Výsledky vyhledávání - "Elizabeth G Sumiec"

Akademický článek

Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model

Autor: Zachary S Morris, Paul M Sondel, Amy K Erbe, Jacquelyn A Hank, Alexander L Rakhmilevich, Amber M Bates, Claire C Baniel, Elizabeth G Sumiec, Alexander A Pieper, Anna G Hoefges, Ravi B Patel

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background Some patients with cancer treated with anticancer monoclonal antibodies (mAbs) develop antidrug antibodies (ADAs) that recognize and bind the therapeutic antibody. This response may neutralize the therapeutic mAb, interfere with mAb effect

Externí odkaz: https://doaj.org/article/cc4227e91f4b49f0a30308d759d06c22

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Akademický článek

Estrogen receptor blockade and radiation therapy cooperate to enhance the response of immunologically cold ER+ breast cancer to immunotherapy

Autor: Kathleen A. O’Leary, Amber M. Bates, Won Jong Jin, Brian M. Burkel, Raghava N. Sriramaneni, Sarah E. Emma, Erin J. Nystuen, Elizabeth G. Sumiec, Suzanne M. Ponik, Zachary S. Morris, Linda A. Schuler

Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-15 (2023)

Abstract Background Most patients with estrogen receptor positive (ER+) breast cancer do not respond to immune checkpoint inhibition (ICI); the tumor microenvironment (TME) of these cancers is generally immunosuppressive and contains few tumor-infilt

Externí odkaz: https://doaj.org/article/ed62145c75cf435aa09efab35a43623c

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Akademický článek

In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response

Autor: Claire C. Baniel, Clinton M. Heinze, Anna Hoefges, Elizabeth G. Sumiec, Jaquelyn A. Hank, Peter M. Carlson, Won Jong Jin, Ravi B. Patel, Raghava N. Sriramaneni, Stephen D. Gillies, Amy K. Erbe, Ciara N. Schwarz, Alexander A. Pieper, Alexander L. Rakhmilevich, Paul M. Sondel, Zachary S. Morris

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

In a syngeneic murine melanoma (MEL) model, we recently reported an in situ vaccination response to combined radiation (RT) and intra-tumoral (IT) injection of anti-GD2 hu14. 18-IL2 immunocytokine (IC). This combined treatment resulted in 71% complet

Externí odkaz: https://doaj.org/article/69d352c38672413f9676b26e4741f6de

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Abstract 676: Fulvestrant and radiation modify the tumor immune microenvironment in ER+ metastatic breast cancer and cooperate to enhance response to anti-PDL1 checkpoint blockade

Autor: Sarah E. Emma, Elizabeth G. Sumiec, Zachary S. Morris, Erin J. Nystuen, Kathleen A. O'Leary, Linda A. Schuler, Amber M. Bates

Publikováno v: Cancer Research. 81:676-676

Metastatic, hormone therapy-resistant breast cancers expressing estrogen receptor (ER+) account for most breast cancer deaths. A lack of tumor-infiltrating lymphocytes (TILs) and low tumor mutation burden render most ER+ breast cancers immunologicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1214b591e76df2634aed22293c4b2c84
https://doi.org/10.1158/1538-7445.am2021-676

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Abstract 679: In vivo synergy of 90Y-NM600 and Bempegaldesleukin improves anti-tumor efficacy of immune checkpoint inhibitors in syngeneic murine cancer models

Autor: Justin C. Jagodinsky, Sarah E. Emma, Ravi B. Patel, Alexander A. Pieper, Joseph Grudzinski, Ian Marsh, Gustavo A. Sosa, Elizabeth G. Sumiec, Zachary S. Morris, Bryan P. Bednarz, Reinier Hernandez, Jamey Paul Weichert, Amber M. Bates, Erin J. Nystuen

Publikováno v: Cancer Research. 81:679-679

We have observed in preclinical studies that the delivery of low dose targeted radionuclide therapy (TRT) therapy to sites of primary and metastatic cancer can improve the anti-tumor immune response to immune checkpoint inhibition (ICI) with anti-CTL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::563fc7ed42398fd9a799813b729e686e
https://doi.org/10.1158/1538-7445.am2021-679

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Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model

Autor: Elizabeth G. Sumiec, Claire C. Baniel, Alexander A. Pieper, Paul M. Sondel, Anna Hoefges, Amy K. Erbe, Jacqueline A Hank, Zachary S. Morris, Ravi Patel, Alexander L. Rakhmilevich, Amber M. Bates

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

BackgroundSome patients with cancer treated with anticancer monoclonal antibodies (mAbs) develop antidrug antibodies (ADAs) that recognize and bind the therapeutic antibody. This response may neutralize the therapeutic mAb, interfere with mAb effecto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92481faab4e9caa6d6c2d6d89f4cf33d
https://doi.org/10.1136/jitc-2020-001262

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Abstract 902: Augmentation of anti-melanoma response by combining radiation-based in situ vaccination with GIFT4 B cell therapy

Autor: Claire C. Baniel, Zachary S. Morris, Paul M. Sondel, Jacques Galipeau, Erin J. Nystuen, Elizabeth G. Sumiec, Sarah E. Emma, Amy K. Erbe, Amber M. Bates, Pradyut K. Paul, Alexander L. Rakhmilevich

Publikováno v: Cancer Research. 80:902-902

We have recently demonstrated the effectiveness of combining external beam radiation therapy (RT), intratumoral immunocytokine (IT-IC), and anti-CTLA4 (αCTLA4) in eliminating large (500mm3) B78 melanomas (MEL), prolonging survival and invoking T cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce9c49c44e88b332412e743a0dd0c58b
https://doi.org/10.1158/1538-7445.am2020-902

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Abstract 2255: Enhancing immunogenicity in immunologically cold ER+ breast cancer using estrogen receptor blockade and radiation therapy

Autor: Erin J. Nystuen, Zachary S. Morris, Elizabeth G. Sumiec, Sarah E. Emma, Kathleen A. O'Leary, Linda A. Schuler, Amber M. Bates

Publikováno v: Cancer Research. 80:2255-2255

Metastatic, hormone therapy-resistant breast cancers expressing estrogen receptor (ER+) account for the majority of breast cancer deaths. ER+ breast cancers are immunologically “cold” with low tumor mutation burden and few tumor-infiltrating lymp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6ea3158aa0543b6988be8f506066e62
https://doi.org/10.1158/1538-7445.am2020-2255

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Abstract 903: In vivo efficacy of bempegaldesleukin, immune checkpoint inhibition, and targeted radionuclide therapy in immunocompetent murine model of head and neck cancer

Autor: Sarah E. Emma, Joseph Grudzinski, Zachary S. Morris, Jamey P. Weichert, Bryan Bednarz, Reinier Hernandez, Elizabeth G. Sumiec, Ian Marsh, Gustavo A. Sosa, Ravi Patel, Amber M. Bates, Alexander A. Pieper, Erin J. Nystuen

Publikováno v: Cancer Research. 80:903-903

In preclinical studies, we have demonstrated that delivering low dose radiation therapy to all sites of metastatic cancer using targeted radionuclide therapy (TRT) can improve the response to immune checkpoint blockade. NM600 is a tumor-targeting alk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3d50c4f6319bdfd172e43d58295cc58
https://doi.org/10.1158/1538-7445.am2020-903

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