Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Elizabeth H. Kellogg"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Deciphering the relationship between a gene and its genomic context is fundamental to understanding and engineering biological systems. Machine learning has shown promise in learning latent relationships underlying the sequence-structure-fun
Externí odkaz:
https://doaj.org/article/e89d2e92e119410faf6ff04cf3e744c7
Autor:
Arica R. VanderWal, Jung-Un Park, Bogdan Polevoda, Julia K. Nicosia, Adrian M. Molina Vargas, Elizabeth H. Kellogg, Mitchell R. O’Connell
Publikováno v:
Science. 380:410-415
Type VI CRISPR-Cas systems use RNA-guided ribonuclease (RNase) Cas13 to defend bacteria against viruses, and some of these systems encode putative membrane proteins that have unclear roles in Cas13-mediated defense. We show that Csx28, of type VI-B2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6661f16cd7d26a7c4ea0abac79ab603
https://doi.org/10.1126/science.abm1184
https://doi.org/10.1126/science.abm1184
Autor:
Jung-Un Park, Amy Wei-Lun Tsai, Alexandrea N. Rizo, Vinh H. Truong, Tristan X. Wellner, Richard D. Schargel, Elizabeth H. Kellogg
CRISPR-associated transposons (CAST) are programmable mobile genetic elements that insert large DNA cargos using an RNA-guided mechanism1–3. CAST elements contain multiple conserved proteins: a CRISPR effector (Cas12k or Cascade), a AAA+ regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773d5221e2a5a8c1f717d9ee09aa8009
https://doi.org/10.1101/2022.10.12.511933
https://doi.org/10.1101/2022.10.12.511933
Autor:
Elizabeth H. Kellogg, Jonathan Gootenberg, Omar Abudayyeh, Alan S.L. Wong, James E. Dahlman, Audrone Lapinaite, Cameron Myhrvold, Chang C. Liu, Patrick D. Hsu, Prashant Mali, Lei Stanley Qi
Publikováno v:
Cell systems. 13(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e253c7954710126964614864bcddd01
https://pubmed.ncbi.nlm.nih.gov/35981511
https://pubmed.ncbi.nlm.nih.gov/35981511
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(32)
CRISPR-associated transposons (CASTs) are Tn7-like elements that are capable of RNA-guided DNA integration. Although structural data are known for nearly all core transposition components, the transposase component, TnsB, remains uncharacterized. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa291bb2a1e9843871faab60d097348
https://pubmed.ncbi.nlm.nih.gov/35914146
https://pubmed.ncbi.nlm.nih.gov/35914146
Publikováno v:
J Chem Inf Model
Cryo-electron microscopy (cryo-EM) has enjoyed an explosive recent growth due to revolutionary advances in hardware and software, resulting in a steady stream of long-awaited, high-resolution structures with unprecedented atomic detail. With this com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544427731be9ce40e3cfa05d4c61e95d
https://doi.org/10.1021/acs.jcim.9b01178
https://doi.org/10.1021/acs.jcim.9b01178
Autor:
Arica R. VanderWal, Jung-Un Park, Bogdan Polevoda, Julia K. Nicosia, Adrian M. Molina Vargas, Elizabeth H. Kellogg, Mitchell R. O'Connell
Publikováno v:
Biophysical Journal. 122:194a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::872df3c95ca76a9c0f7f05309abeb855
https://doi.org/10.1016/j.bpj.2022.11.1183
https://doi.org/10.1016/j.bpj.2022.11.1183
CRISPR-Csx28 forms a Cas13b-activated membrane pore required for robust CRISPR-Cas adaptive immunity
Autor:
Arica R. VanderWal, Jung-Un Park, Bogdan Polevoda, Elizabeth H. Kellogg, Mitchell R. O’Connell
Type VI CRISPR-Cas systems use the RNA-guided RNase Cas13 to defend bacteria against viruses, and some of these systems encode putative membrane proteins that have unclear roles in Cas13-mediated defense. Here we show that Csx28, of Type VI-B2 system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da0d64121fa4440962f7ce067cadc60
https://doi.org/10.1101/2021.11.02.466367
https://doi.org/10.1101/2021.11.02.466367
Autor:
Michael T. Petassi, Amy Tsai, Jung-Un Park, Eshan Mehrotra, Shan-Chi Hsieh, Elizabeth H. Kellogg, Joseph E. Peters, Ailong Ke
Publikováno v:
Science
CRISPR-associated transposition systems allow guide RNA-directed integration of a single DNA cargo in one orientation at a fixed distance from a programmable target sequence. We used cryo-electron microscopy (cryo-EM) to define the mechanism that und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0715213cc1f88ce97e50fdba1766e4
https://doi.org/10.1016/j.bpj.2021.11.1096
https://doi.org/10.1016/j.bpj.2021.11.1096
Structure of a P element transposase–DNA complex reveals unusual DNA structures and GTP-DNA contacts
Publikováno v:
Nature Structural & Molecular Biology. 26:1013-1022
P element transposase catalyzes the mobility of P element DNA transposons within the Drosophila genome. P element transposase exhibits several unique properties, including the requirement for a guanosine triphosphate cofactor and the generation of lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6927e7924f8df097af67cc7dc9e59674
https://doi.org/10.1038/s41594-019-0319-6
https://doi.org/10.1038/s41594-019-0319-6