Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Elizabeth Harley"'
Autor:
Patricia Rueda, Elizabeth Harley, Yao Lu, Gregory D Stewart, Stewart Fabb, Natalie Diepenhorst, Béatrice Cremers, Marie-Hélène Rouillon, Isabelle Wehrle, Anne Geant, Gwladys Lamarche, Katie Leach, William N Charman, Arthur Christopoulos, Roger J Summers, Patrick M Sexton, Christopher J Langmead
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146846 (2016)
Phenotyping of Gprc6a KO mice has shown that this promiscuous class C G protein coupled receptor is variously involved in regulation of metabolism, inflammation and endocrine function. Such effects are described as mediated by extracellular calcium,
Externí odkaz:
https://doaj.org/article/b658292f3cbd438ca68f91442b0499b5
Autor:
Perron-Sierra Françoise, Audrey Caliez, Solo Goldstein, Catherine Ilic, Jean-Olivier Rolin, Alain Ktorza, Elizabeth Harley, Frédéric De Ceuninck, Yves Charton, Catherine Kargar, Marjorie Sadlo, Cédric Vinson
Publikováno v:
British Journal of Pharmacology. 169:999-1010
Background and Purpose Small molecule glucokinase activators (GKAs) have been associated with potent antidiabetic efficacy and hepatic steatosis in rodents. This study reports the discovery of S 50131 and S 51434, two novel GKAs with an original scaf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c41e8dab1ccb5dc6132412fd6ea96ac
https://doi.org/10.1111/bph.12172
https://doi.org/10.1111/bph.12172
Autor:
Frédéric De Ceuninck, Cédric Vinson, András Kotschy, Jean-Marie Fourquez, Michel Wierzbicki, Jean-Olivier Rolin, Olivier Broux, Marjorie Sadlo, Brant de Fanti, Catherine Kargar, Thierry Umbdenstock, Elizabeth Harley, Audrey Caliez, Anne-Laure Lefèvre, Perron-Sierra Françoise, Catherine Ilic, Alain Ktorza, Murielle Combettes
Publikováno v:
British Journal of Pharmacology. 168:339-353
Background and Purpose Small-molecule glucokinase activators (GKAs) are currently being investigated as therapeutic options for the treatment of type 2 diabetes (T2D). Because liver overexpression of glucokinase is thought to be associated with alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aad602b4d72163170d2597a22809461
https://doi.org/10.1111/j.1476-5381.2012.02184.x
https://doi.org/10.1111/j.1476-5381.2012.02184.x
Autor:
Gwladys Lamarche, Anne Géant, Natalie Diepenhorst, Christopher J. Langmead, Stewart A. Fabb, Patricia Rueda, Yao Lu, William N. Charman, Elizabeth Harley, Béatrice Cremers, Isabelle Wehrle, Katie Leach, Marie-Hélène Rouillon, Arthur Christopoulos, Gregory D. Stewart, Patrick M. Sexton, Roger J. Summers
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 1, p e0146846 (2016)
PLoS ONE, Vol 11, Iss 1, p e0146846 (2016)
Phenotyping of Gprc6a KO mice has shown that this promiscuous class C G protein coupled receptor is variously involved in regulation of metabolism, inflammation and endocrine function. Such effects are described as mediated by extracellular calcium,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95653ff87c1b531cdeb16ebf8e328a8b
https://doi.org/10.1371/journal.pone.0146846
https://doi.org/10.1371/journal.pone.0146846