Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elizabeth Fyne"'
Publikováno v:
Journal of Philosophy in Schools, Vol 11, Iss 1, Pp 63-82 (2024)
This paper addresses the question of how to educate toward democracy, which has as its defining trait the ability to self-correct. We draw on a study that investigated Deep Reflective Thinking (DRT) as a classroom method for cultivating collective do
Externí odkaz:
https://doaj.org/article/bb8b251b67634cf791ae6346f3f9aeec
Autor:
John K Bui, Joshua C Cyktor, Elizabeth Fyne, Shalyn Campellone, Stephen W Mason, John W Mellors
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211112 (2019)
Blockade of the programmed cell death protein/ligand 1 (PD-1/PD-L1) pathway with monoclonal antibodies (mAb) is now commonly used for cancer immunotherapy and has therapeutic potential in chronic viral infections including HIV-1. PD-1/PD-L1 blockade
Externí odkaz:
https://doaj.org/article/b9add7607f004936b20e9a70dcc506ad
Autor:
John K Bui, Elias K Halvas, Elizabeth Fyne, Michele D Sobolewski, Dianna Koontz, Wei Shao, Brian Luke, Feiyu F Hong, Mary F Kearney, John W Mellors
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006230 (2017)
The fate of HIV-infected cells after reversal of proviral latency is not well characterized. Simonetti, et al. recently showed that CD4+ T-cells containing intact proviruses can clonally expand in vivo and produce low-level infectious viremia. We hyp
Externí odkaz:
https://doaj.org/article/ee331779609b446789aaefe54e5f381a
Autor:
Datsen George Wei, Vicki Chiang, Elizabeth Fyne, Mini Balakrishnan, Tiffany Barnes, Michael Graupe, Joseph Hesselgesser, Alivelu Irrinki, Jeffrey P Murry, George Stepan, Kirsten M Stray, Angela Tsai, Helen Yu, Jonathan Spindler, Mary Kearney, Celsa A Spina, Deborah McMahon, Jacob Lalezari, Derek Sloan, John Mellors, Romas Geleziunas, Tomas Cihlar
Publikováno v:
PLoS Pathogens, Vol 10, Iss 4, p e1004071 (2014)
Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a major obstacle to curing HIV infection. Pharmacological activation of HIV expression in latently infected cells is being explored as one of the strategies to d
Externí odkaz:
https://doaj.org/article/ac65303f63b846a6ab208ba464922569
Autor:
Evgenia Aga, Aarika L. Yates, Cheryl Jennings, John W. Mellors, Anthony R. Cillo, Dianna Koontz, Guillaume Besson, Elizabeth Fyne, Lu Zheng, Feiyu Hong
Publikováno v:
Journal of Clinical Microbiology. 54:902-911
Although a number of PCR-based quantitative assays for measuring HIV-1 persistence during suppressive antiretroviral therapy (ART) have been reported, a simple, sensitive, reproducible method is needed for application to large clinical trials. We dev
Autor:
Elias K. Halvas, Jonathan Spindler, John W. Mellors, Catherine Rehm, Michael Piatak, Sarah A. Watters, Michael A. Polis, Mary F. Kearney, Francesco R. Simonetti, Stephen H. Hughes, Thomas S. Uldrick, Elizabeth Fyne, Joseph A. Kovacs, Frank Maldarelli, Junko Hattori, John M. Coffin, Kerri J. Penrose, Brandon F. Keele, Guillaume Besson, Wei Shao, Robert J. Gorelick, Li Su, David Wells, Michele D. Sobolewski, Shawn Hill, Richard Kwan, Deborah Citrin, Zhiming Yang, Brian T. Luke, Elizabeth M. Anderson, Xiaolin Wu, Carter Van Waes
Publikováno v:
Proceedings of the National Academy of Sciences. 113:1883-1888
Significance Reservoirs of HIV-infected cells persist during antiretroviral therapy, and understanding persistence is essential to develop HIV curative strategies. During replication, HIV integrates into the host genome; most proviruses are not infec
Autor:
John K. Bui, Shalyn Campellone, Joshua C. Cyktor, Stephen W. Mason, John W. Mellors, Elizabeth Fyne
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0211112 (2019)
PLoS ONE, Vol 14, Iss 1, p e0211112 (2019)
Blockade of the programmed cell death protein/ligand 1 (PD-1/PD-L1) pathway with monoclonal antibodies (mAb) is now commonly used for cancer immunotherapy and has therapeutic potential in chronic viral infections including HIV-1. PD-1/PD-L1 blockade
Autor:
Dianna Koontz, Elizabeth Fyne, Evgenia Aga, Jana L. Jacobs, John W. Mellors, Feiyu Hong, Anthony R. Cillo, Lu Zheng
Publikováno v:
Virology. 521
The relationships between HIV-1 DNA copy number, proviral transcriptional activity, and residual plasma viremia in individuals off and on ART are not well defined. To address this, we performed a cross-sectional study of 12 viremic donors and 23 ART-
Autor:
Michael Piatak, John W. Mellors, Elizabeth Fyne, Dianna Koontz, Anthony R. Cillo, John M. Coffin, Mary F. Kearney, Margaret A. Bedison, David Vagratian, Elizabeth M. Anderson
Publikováno v:
Journal of Clinical Microbiology. 52:3944-3951
A quantitative real-time PCR (qRT-PCR) assay with single-copy sensitivity targeting HIV-1 gag RNA (the gag single-copy assay [gSCA]) has been used widely to quantify plasma viremia below the limit of detection of clinical assays in patients on effect
Autor:
Kelly Huber, Geneviève Doyon, Joseph Plaks, Elizabeth Fyne, John W. Mellors, Nicolas Sluis-Cremer
Publikováno v:
Journal of Biological Chemistry. 286:22211-22218
Disclosed are compounds which inhibit histone deacetylase (HDAC) enzymatic activity. Also disclosed are pharmaceutical compositions comprising such compounds as well as methods to treat conditions, particularly proliferative conditions, mediated at l