Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Elizabeth G. Besteman"'
Autor:
Katerina, Vlasakova, Jennifer, Bourque, Wendy J, Bailey, Shetal, Patel, Elizabeth G, Besteman, Raymond J, Gonzalez, Frank D, Sistare, Warren E, Glaab
Publikováno v:
Toxicological Sciences. 187:219-233
The ability to monitor for general drug-induced tissue injury (DITI) or systemic inflammation in any tissue using blood-based accessible biomarkers would provide a valuable tool in early exploratory animal studies to understand potential drug liabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b063b32a14b4046a9ff7c68d7d3fd6a5
https://doi.org/10.1093/toxsci/kfac030
https://doi.org/10.1093/toxsci/kfac030
Autor:
Marjory B Brooks, James R Turk, Abraham Guerrero, Padma K Narayanan, John P Nolan, Elizabeth G Besteman, Dennis W Wilson, Roberta A Thomas, Cindy E Fishman, Karol L Thompson, Heidrun Ellinger-Ziegelbauer, Jennifer B Pierson, April Paulman, Alan Y Chiang, Albert E Schultze
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169976 (2017)
Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated intravascular coagulation (DIC). We studied an endotoxin-induced inflammatory state in rats
Externí odkaz:
https://doaj.org/article/d1a2148f4656495f9cebe693e28738c6
Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats
Autor:
Yi-Zhong Gu, Katerina Vlasakova, Glen Miller, Nicholas T. Gatto, Paul J. Ciaccio, Sabu Kuruvilla, Elizabeth G. Besteman, Roger Smith, Spencer J. Reynolds, Rupesh P. Amin, Warren E. Glaab, Gordon Wollenberg, Jose Lebron, Frank D. Sistare
Publikováno v:
Toxicologic Pathology. :019262332311628
Activating mutations of the leucine-rich repeat kinase 2 ( LRRK2) gene are associated with Parkinson disease (PD), prompting development of LRRK2 inhibitors as potential treatment for PD. However, kidney safety concerns have surfaced from LRRK2 knock
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca81b65118f034c663e621457909c3ff
https://doi.org/10.1177/01926233231162809
https://doi.org/10.1177/01926233231162809
Autor:
John P. Nolan, Jennifer B. Pierson, Marjory B. Brooks, James R. Turk, Cindy E. Fishman, Dennis W Wilson, Heidrun Ellinger-Ziegelbauer, Albert E. Schultze, April Paulman, Karol L. Thompson, Padma K. Narayanan, Abraham Guerrero, Elizabeth G. Besteman, Roberta A. Thomas, Alan Y. Chiang
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169976 (2017)
PLoS ONE
PLoS ONE
Systemic inflammation co-activates coagulation, which unchecked culminates in a lethal syndrome of multi-organ microvascular thrombosis known as disseminated intravascular coagulation (DIC). We studied an endotoxin-induced inflammatory state in rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f0f7b6e886f341ea0b64779bd07d26
http://europepmc.org/articles/PMC5233421?pdf=render
http://europepmc.org/articles/PMC5233421?pdf=render
Autor:
Kurt L. Zimmerman, Elizabeth G. Besteman, Steven D. Holladay, William R. Huckle, M. Renee Prater, Robert M. Gogal
Publikováno v:
Toxicologic Pathology. 35:786-792
TCDD and DES have immunotoxic effects, including selective diminution of T lymphocyte progenitors in the fetal liver. The histologic presentation of fetal liver after exposure to either chemical has not been described. Similarly, limited information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a16f1581399695af12e47611c1829990
https://doi.org/10.1080/01926230701584155
https://doi.org/10.1080/01926230701584155
Publikováno v:
International Journal of Toxicology. 24:231-239
Treatment of pregnant C57Bl/6 mice with 48 μg/kg diethylstilbestrol (DES) on gestation days (GDs) 14 and 16 resulted in both decreased day 18 fetal thymic cellularity as well as alterations in thymocyte phenotype. Histopathologic examination of GD 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37193ecfbf09a159861e328b81c74c69
https://doi.org/10.1080/10915810591000703
https://doi.org/10.1080/10915810591000703
Publikováno v:
Journal of immunotoxicology. 2(2)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes thymic atrophy as well as alterations in thymocyte maturity in mice. Multiple mechanisms for thymic hypocellularity have been suggested, and include an increase in thymocyte apoptosis, a maturation ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba86896c7b21a1ddfc30f236e4cad710
https://pubmed.ncbi.nlm.nih.gov/18958664
https://pubmed.ncbi.nlm.nih.gov/18958664