Ryan, Elizabeth J Fay, Lennice K Castro, Christopher Beierschmitt, Christina Yap, Elizabeth A Turcotte, Sofia E Delgado-Rodriguez, Russell E Vance, Jennifer L Hyde, Ram Savan, Patrick S Mitchell, Matthew D Daugherty
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002144 (2023)
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CLpro) encoded by diverse c
Externí odkaz:
https://doaj.org/article/cdf5043f3dfb4817b3329b51ef3b0db4
Autor:
Elizabeth J Fay, Stephanie L Aron, Marissa G Macchietto, Matthew W Markman, Katharina Esser-Nobis, Michael Gale, Steven Shen, Ryan A Langlois
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008760 (2020)
Influenza A viruses (IAVs) remain a significant global health burden. Activation of the innate immune response is important for controlling early virus replication and spread. It is unclear how early IAV replication events contribute to immune detect
Externí odkaz:
https://doaj.org/article/ffad707fe5244c40bea9cea2394e64c5
Autor:
Janice M. Reimer, Andrea M. Dickey, Yu Xuan Lin, Robert G. Abrisch, Sebastian Mathea, Deep Chatterjee, Elizabeth J. Fay, Stefan Knapp, Matthew D. Daugherty, Samara L. Reck-Peterson, Andres E. Leschziner
Leucine Rich Repeat Kinase 1 and 2 (LRRK1 and LRRK2) are homologs in the ROCO family of proteins in humans. Despite their shared domain architecture and involvement in intracellular trafficking, their disease associations are strikingly different: LR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc87af7022e01bc85212e35409e1f071
https://doi.org/10.1101/2022.11.22.517582
https://doi.org/10.1101/2022.11.22.517582
Autor:
Brian V. Tsu, Rimjhim Agarwal, Nandan S. Gokhale, Jessie Kulsuptrakul, Andrew P. Ryan, Lennice K. Castro, Christopher M. Beierschmitt, Elizabeth A. Turcotte, Elizabeth J. Fay, Russell E. Vance, Jennifer L. Hyde, Ram Savan, Patrick S. Mitchell, Matthew D. Daugherty
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CLpro) encoded by diverse c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60961e6666e00b8cd2dfdf2b6cf1f3f9
https://doi.org/10.1101/2022.09.21.508960
https://doi.org/10.1101/2022.09.21.508960
Autor:
Elizabeth J. Fay, Keir M. Balla, Shanley N. Roach, Frances K. Shepherd, Dira S. Putri, Talia D. Wiggen, Stephen A. Goldstein, Mark J. Pierson, Martin T. Ferris, Claire E. Thefaine, Andrew Tucker, Mark Salnikov, Valerie Cortez, Susan R. Compton, Sergei V. Kotenko, Ryan C. Hunter, David Masopust, Nels C. Elde, Ryan A. Langlois
Publikováno v:
The Journal of experimental medicine, vol 219, iss 2
Emerging viruses threaten global health, but few experimental models can characterize the virus and host factors necessary for within- and cross-species transmission. Here, we leverage a model whereby pet store mice or rats—which harbor natural rod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90035b8476ecd46c6b00c7c9729ffc5
https://escholarship.org/uc/item/5t8270hs
https://escholarship.org/uc/item/5t8270hs
Autor:
Miles R Corley, Viviana A Dominguez, Katelyn T Nguyen, Brian V Tsu, Bindhu Hosuru, Elizabeth J Fay, Matthew D. Daugherty
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Many pathogens encode proteases that serve to antagonize the host immune system. In particular, viruses with a positive-sense single-stranded RNA genome [(+)ssRNA], including picornaviruses, flaviviruses, and coronaviruses, encode proteases that are
Autor:
Elizabeth J. Fay, Ryan A. Langlois
Publikováno v:
Non-Coding RNA, Vol 4, Iss 4, p 25 (2018)
Live-attenuated vaccines are the most effective way to establish robust, long-lasting immunity against viruses. However, the possibility of reversion to wild type replication and pathogenicity raises concerns over the safety of these vaccines. The us
Externí odkaz:
https://doaj.org/article/1eba449991be461ba4208d34dfbfb1e9
Autor:
Sathi Wijeyesinghe, Matthew W. Markman, David Masopust, Marissa Macchietto, Ian A. Stone, Ryan A. Langlois, Steven S. Shen, Jessica K. Fiege, Elizabeth J. Fay
Publikováno v:
J Immunol
Resident memory T cells (TRM) in the lung are vital for heterologous protection against influenza A virus (IAV). Environmental factors are necessary to establish lung TRM; however, the role of T cell–intrinsic factors like TCR signal strength have
Publikováno v:
Journal of Virology
Influenza A virus (IAV) is a respiratory pathogen that has caused significant mortality throughout history and remains a global threat to human health. Although much is known about IAV replication, the regulation of IAV replication dynamics is not co
Autor:
Gabriela L. Cosma, Ryan A. Langlois, Laurence C. Eisenlohr, Elizabeth J. Fay, Nicholas A. Siciliano, Jenna L. Lobby
Publikováno v:
Proc Natl Acad Sci U S A
Significance CD8 + T cells eliminate infections and cancers through recognition of antigen-derived peptides displayed at the cell surface in combination with MHC class I molecules. We show that a single glycoprotein-derived epitope is generated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9815298cc12f4c0c85db96ddb7219d08
https://europepmc.org/articles/PMC7430976/
https://europepmc.org/articles/PMC7430976/