Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Elizabeth J, Durhan"'
Autor:
Nancy D. Denslow, Quincy Teng, John M. Davis, Jason P. Berninger, Alvine C. Mehinto, Dalma Martinović-Weigelt, Kathleen M. Jensen, Drew R. Ekman, Carlie A. LaLone, Michael D. Kahl, Gerald T. Ankley, Evan Eid, Elizabeth J. Durhan, Daniel L. Villeneuve, Timothy W. Collette
Publikováno v:
Toxicological Sciences. 156:344-361
Cyclooxygenase (COX) inhibitors are ubiquitous in aquatic systems and have been detected in fish tissues. The exposure of fish to these pharmaceuticals is concerning because COX inhibitors disrupt the synthesis of prostaglandins (PGs), which modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d97b482dc627ca163300ff99d03cc9
https://doi.org/10.1093/toxsci/kfw257
https://doi.org/10.1093/toxsci/kfw257
Autor:
Elizabeth A. Makynen, Edward J. Perkins, Gerald T. Ankley, Natàlia Garcia-Reyero, Kathleen M. Jensen, Richard L. Leino, Elizabeth J. Durhan, Jenna E. Cavallin, Leah C. Wehmas, Daniel L. Villeneuve, Michael D. Kahl
Publikováno v:
Environmental Toxicology and Chemistry. 36:231-242
Triclocarban (TCC) is an antimicrobial agent routinely detected in surface waters that has been hypothesized to interact with the vertebrate endocrine system. The present study examined the effects of TCC alone and in combination with the model endoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ec15bfc4796b9d55f5dd431cd06588
https://doi.org/10.1002/etc.3531
https://doi.org/10.1002/etc.3531
Autor:
Daniel L. Villeneuve, Michael D. Kahl, Dalma Martinović-Weigelt, Barbara Lynn Escalon, Tanwir Habib, Edward J. Perkins, Elizabeth A. Makynen, Kathleen M. Jensen, Elizabeth J. Durhan, Gerald T. Ankley, Jenna E. Cavallin, Anthony L. Schroeder, Natàlia Garcia-Reyero
Cytochrome P450 aromatase catalyzes conversion of C19 androgens to C18 estrogens and is critical for normal reproduction in female vertebrates. Fadrozole is a model aromatase inhibitor that has been shown to suppress estrogen production in the ovarie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea913f13c2cfc68f3bd1e6c715f74d2
https://europepmc.org/articles/PMC6010346/
https://europepmc.org/articles/PMC6010346/
Autor:
Nicola Evans, Sara M. Seidl, Michael D. Kahl, Kathleen M. Jensen, Dana W. Kolpin, Linnea M. Thomas, Edward P. Kolodziej, Matthew A. Weberg, Elizabeth J. Durhan, Elizabeth A. Makynen, William T. Foreman, Daniel L. Villeneuve, Carlie A. LaLone, Vickie S. Wilson, Gerald T. Ankley, Jenna E. Cavallin
Publikováno v:
Environmental Toxicology and Chemistry. 33:1849-1857
Animal waste from livestock farming operations can contain varying levels of natural and synthetic androgens and/or estrogens, which can contaminate surrounding waterways. In the present study, surface stream water was collected from 6 basins contain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30566c9f4f601efb9f6a30e95b37cbea
https://doi.org/10.1002/etc.2627
https://doi.org/10.1002/etc.2627
Autor:
Jason P. Berninger, Gerald T. Ankley, Carlie A. LaLone, Anthony L. Schroeder, Kyle Stevens, Michael D. Kahl, Kathleen M. Jensen, Jenna E. Cavallin, Elizabeth A. Makynen, Meagan Hughes, Daniel L. Villeneuve, Bruce A. Holmen, Evan Eid, Elizabeth J. Durhan
Publikováno v:
Environmental Toxicology and Chemistry. 33:1584-1595
Assessment of potential risks of complex contaminant mixtures in the environment requires integrated chemical and biological approaches. In support of the US Great Lakes Restoration Initiative, the US Environmental Protection Agency lab in Duluth, MN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf536dd5be02660a92b1092b4f13de7c
