Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Elizabeth H Mann"'
Autor:
Paul E Pfeffer, Haw Lu, Elizabeth H Mann, Yin-Huai Chen, Tzer-Ren Ho, David J Cousins, Chris Corrigan, Frank J Kelly, Ian S Mudway, Catherine M Hawrylowicz
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200040 (2018)
BACKGROUND:Particulate matter (PM) pollutant exposure, which induces oxidative stress and inflammation, and vitamin D insufficiency, which compromises immune regulation, are detrimental in asthma. OBJECTIVES:Mechanistic cell culture experiments were
Externí odkaz:
https://doaj.org/article/f3d696009af0456f861023d1f64c4a4a
Autor:
Carl-Philipp Hackstein, Dana Costigan, Linnea Drexhage, Claire Pearson, Samuel Bullers, Nicholas Ilott, Hossain Delowar Akther, Yisu Gu, Michael E. B. FitzPatrick, Oliver J. Harrison, Lucy C. Garner, Elizabeth H. Mann, Sumeet Pandey, Matthias Friedrich, Nicholas M. Provine, Holm H. Uhlig, Emanuele Marchi, Fiona Powrie, Paul Klenerman, Emily E. Thornton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Interactions between the host immune response and the commensal microbiota play essential roles in health and disease. Here the authors identify a population of MHC class II, innate like, commensal reactive cells in the gut of mice and humans.
Externí odkaz:
https://doaj.org/article/7533503d8e2b41c48a9f686bb5ff0167
Autor:
Fiona Powrie, Nathaniel R. West, Timothy S. Maughan, Sabine Tejpar, Mauro Delorenzi, Viktor Hendrik Koelzer, Enric Domingo, Lucy C. Garner, Alina Janney, Samuel J. Bullers, Matthias Friedrich, Elizabeth H. Mann, David Barras, Sarah McCuaig
Supplementary data to accompany manuscript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256afe9c5d999b45e2a461687da65952
https://doi.org/10.1158/1078-0432.22472964.v1
https://doi.org/10.1158/1078-0432.22472964.v1
Autor:
Fiona Powrie, Nathaniel R. West, Timothy S. Maughan, Sabine Tejpar, Mauro Delorenzi, Viktor Hendrik Koelzer, Enric Domingo, Lucy C. Garner, Alina Janney, Samuel J. Bullers, Matthias Friedrich, Elizabeth H. Mann, David Barras, Sarah McCuaig
Purpose:The cytokine IL22 promotes tumor progression in murine models of colorectal cancer. However, the clinical significance of IL22 in human colorectal cancer remains unclear. We sought to determine whether the IL22 pathway is associated with prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e256db4ebac10aad0fd91efdd433e9
https://doi.org/10.1158/1078-0432.c.6528384
https://doi.org/10.1158/1078-0432.c.6528384
Autor:
Kevin Rue-Albrecht, Hannah Sharpe, Matthew A. Jackson, E Collantes, A P Frei, Alistair Easton, Fiona Powrie, M Coles, Christopher D. Buckley, Watts Gfm., Holm H. Uhlig, Simon Travis, Sarah McCuaig, M Brenner, Stephen N. Sansom, R Ravindran, Matthias Friedrich, R Tandon, Moustafa Attar, Ilya Korsunsky, Kevin Wei, T Thomas, F Barone, L Thomas, R S Peres, Samuel J. Bullers, Z Christoforidou, K G Lassen, Alessandra Geremia, Elizabeth H. Mann, Soumya Raychaudhuri, Mathilde Pohin, D Sathananthan
Publikováno v:
Nature Medicine
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in situ localization across three cohorts of patients with IBD (total
Publikováno v:
Nature. 585:509-517
Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium that is characterized by the accumulation of mutations and a dysregulated immune response. Up to 90% of disease risk is thought to be due to environmental factors such as
Publikováno v:
Mann, E H, Gabryšová, L, Pfeffer, P E, O’Garra, A & Hawrylowicz, C M 2019, ' High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17 + IL-10 + Memory CD4 + T Cell Response towards a Single IL-10–Producing Phenotype ', The Journal of Immunology, vol. 202, no. 3, ji1800697, pp. 684-693 . https://doi.org/10.4049/jimmunol.1800697
