Výsledky vyhledávání - "Elizabeth I. Harding"

Synthesis of Potent Leukotriene A4 Hydrolase Inhibitors. Identification of 3-[Methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic Acid

Autor: Walter G. Smith, Suzanne H Kim, Doreen Villani-Price, Matthew W Mahoney, Nayereh S Ghoreishi-Haack, Helen Y. Chen, Thomas D. Penning, Stella Siu-Tzyy Yu, James W. Malecha, Leslie J Askonas, Chi-Dean Liang, Elizabeth I Harding, E.Yvonne Pyla, Maureen K Highkin, James K. Gierse, Julie M Miyashiro, Mark A Russell, James F Kachur, Chen Barbara B

Publikováno v: Journal of Medicinal Chemistry. 45:3482-3490

Leukotriene B(4) (LTB(4)) is a potent, proinflammatory mediator involved in the pathogenesis of a number of diseases including inflammatory bowel disease, psoriasis, rheumatoid arthritis, and asthma. The enzyme LTA(4) hydrolase represents an attracti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49aaaeb42023ad7fd78de02ecc724a97
https://doi.org/10.1021/jm0200916

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Structure−Activity Relationship Studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a Potent Inhibitor of Leukotriene A4 (LTA4) Hydrolase

Publikováno v: Journal of Medicinal Chemistry. 43:721-735

Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. Since the action of LTA(4) hydrolase is the rate-limiting step for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2c8b8f857645ec82bda0e73ed60429
https://doi.org/10.1021/jm990496z

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Synthesis of Imidazopyridines and Purines as Potent Inhibitors of Leukotriene A4 Hydrolase

Autor: Doreen Villani-Price, Suzanne H Kim, Walter G. Smith, Leslie J Askonas, Elizabeth I Harding, Maureen K Highkin, Thomas D. Penning, Alan F. Gasiecki, Nayereh S Ghoreishi-Haack, Nizal S Chandrakumar, E.Yvonne Pyla, Bipin N Desai, James F Kachur, Mark A Russell, Stevan W Djuric, James W. Malecha, James K. Gierse, Julie M Miyashiro

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 13:1137-1139

The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excelle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830ee52b64cb2d30d9d134d0185d9a9
https://doi.org/10.1016/s0960-894x(03)00039-8

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Pyrrolidine and piperidine analogues of SC-57461A as potent, orally active inhibitors of leukotriene A(4) hydrolase

Autor: Maureen K Highkin, Leslie J Askonas, Doreen Villani-Price, Chi-Dean Liang, Bipin N Desai, Thomas D. Penning, James F Kachur, Elizabeth I Harding, Nayereh S Ghoreishi-Haack, Mark A Russell, Julie M Miyashiro, Walter G. Smith, E.Yvonne Pyla, Nizal S Chandrakumar, Stevan W Djuric, Suzanne H Kim, James K. Gierse, Alan F. Gasiecki

Publikováno v: Bioorganicmedicinal chemistry letters. 12(23)

The synthesis and biological evaluation of a series of functionalized pyrrolidine- and piperidine-containing analogues of our lead LTA(4) hydrolase inhibitor, SC-57461A, is described. A number of compounds showed excellent potency in our in vitro scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bec3c88d96d40830db918a67cb8307f
https://pubmed.ncbi.nlm.nih.gov/12419366

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Messenger RNA encoding a glutathione-S-transferase responsible for herbicide tolerance in maize is induced in response to safener treatment

Autor: Ernest G. Jaworski, Elizabeth I. Harding, Judith Arlene Diaz-Collier, David C. Tiemeier, Roger C. Wiegand, Court Saunders, Dilip M. Shah, Thomas J. Mozer

Publikováno v: Plant Molecular Biology. 7:235-243

Glutathione-S-transferases (GST's) in maize represent a family of enzymes which conjugate glutathione to several major classes of pre-emergent, selective herbicides. Chemicals termed safeners have been demonstrated to increase the tolerance of maize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8013c8e2be3177ef17210dadecf1021b
https://doi.org/10.1007/bf00752897

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Structural analysis of a maize gene coding for glutathione-S-transferase involved in herbicide detoxification

Autor: Dilip M. Shah, Gwen G. Krivi, Elizabeth I. Harding, Roger C. Wiegand, Cathy M. Hironaka, David C. Tiemeier

Publikováno v: Plant molecular biology. 6(4)

We have used the cDNA clone encoding maize glutathione-S-transferase (GST I) to isolate a genomic DNA clone containing the complete GST I gene. Nucleotide sequence analysis of the cDNA and genomic clones has yielded a complete amino acid sequence for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ce897be6685e75d1c40b0a15e40c94
https://pubmed.ncbi.nlm.nih.gov/24307319

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