https://doi.org/10.1002/etc.2591
https://doi.org/10.1002/etc.2591
Autor:
Jenna E. Cavallin, Daniel L. Villeneuve, Kathleen M. Jensen, Jessica J. Churchill, Michael D. Kahl, Rodney D. Johnson, Gerald T. Ankley, Elizabeth J. Durhan, Sarah Y. Skolness, Elizabeth A. Makynen, Chad A. Blanksma
Publikováno v:
Toxicological Sciences. 132:284-297
Conazoles are designed to inhibit cytochrome P450 (CYP) 14α-demethylase, an enzyme key to fungal cell wall formation. In vertebrates, conazoles may inhibit other CYPs, potentially disrupting processes like sex steroid synthesis. Propiconazole is a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4e6a971402ce5a4b455146e77f5ce4
https://doi.org/10.1093/toxsci/kft010
https://doi.org/10.1093/toxsci/kft010
Autor:
Rebecca Milsk, Dalma Martinović Weigelt, Daniel L. Villeneuve, Michael D. Kahl, Elizabeth J. Durhan, Elizabeth A. Makynen, Jenna E. Cavallin, N. D. Mueller, Gerald T. Ankley, Anthony L. Schroeder, Kathleen M. Jensen
Publikováno v:
Aquatic toxicology (Amsterdam, Netherlands). 180
The aim of this study was to investigate temporal changes in the hypothalamic-pituitary-gonadal (HPG) axis of fathead minnows (Pimephales promelas) treated with the model androgen receptor (AR) antagonist flutamide. Reproductively-mature fish were ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b56a1e547a0bf4122736b23f5fadcf
https://pubmed.ncbi.nlm.nih.gov/27716581
https://pubmed.ncbi.nlm.nih.gov/27716581
Autor:
Elizabeth A. Makynen, Gerald T. Ankley, Daniel L. Villeneuve, Michael D. Kahl, Natàlia Garcia-Reyero, Carlie A. LaLone, Kathleen M. Jensen, O. B. Adedeji, Elizabeth J. Durhan, Linnea M. Thomas, Edward J. Perkins
Publikováno v:
Environmental Science & Technology. 46:7826-7835
Diethylstilbestrol (DES) is a synthetic estrogen that has been banned for use in humans, but still is employed in livestock and aquaculture operations in some parts of the world. Detectable concentrations of DES in effluent and surface waters have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3a88b9e7b076379ecd49ab15024d20
https://doi.org/10.1021/es301043b
https://doi.org/10.1021/es301043b
Autor:
Linnea M. Thomas, Jenna E. Cavallin, Sara M. Seidl, Sarah Y. Skolness, Michael D. Kahl, Daniel L. Villeneuve, Leah C. Wehmas, Gerald T. Ankley, Rodney D. Johnson, Elizabeth A. Makynen, Elizabeth J. Durhan, Allen W. Olmstead, Kathleen M. Jensen, Elizabeth K. Medlock, Carlie A. LaLone, Chad A. Blanksma
Publikováno v:
Environmental Toxicology and Chemistry. 31:611-622
Synthetic glucocorticoids are pharmaceutical compounds prescribed in human and veterinary medicine as anti-inflammatory agents and have the potential to contaminate natural watersheds via inputs from wastewater treatment facilities and confined anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8835e0bbf126b7ff01c5bfdd5254810
https://doi.org/10.1002/etc.1729
https://doi.org/10.1002/etc.1729
Autor:
Michael D. Kahl, Kathleen M. Jensen, Dalma Martinović-Weigelt, Elizabeth J. Durhan, Daniel L. Villeneuve, Gerald T. Ankley, Jenna E. Cavallin, Leah C. Wehmas, Elizabeth A. Makynen
Publikováno v:
Environmental Toxicology and Chemistry. 30:2094-2102
Inhibition of enzymes involved in the synthesis of sex steroids can substantially impact developmental and reproductive processes controlled by the hypothalmic-pituitary-gonadal (HPG) axis. A key steroidogenic enzyme that has received little attentio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da6b0fabbddc66d9e68db82a01c842a
https://doi.org/10.1002/etc.593
https://doi.org/10.1002/etc.593