Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Elizabeth Guruceaga"'
Autor:
Ander Puyalto, María Rodríguez-Remírez, Inés López, Irati Macaya, Elizabeth Guruceaga, María Olmedo, Anna Vilalta-Lacarra, Connor Welch, Sergio Sandiego, Silvestre Vicent, Karmele Valencia, Alfonso Calvo, Ruben Pio, Luis E. Raez, Christian Rolfo, Daniel Ajona, Ignacio Gil-Bazo
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-19 (2024)
Abstract Background The identification of novel therapeutic strategies to overcome resistance to the MEK inhibitor trametinib in mutant KRAS lung adenocarcinoma (LUAD) is a challenge. This study analyzes the effects of trametinib on Id1 protein, a ke
Externí odkaz:
https://doaj.org/article/a7f566efdb754d68bd28062af5ab4148
Autor:
Ana Patiño-García, Elizabeth Guruceaga, Maria Pilar Andueza, Marimar Ocón, Jafait Junior Fodop Sokoudjou, Nicolás de Villalonga Zornoza, Gorka Alkorta-Aranburu, Ibon Tamayo Uria, Alfonso Gurpide, Carlos Camps, Eloísa Jantus-Lewintre, Maria Navamuel-Andueza, Miguel F. Sanmamed, Ignacio Melero, Mohamed Elgendy, Juan Pablo Fusco, Javier J. Zulueta, Juan P. de-Torres, Gorka Bastarrika, Luis Seijo, Ruben Pio, Luis M. Montuenga, Mikel Hernáez, Idoia Ochoa, Jose Luis Perez-Gracia
Publikováno v:
EBioMedicine, Vol 102, Iss , Pp 105048- (2024)
Summary: Background: Tobacco is the main risk factor for developing lung cancer. Yet, while some heavy smokers develop lung cancer at a young age, other heavy smokers never develop it, even at an advanced age, suggesting a remarkable variability in t
Externí odkaz:
https://doaj.org/article/325b5d8d436b42f0be4be23054440e34
Autor:
Irati Macaya, Marta Roman, Connor Welch, Rodrigo Entrialgo-Cadierno, Marina Salmon, Alba Santos, Iker Feliu, Joanna Kovalski, Ines Lopez, Maria Rodriguez-Remirez, Sara Palomino-Echeverria, Shane M. Lonfgren, Macarena Ferrero, Silvia Calabuig, Iziar A. Ludwig, David Lara-Astiaso, Eloisa Jantus-Lewintre, Elizabeth Guruceaga, Shruthi Narayanan, Mariano Ponz-Sarvise, Antonio Pineda-Lucena, Fernando Lecanda, Davide Ruggero, Purvesh Khatri, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Irene Ferrer, Luis Paz-Ares, Matthias Drosten, Mariano Barbacid, Ignacio Gil-Bazo, Silve Vicent
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the context of KRAS-mutat
Externí odkaz:
https://doaj.org/article/e4df0207a07b4df791d9fb4bec0b4c62
Autor:
Rodrigo Entrialgo-Cadierno, Cristina Cueto-Ureña, Connor Welch, Iker Feliu, Irati Macaya, Laura Vera, Xabier Morales, Sandra Vietti Michelina, Pietro Scaparone, Ines Lopez, Elodie Darbo, Oihane Erice, Adrian Vallejo, Haritz Moreno, Ainhoa Goñi-Salaverri, David Lara-Astiaso, Nils Halberg, Ivan Cortes-Dominguez, Elizabeth Guruceaga, Chiara Ambrogio, Fernando Lecanda, Silve Vicent
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-23 (2023)
Abstract Background The discovery of functionally relevant KRAS effectors in lung and pancreatic ductal adenocarcinoma (LUAD and PDAC) may yield novel molecular targets or mechanisms amenable to inhibition strategies. Phospholipids availability has b
Externí odkaz:
https://doaj.org/article/4f6be978317d4dc0ae3c2a262e7964af
Autor:
David Repáraz, Marta Ruiz, Leyre Silva, Belén Aparicio, Josune Egea, Elizabeth Guruceaga, Daniel Ajona, Yaiza Senent, Enrique Conde, Flor Navarro, Sergio Barace, Diego Alignani, Sandra Hervás-Stubbs, Juan José Lasarte, Diana Llopiz, Pablo Sarobe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccination using optimized strategies may increase response rates to immune checkpoint inhibitors (ICI) in some tumors. To enhance vaccine potency and improve thus responses to ICI, we analyzed the gene expression profile of an immunosuppressive den
Externí odkaz:
https://doaj.org/article/53cc78736e214f2f9fa14856330d5191
Autor:
Rodrigo Entrialgo‑Cadierno, Cristina Cueto‑Ureña, Connor Welch, Iker Feliu, Irati Macaya, Laura Vera, Xabier Morales, Sandra Vietti Michelina, Pietro Scaparone, Ines Lopez, Elodie Darbo, Oihane Erice, Adrian Vallejo, Haritz Moreno, Ainhoa Goñi‑Salaverri, David Lara‑Astiaso, Nils Halberg, Ivan Cortes‑Dominguez, Elizabeth Guruceaga, Chiara Ambrogio, Fernando Lecanda, Silve Vicent
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/05018549b48a4e08a6c7bb8bdcca3266
Autor:
Esther Larrea, Celia Fernández-Rubio, José Peña-Guerrero, Elizabeth Guruceaga, Paul A. Nguewa
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13203 (2022)
Around 15% of cancer cases are attributable to infectious agents. Epidemiological studies suggest that an association between leishmaniasis and cancer does exist. Recently, the homologue of PES1 in Leishmania major (LmjPES) was described to be involv
Externí odkaz:
https://doaj.org/article/40528ad1acf74de18bf494551db27be5
Autor:
Álvaro Quintanal-Villalonga, Irene Ferrer, Elizabeth Guruceaga, Cristina Cirauqui, Ángela Marrugal, Laura Ojeda, Santiago García, Jon Zugazagoitia, Sandra Muñoz-Galván, Fernando Lopez-Rios, Luis Montuenga, Silvestre Vicent, Sonia Molina-Pinelo, Amancio Carnero, Luis Paz-Ares
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Background: Fibroblast growth factor receptor (FGFR)1 and FGFR4 have been associated with tumorigenesis in a variety of tumour types. As a therapeutic approach, their inhibition has been attempted in different types of malignancies, including lung ca
Externí odkaz:
https://doaj.org/article/71a55935cbac4ea3b38d6c84f83516a9
Identifying the Main Functional Pathways Associated with Cognitive Resilience to Alzheimer’s Disease
Autor:
Marta Pérez-González, Sara Badesso, Elena Lorenzo, Elizabeth Guruceaga, Alberto Pérez-Mediavilla, Ana García-Osta, Mar Cuadrado-Tejedor
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9120 (2021)
Understanding the mechanisms involved in cognitive resilience in Alzheimer’s disease (AD) represents a promising strategy to identify novel treatments for dementia in AD. Previous findings from our group revealed that the study of aged-Tg2576 cogni
Externí odkaz:
https://doaj.org/article/41e0469488634e54a4f5fe466fa6cac0
Publikováno v:
Toxins, Vol 13, Iss 3, p 177 (2021)
The mycotoxin ochratoxin A (OTA) is a potent nephrocarcinogen, mainly in male rats. The aim of this study was to determine the time course of gene expression (GeneChip® Rat Gene 2.0 ST Array, Affymetrix) in kidney samples from male and female F344 r
Externí odkaz:
https://doaj.org/article/2194a4ff3d5a467c94e7d22a597b96da