Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Elizabeth Fidalgo da Silva"'
Publikováno v:
PLoS ONE, Vol 17, Iss 8, p e0272741 (2022)
Tuberin is a major component of the protein regulatory complex known as the Tuberous Sclerosis Complex and plays a crucial role in cell cycle progression and protein synthesis. Mutations in the Tuberin gene, TSC2, lead to the formation of benign tumo
Externí odkaz:
https://doaj.org/article/093045e65882486287dd239e683b5d9d
Autor:
Elizabeth Fidalgo da Silva, Sabrina Botsford, Jessica Dare-Shih, Miranda A Hanna, Lisa A Porter
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210612 (2019)
A great deal of ground breaking work has determined that the Tuberin and Hamartin Complex function as a negative regulator of protein synthesis and cell cycle progression through G1/S. This is largely attributed to the GTPase activity of Tuberin that
Externí odkaz:
https://doaj.org/article/38489f3b751641e0bd84b2428deae78d
Autor:
Elizabeth Fidalgo da Silva, Bashaer Abu Khatir, Christopher Drouillard, Isabelle Hinch, Gordon Omar Davis, Mariam Sameem, Rutu Patel, Jackie Fong, Dorota Lubanska, Lisa A. Porter
Publikováno v:
Differentiation; research in biological diversity. 130
Tuberin is a member of a large protein complex, Tuberous Sclerosis Complex (TSC), and acts as a sensor for nutrient status regulating protein synthesis and cell cycle progression. Mutations in the Tuberin gene, TSC2, permits the formation of tumors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499eb40ff1dc25c78af8a6205b4ac50d
https://pubmed.ncbi.nlm.nih.gov/36608575
https://pubmed.ncbi.nlm.nih.gov/36608575
Autor:
Elizabeth Fidalgo da Silva, Megan Byrne, Lisa A. Porter, Dorota Lubanska, Kaitlyn N Matthews, Jillian Brown, Bre-Anne Fifield, Ingrid Qemo
Publikováno v:
Stem cells (Dayton, Ohio)REFERENCES. 39(12)
Fully differentiated cells can be reprogrammed through ectopic expression of key transcription factors to create induced pluripotent stem cells. These cells share many characteristics of normal embryonic stem cells and have great promise in disease m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34314892a520719bbe23b751552402e
https://pubmed.ncbi.nlm.nih.gov/34486784
https://pubmed.ncbi.nlm.nih.gov/34486784
Autor:
Lisa A. Porter, Elizabeth Fidalgo da Silva, Ana C. deCarvalho, Brenna A. Market-Velker, Dorota Lubanska, Tom Mikkelsen
Publikováno v:
Biological Sciences Publications
Summary The heterogeneity of brain cancers, as most solid tumors, complicates diagnosis and treatment. Identifying and targeting populations of cells driving tumorigenesis is a top priority for the cancer biology field. This is not a trivial task; co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2bd3294511725a4d91ba14751f3a33
https://doi.org/10.1016/j.ccr.2013.12.006
https://doi.org/10.1016/j.ccr.2013.12.006
Autor:
Jessica Morgan Dare-Shih, Elizabeth Fidalgo da Silva, Miranda A. Hanna, Lisa A. Porter, Sabrina Botsford
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 1, p e0210612 (2019)
PLoS ONE, Vol 14, Iss 1, p e0210612 (2019)
A great deal of ground breaking work has determined that the Tuberin and Hamartin Complex function as a negative regulator of protein synthesis and cell cycle progression through G1/S. This is largely attributed to the GTPase activity of Tuberin that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbbc086115a39519e5c713551443a2a0
https://doi.org/10.1371/journal.pone.0210612
https://doi.org/10.1371/journal.pone.0210612
Publikováno v:
Nucleic Acids Research
DNA polymerases achieve high-fidelity DNA replication in part by checking the accuracy of each nucleotide that is incorporated and, if a mistake is made, the incorrect nucleotide is removed before further primer extension takes place. In order to pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd941881e5bc9ebfc306cd9424ccb05
https://doi.org/10.1093/nar/gkm591
https://doi.org/10.1093/nar/gkm591
Autor:
Kerry N. McPhedran, Elizabeth Fidalgo da Silva, Michael James Reaume, Lisa A. Porter, Rajesh Seth
Publikováno v:
Biological Sciences Publications
Ozone has been shown to be effective in the transformation of several chemicals of emerging concern that escape the wastewater treatment process, but there is concern whether toxic transformation products are formed. Two parallel biofilter columns wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00646e164cd0915e3565a1af4d2c5463
https://scholar.uwindsor.ca/context/biologypub/article/1777/viewcontent/Reaume_et_al.___2015___Effect_of_Media_on_Biofilter_Performance_Following.pdf
https://scholar.uwindsor.ca/context/biologypub/article/1777/viewcontent/Reaume_et_al.___2015___Effect_of_Media_on_Biofilter_Performance_Following.pdf
Autor:
Kelly Murphy, Elizabeth Fidalgo da Silva, Amy Schultz, Linda J. Reha-Krantz, Hariyanto Darmawan
Publikováno v:
Genome. 49:403-410
Proofreading DNA polymerases share common short peptide motifs that bind Mg2+in the exonuclease active center; however, hydrolysis rates are not the same for all of the enzymes, which indicates that there are functional and likely structural differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a948771883a84d9d147b45f1a225321
https://doi.org/10.1139/g05-106
https://doi.org/10.1139/g05-106
Autor:
Hector Barrabin, Helena M. Scofano, Joyce R. Pearlstone, Monica M. Freire, Elizabeth Fidalgo da Silva, J. David Johnson, Svetlana B. Tikunova, Murali Chandra, Martha M. Sorenson
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 38:209-221
Calmodulin (CaM) and troponin C (TnC) are EF-hand proteins that play fundamentally different roles in animal physiology. TnC has a very low affinity for the plasma membrane Ca2+-ATPase and is a poor substitute for CaM in increasing the enzyme's affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c7c4f8e36f8c978c44d6df50e020704
https://doi.org/10.1016/j.biocel.2005.08.016
https://doi.org/10.1016/j.biocel.2005.08.016