Zobrazeno 1 - 10
of 370
pro vyhledávání: '"Elizabeth H Blackburn"'
Autor:
David H Rehkopf, Belinda L Needham, Jue Lin, Elizabeth H Blackburn, Ami R Zota, Janet M Wojcicki, Elissa S Epel
Publikováno v:
PLoS Medicine, Vol 13, Iss 11, p e1002188 (2016)
Leukocyte telomere length (LTL) is a putative biological marker of immune system age, and there are demonstrated associations between LTL and cardiovascular disease. This may be due in part to the relationship of LTL with other biomarkers associated
Externí odkaz:
https://doaj.org/article/f9f987dcf5854cbf8159015211558778
Autor:
Sarah E Goglin, Ramin Farzaneh-Far, Elissa S Epel, Jue Lin, Elizabeth H Blackburn, Mary A Whooley
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168868 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0160748.].
Externí odkaz:
https://doaj.org/article/77ee09a3315f41e18247e02f8d33c063
Autor:
Sarah E Goglin, Ramin Farzaneh-Far, Elissa S Epel, Jue Lin, Elizabeth H Blackburn, Mary A Whooley
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0160748 (2016)
Short telomere length independently predicts mortality in patients with coronary heart disease. Whether 5-year change in telomere length predicts subsequent mortality in patients with coronary heart disease has not been evaluated.In a prospective coh
Externí odkaz:
https://doaj.org/article/0f1f54b968074f09b924fffdfe279e30
Autor:
Emily G Jacobs, Candyce Kroenke, Jue Lin, Elissa S Epel, Heather A Kenna, Elizabeth H Blackburn, Natalie L Rasgon
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54713 (2013)
Apolipoprotein-ε4 (APOE-ε4) is a major genetic risk factor for cognitive decline, Alzheimer's disease (AD) and early mortality. An accelerated rate of biological aging could contribute to this increased risk. Here, we determined whether APOE-ε4 st
Externí odkaz:
https://doaj.org/article/7c3dae51c75e4a88b13a8b31f533b70a
Autor:
Owen M Wolkowitz, Synthia H Mellon, Elissa S Epel, Jue Lin, Firdaus S Dhabhar, Yali Su, Victor I Reus, Rebecca Rosser, Heather M Burke, Eve Kupferman, Mariana Compagnone, J Craig Nelson, Elizabeth H Blackburn
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17837 (2011)
Depression is associated with an unusually high rate of aging-related illnesses and early mortality. One aspect of "accelerated aging" in depression may be shortened leukocyte telomeres. When telomeres critically shorten, as often occurs with repeate
Externí odkaz:
https://doaj.org/article/0a688fa0a230445fb4327c5e33cc4443
Autor:
Aoife O'Donovan, Matthew S Pantell, Eli Puterman, Firdaus S Dhabhar, Elizabeth H Blackburn, Kristine Yaffe, Richard M Cawthon, Patricia L Opresko, Wen-Chi Hsueh, Suzanne Satterfield, Anne B Newman, Hilsa N Ayonayon, Susan M Rubin, Tamara B Harris, Elissa S Epel, Health Aging and Body Composition Study
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19687 (2011)
Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells
Externí odkaz:
https://doaj.org/article/38107a059a4e4a15bc597547864e6284
Autor:
Omer T Njajou, Elizabeth H Blackburn, Ludmila Pawlikowska, Massimo Mangino, Coleen M Damcott, Pui-Yan Kwok, Timothy D Spector, Anne B Newman, Tamara B Harris, Steven R Cummings, Richard M Cawthon, Alan R Shuldiner, Ana M Valdes, Wen-Chi Hsueh
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e13048 (2010)
Telomeres shorten as cells divide. This shortening is compensated by the enzyme telomerase. We evaluated the effect of common variants in the telomerase RNA component (TERC) gene on telomere length (TL) in the population-based Health Aging and Body C
Externí odkaz:
https://doaj.org/article/e1b282bfb9a84642821e61442a210658
Autor:
Ryan Rampersaud, Gwyneth W. Y. Wu, Victor I. Reus, Jue Lin, Elizabeth H. Blackburn, Elissa S. Epel, Christina M. Hough, Synthia H. Mellon, Owen M. Wolkowitz
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Telomere length (TL) is a marker of biological aging, and shorter telomeres have been associated with several medical and psychiatric disorders, including cardiometabolic dysregulation and Major Depressive Disorder (MDD). In addition, studie
Externí odkaz:
https://doaj.org/article/eced414471ba40eebb992e5b4b44aa9b
Human telomerase reverse transcriptase (hTERT; the catalytic protein subunit of telomerase) is subjected to numerous alternative splicing events, but the regulation and function of these splice variants is obscure. Full-length hTERT includes conserve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5bc043ec63b87a2d2c2030f124da7ee
https://doi.org/10.1158/0008-5472.c.6505496
https://doi.org/10.1158/0008-5472.c.6505496
PDF file - 516K, T1. Breast cell lines used in this study. T2. Summary of results for 45 breast cancer cell lines and 5 non-malignant cell lines. T3. Correlation of hTERT α/β splice variants, telomerase activity, telomere length and hTR in 50 breas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6cdc16655514655afd699a2a0e29097
https://doi.org/10.1158/0008-5472.22400087.v1
https://doi.org/10.1158/0008-5472.22400087.v1