Výsledky vyhledávání - "Elizabeth Hussey"

Akademický článek

Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8

Autor: Andreas Port, Jamie V. Shaw, Lena Klopp‐Schulze, Afrim Bytyqi, Claudia Vetter, Elizabeth Hussey, Nadra Mammasse, Victor Ona, Angelika Bachmann, Denis Strugala, Christian Reh, Kosalaram Goteti

Publikováno v: Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)

Abstract This study evaluated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of enpatoran (formerly named M5049), a new toll‐like receptor (TLR) 7 and 8 dual antagonist, and the effect o

Externí odkaz: https://doaj.org/article/8b6bac10490c420498e14c91c2474382

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Akademický článek

Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with advanced solid tumors

Autor: Sen Zhang, Jacques Moisan, Aung Naing, Kyriakos P Papadopoulos, Elizabeth Hussey, Joseph P Eder, Sarina A Piha-Paul, Claude Gimmi, Vera Hildebrand, Vinayak Hosagrahara, Christina Habermehl

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background M4112 is an oral, potent, and selective indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase 2 (TDO2) dual inhibitor. Here, we report preclinical data and first-in-human phase I data, including safety, tolerability, pharmaco

Externí odkaz: https://doaj.org/article/19df87857bc4405d817bc7e523a5fcc1

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Akademický článek

Exploring glycosuria as a mechanism for weight and fat mass reduction. A pilot study with remogliflozin etabonate and sergliflozin etabonate in healthy obese subjects

Autor: Antonella Napolitano, Sam Miller, Peter R. Murgatroyd, Elizabeth Hussey, Robert L. Dobbins, Edward T. Bullmore, Derek J.R. Nunez

Publikováno v: Journal of Clinical & Translational Endocrinology, Vol 1, Iss 1, Pp e3-e8 (2014)

Inhibitors of sodium-dependent glucose co-transporter 2 (SGLT2) increase glucose excretion in the urine and improve blood glucose in Type 2 diabetes mellitus. Glycosuria provides an energy and osmotic drain that could alter body composition. We there

Externí odkaz: https://doaj.org/article/6b472b7c565f46638093142889ba81e0

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Assessment of safety and tolerability of remogliflozin etabonate (GSK189075) when administered with total daily dose of 2000 mg of metformin

Autor: Barkate Hanmant, Robert Dobbins, Susan Andrews, Bentley Cheatham, Robin O'Connor-Semmes, Elizabeth Hussey, Katare Sagar, Wenli Tao, William O. Wilkison

Publikováno v: BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-11 (2021)
BMC Pharmacology & Toxicology

Background Patients with type 2 diabetes mellitus (T2DM) are characterized by an elevated glycemic index and are at a higher risk for complications such as cardiovascular disease, nephropathy, retinopathy and peripheral neuropathy. Normalization of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bc3a4e5498b39d7a1a70581e976409b
https://doaj.org/article/ee619324b38a44d88d714cf84257f4f3

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Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8

Autor: Afrim Bytyqi, Denis Strugala, Lena Klopp‐Schulze, Victor Ona, Elizabeth Hussey, Jamie V. Shaw, Andreas Port, Kosalaram Goteti, Christian Reh, Nadra Mammasse, Angelika Bachmann, Claudia Vetter

Publikováno v: Pharmacology Research & Perspectives, Vol 9, Iss 5, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives

This study evaluated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple oral doses of enpatoran (formerly named M5049), a new toll‐like receptor (TLR) 7 and 8 dual antagonist, and the effect of food on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd23f4b72b4f542b1bb30ad6fc4485af
https://doi.org/10.1002/prp2.842

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P135 A phase I, first-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of single and multiple ascending doses of M5049, a dual antagonist of TLR7/8, in healthy subjects

Autor: Christian Reh, Elizabeth Hussey, Ying Zhang, Lena Klopp‐Schulze, Angelika Bachmann, Kosalaram Goteti, Andreas Port, Nadra Mammasse, Jamie Shaw

Publikováno v: Poster presentations.

Background Toll-like receptors 7 and 8 (TLR7/8) are widely expressed in a variety of immune cells and detect single-stranded RNAs, activating signalling cascades which trigger an immune response. Aberrant TLR7/8 activation by RNA-containing autoantib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dfc981c671e1eebbb5623a3786fe792
https://doi.org/10.1136/lupus-2020-eurolupus.179

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Mazindol: a risk factor for pulmonary arterial hypertension?

Autor: Christophe Delclaux, Elizabeth Hussey, Eric Konofal, Cherine Benzouid, Michel Lecendreux

Publikováno v: Sleep medicine. 34

Mazindol is an imidazo-isoindole derivative, a tricyclic compound and a non-amphetamine central nervous system stimulant that blocks dopamine and norepinephrine reuptake. Mazindol was withdrawn from the US and European markets in 1999 for reasons unr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4640c358d632f841bb87dd44a7fd987
https://pubmed.ncbi.nlm.nih.gov/28522087

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Object-Based Attentional Modulation of Biological Motion Processing: Spatiotemporal Dynamics Using Functional Magnetic Resonance Imaging and Electroencephalography

Autor: Raja Parasuraman, Elizabeth Hussey, James C. Thompson, Ashley Safford

Publikováno v: Journal of Neuroscience. 30:9064-9073

Although it is well documented that the ability to perceive biological motion is mediated by the lateral temporal cortex, whether and when neural activity in this brain region is modulated by attention is unknown. In particular, it is unclear whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e7ca087e8138fe5c9eb791d7ed0c65
https://doi.org/10.1523/jneurosci.1779-10.2010

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Detecting threat-related intentional actions of others: effects of image quality, response mode, and target cuing on vigilance

Autor: Raja Parasuraman, Elizabeth Hussey, Tyler H. Shaw, Ewart J. de Visser, James C. Thompson, W. Ryan McGarry, Ellen Clarke

Publikováno v: Journal of experimental psychology. Applied. 15(4)

Three experiments examined the vigilance performance of participants watching videos depicting intentional actions of an individual's hand reaching for and grasping an object--involving transporting or using either a gun or a hairdryer--in order to d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740ebfbecd73dc763fb2f02ef1432919
https://pubmed.ncbi.nlm.nih.gov/20025415

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Perception of Facial Expression in Somatosensory Cortex Supports Simulationist Models

Autor: Ashley Safford, Elizabeth Hussey

Publikováno v: The Journal of Neuroscience. 29:301-302

Theories of embodied cognition propose that recognizing facial expressions requires visual processing followed by simulation of the somatovisceral responses associated with the perceived expression. To test this proposal, we targeted the right occipi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3176207dee0c44254d0e49fb0c93fd6b
https://doi.org/10.1523/jneurosci.5205-08.2009

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