Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Elizabeth G. Canty"'
Autor:
Katie J. Lee, Lisa Rambault, George Bou-Gharios, Peter D. Clegg, Riaz Akhtar, Gabriela Czanner, Rob van ‘t Hof, Elizabeth G. Canty-Laird
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/85128b1290fb417e9c2ede93c46f1d2d
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-15 (2017)
Joint degeneration: linking animal and human disease Cartilage, and other tissues in our joints, begins to degenerate with age resulting in pain and reduced mobility; this is termed osteoarthritis (OA). To understand OA better researchers have often
Externí odkaz:
https://doaj.org/article/7cfff89113c548ac876d61f364504387
Autor:
Susan H Taylor, Ching-Yan Chloé Yeung, Nicholas S Kalson, Yinhui Lu, Paola Zigrino, Tobias Starborg, Stacey Warwood, David F Holmes, Elizabeth G Canty-Laird, Cornelia Mauch, Karl E Kadler
Publikováno v:
eLife, Vol 4 (2015)
Type I collagen-containing fibrils are major structural components of the extracellular matrix of vertebrate tissues, especially tendon, but how they are formed is not fully understood. MMP14 is a potent pericellular collagenase that can cleave type
Externí odkaz:
https://doaj.org/article/cdea2291326c4d7cb7c7cc63eaf460af
Autor:
Adam J Janvier, Emily G Pendleton, Luke J Mortensen, Daniel C Green, James R Henstock, Elizabeth G Canty-Laird
Publikováno v:
Journal of Tissue Engineering. 13:204173142211304
Tendon is predominantly composed of aligned type I collagen, but additional isoforms are known to influence fibril architecture and maturation, which contribute to the tendon’s overall biomechanical performance. The role of the less well-studied co
Autor:
Katie J, Lee, Eithne J, Comerford, Deborah M, Simpson, Peter D, Clegg, Elizabeth G, Canty-Laird
Publikováno v:
Journal of proteome research. 18(3)
Ligaments are prone to injury and degeneration in humans and animals, however the healing potential of ligament is poor and current treatment options ineffective. Stem cell-based therapies hold potential for treatment of ligament injuries. This study
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Publikováno v:
NPJ Systems Biology and Applications
Complexities in degenerative disorders, such as osteoarthritis, arise from multiscale biological, environmental, and temporal perturbations. Animal models serve to provide controlled representations of the natural history of degenerative disorders, b
Publikováno v:
Journal of Biological Chemistry. 283:12129-12135
It is established fact that type I collagen spontaneously self-assembles in vitro in the absence of cells or other macromolecules. Whether or not this is the situation in vivo was unknown. Recent evidence shows that intracellular cleavage of procolla
Autor:
Ching-Yan Chloé Yeung, Leo A. H. Zeef, Chloe Lallyett, Yinhui Lu, Elizabeth G. Canty-Laird, Karl E. Kadler
Publikováno v:
Scientific Reports
Collagen- and fibrin-based gels are extensively used to study cell behaviour. However, 2D-3D and collagen-fibrin comparisons of gene expression, cell shape and mechanotransduction, with an in vivo reference, have not been reported. Here we compared c
Autor:
David F. Holmes, Elizabeth G. Canty, Michael K. Shaw, Roger S. Meadows, Karl E. Kadler, Yinhui Lu
Publikováno v:
The Journal of Cell Biology
The functional properties of tendon require an extracellular matrix (ECM) rich in elongated collagen fibrils in parallel register. We sought to understand how embryonic fibroblasts elaborate this exquisite arrangement of fibrils. We show that procoll