Glucocorticoids are known to increase production of the anti-inflammatory cytokine IL-10, and this action is associated with their clinical efficacy in asthmatics. However, glucocorticoids also enhance the synthesis of IL-17A by PBMCs, which, in exce
Autor:
Kevin Wei, Moustafa Attar, Ilya Korsunsky, T Thomas, Elizabeth H. Mann, Fiona Powrie, Holm H. Uhlig, Sarah McCuaig, Mathilde Pohin, Stephen N. Sansom, R S Peres, Matthias Friedrich, E Collantes, R Ravindran, Alistair Easton, Simon Travis, Kevin Rue-Albrecht, Soumya Raychaudhuri, D Sathananthan, L Thomas, Samuel J. Bullers, Watts Gfm., Z Christoforidou, Hannah Sharpe, Matthew A. Jackson, Alessandra Geremia
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology, and in situ localisation, we describe heterogeneity of the tissular infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57997cfc72d9d403e0a195267dbbaca9
https://doi.org/10.1101/2021.02.05.429804
https://doi.org/10.1101/2021.02.05.429804
Autor:
Tehmina Bharuchq, Bruce MacLachlan, Ceri Fielding, Adrian L Smith, Fadi Issa, Emily Thornton, Raphael Sanches Peres, Calliope A Dendrou, Dorothée L Berthold, Liliana Cifuentes, Alicia Teijeira Crespo, Elizabeth H Mann, Arvind Sami, Anne Chauveau, Dominic S Alonzi, Anís Gammage, Fabian Fischer, Valentina M T Bart, Fangfang Lu, Miriam O'Hanlon, Lynn B Dustin, Pragati Sabberwal, Ewoud B. Compeer, Mariana Borsa, Rowie Borst, Hannah Almuttaqi, David J Ahern, Eleanor J Pring, Emma Jones, Ester Gea-Mallorquí, Kate Liddiard, Dingxi Zhou, Amy Cross, Sara Danielli, Max Quastel, Shayda Maleki-Toyserkani, Owen R Moon, Ruban Rex Peter Durairaj, Vicky Batchelor, Barbora Schonfeldova, Angus K T Wann, Lorenzo Capitani, Petros Ligoxygakis, Sandra Dimonte, Clara Eléonore Pavillet, Lion F K Uhl, Luke C Davies, Kristin Ladell, Stephanie Jean Hanna, Felix Richter, Freya R Shepherd, Sarah Hulin-Curtis, Stephanie Burnell, Amy Susan Codd, Anita Milicic, Quentin Sattentau, Juliane Brun, David Oliver Scourfield, Sophie Reed, Jan Rehwinkel, Ghada Alsaleh, D Oliver Scourfield, Michael Tellier, Reginald James Matthews, Eleanor Pring, Emma Mitchell, Anna Katharina Simon, Joseph D Wilson, Niamh Richmond, Van Dien Nguyen, Sarah N Lauder, Zihan Zhu, Tharini A Selvakumar, Ana Pires, Cariad Shorten, Richard Williams, Erinke van Grinsven, Sarah Galloway, Aljawharah Alrubayyi, Stephanie J. Hanna, Felix Clemens Richter, Julie M Mazet, Dimitra Peppa, Clarissa Coveney, Awen Gallimore, Cornelia Heuberger, Owen Moon, Ruth Jones, Helene Borrmann, Arthur Dyer, Lucy Chapman, Jelena S Bezbradica, Andrew Godkin, Rebecca Bayliss, Amy S. Codd, Anna M Marzeda, Athena Cavounidis, Patrícia R S Rodrigues, Alice J B Robinson, Ewoud Bernardus Compeer
Publikováno v:
Oxford Open Immunology
Destabilization of balanced immune cell numbers and frequencies is a common feature of viral infections. This occurs due to, and further enhances, viral immune evasion and survival. Since the discovery of the Severe Acute Respiratory Syndrome coronav
Autor:
Elizabeth H. Mann, Catherine M. Hawrylowicz, Tak H. Lee, Paul E Pfeffer, Nick C Matthews, Christopher Corrigan, Frank J. Kelly
Exposure to urban particulate matter (UPM) exacerbates asthmatic lung inflammation. Lung dendritic cells (DCs) are critical for stimulating T cell immunity and in maintaining airway tolerance, but they also react to airway UPM. The adjuvant role of U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f71067ca7cbe44bafdf755984899a1
https://ora.ox.ac.uk/objects/uuid:03bfcfc2-2729-4559-8ef1-f3e1902c0d70
https://ora.ox.ac.uk/objects/uuid:03bfcfc2-2729-4559-8ef1-f3e1902c0d70