Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elizabeth G. Wills"'
Publikováno v:
Journal of Virology. 88:11121-11129
Previous reports showed that raltegravir, a recently approved antiviral compound that targets HIV integrase, can inhibit the nuclease function of human cytomegalovirus (HCMV terminase) in vitro . In this study, subtoxic levels of raltegravir were sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95a63f26d49609e87b37249f9f2bf4f
https://doi.org/10.1128/jvi.01540-14
https://doi.org/10.1128/jvi.01540-14
Publikováno v:
Journal of Virology. 87:6876-6887
Previous experiments identified a 12-amino-acid (aa) peptide that was sufficient to interact with the herpes simplex virus 1 (HSV-1) portal protein and was necessary to incorporate the portal into capsids. In the present study, cells were treated at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2953bf6977402733423add341f5cd42
https://doi.org/10.1128/jvi.00421-13
https://doi.org/10.1128/jvi.00421-13
Publikováno v:
Journal of Virology. 85:11972-11980
Herpesvirus genomic DNA is cleaved from concatemers that accumulate in infected cell nuclei. Genomic DNA is inserted into preassembled capsids through a unique portal vertex. Extensive analyses of viral mutants have indicated that intact capsids, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4859d45ea82fff1d2494f658433093
https://doi.org/10.1128/jvi.00857-11
https://doi.org/10.1128/jvi.00857-11
Publikováno v:
Journal of Virology. 83:5181-5191
Herpes simplex virus 1 nucleocapsids bud through the inner nuclear membrane (INM) into the perinuclear space to obtain a primary viral envelope. This process requires a protein complex at the INM composed of the U L 31 and U L 34 gene products. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85103d1e17cba81e4a14cb2718becedf
https://doi.org/10.1128/jvi.00090-09
https://doi.org/10.1128/jvi.00090-09
Publikováno v:
Journal of Virology. 83:4557-4564
Herpes simplex virus (HSV) type 1 capsids contain a single portal vertex that is composed of 12 copies of the U L 6 gene product (pU L 6), which forms a pore through which DNA is inserted during packaging. This unique vertex is also believed to compr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9952ac0ece70764c7082f677fb73fcb3
https://doi.org/10.1128/jvi.00026-09
https://doi.org/10.1128/jvi.00026-09
Publikováno v:
Journal of Virology. 82:8094-8104
Previous results indicated that the U L 34 protein (pU L 34) of herpes simplex virus 1 (HSV-1) is targeted to the nuclear membrane and is essential for nuclear egress of nucleocapsids. The normal localization of pU L 34 and virions requires the U S 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::143e266e9b30b384dad06cd05581ab63
https://doi.org/10.1128/jvi.00874-08
https://doi.org/10.1128/jvi.00874-08
Publikováno v:
Journal of Virology. 80:10894-10899
Studies to localize the herpes simplex virus 1 portal protein encoded by U L 6, the putative terminase components encoded by U L 15, U L 28, and U L 33, the minor capsid proteins encoded by U L 17, and the major scaffold protein ICP35 were conducted.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea0ac4d8e25288656d0fa3e90d836fca
https://doi.org/10.1128/jvi.01364-06
https://doi.org/10.1128/jvi.01364-06
Publikováno v:
Journal of Virology. 76:8939-8952
The wild-type U L 31, U L 34, and U S 3 proteins localized on nuclear membranes and perinuclear virions; the U S 3 protein was also on cytoplasmic membranes and extranuclear virions. The U L 31 and U L 34 proteins were not detected in extracellular v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81e0cc4637f720277bc416ac37b3ad4d
https://doi.org/10.1128/jvi.76.17.8939-8952.2002
https://doi.org/10.1128/jvi.76.17.8939-8952.2002
Publikováno v:
Journal of virology, vol 88, iss 7
pU L 34 and pU L 31 of herpes simplex virus (HSV) comprise the nuclear egress complex (NEC) and are required for budding at the inner nuclear membrane. pU L 31 also associates with capsids, suggesting it bridges the capsid and pU L 34 in the nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c570a7e06db55e8c691d5d0575e6042
https://europepmc.org/articles/PMC3993549/
https://europepmc.org/articles/PMC3993549/
Autor:
Susan M. Johnston, Joel D. Baines, Valerie Le Sage, Yasushi Kawaguchi, Jake D. Alter, Bruce W. Banfield, Masany Jung, Elizabeth G. Wills
Herpes simplex virus 2 (HSV-2) is an important human pathogen that is the major cause of genital herpes infections and a significant contributor to the epidemic spread of human immunodeficiency virus infections. The UL21 gene is conserved throughout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9c294834477cf1e8c10feabdb5e983
https://europepmc.org/articles/PMC3648149/
https://europepmc.org/articles/PMC3648149/