Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elizabeth Farrant"'
Autor:
Christopher N. Selway, Bimbisar Desai, Adrian G. Wright, Gary J. Tarver, Werngard Czechtizky, Karen Dixon, Qixing Feng, Manoj K. Ramjee, David M. Parry, Juergen Dedio, Elizabeth Farrant, Thorsten Schmidt, Trevor Morgan
Publikováno v:
ACS Medicinal Chemistry Letters. 4:768-772
A novel integrated discovery platform has been used to synthesize and biologically assay a series of xanthine-derived dipeptidyl peptidase 4 (DPP4) antagonists. Design, synthesis, purification, quantitation, dilution, and bioassay have all been fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bace8132944a627147abd3e1a0919fb8
https://doi.org/10.1021/ml400171b
https://doi.org/10.1021/ml400171b
Publikováno v:
Organic Process Research & Development. 12:1007-1011
Microwave-assisted organic synthesis in a laboratory-scale monomodal microwave reactor is investigated for continuous flow applications using fluorous spacer technology. The benchtop continuous flow microwave described allows sequential processing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88276e57c1e7312e3f04697c4baf804c
https://doi.org/10.1021/op700225u
https://doi.org/10.1021/op700225u
Autor:
Martyn Deal, Brian H. Warrington, Simon J. F. Macdonald, Otman Benali, Elizabeth Farrant, Rob C. Wheeler
Publikováno v:
Organic Process Research & Development. 11:704-710
In recent years, chemistry in flowing systems has become more prominent as a method of carrying out chemical transformations, ranging in scale from analytical-scale (microchemistry) through to kilogram-scale synthesis (macrochemistry). The advantages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::650574a66e74ed7eff6aee3144c0063e
https://doi.org/10.1021/op7000707
https://doi.org/10.1021/op7000707
Publikováno v:
Tetrahedron Letters. 41:5383-5386
A novel route for the solid-phase synthesis of 1,2,5-substituted 7-azabenzimidazole derivatives has been developed. Primary amines are attached to an aldehyde resin then coupled to 6-chloro-5-nitro-nicotinyl chloride. Subsequent alkylation with amine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01f3364dbae67fd19834e4b3e9754cd5
https://doi.org/10.1016/s0040-4039(00)00859-5
https://doi.org/10.1016/s0040-4039(00)00859-5
Autor:
Gary J. Tarver, Adrian G. Wright, Trevor Morgan, Qixing Feng, Elizabeth Farrant, Manoj K. Ramjee, Karen Dixon, David M. Parry, Christopher N. Selway, Willem P. van Hoorn, Bimbisar Desai, Gavin A. Whitlock, Karl Richard Gibson, James Edward John Mills
Publikováno v:
Journal of medicinal chemistry. 56(7)
Drug discovery faces economic and scientific imperatives to deliver lead molecules rapidly and efficiently. Using traditional paradigms the molecular design, synthesis, and screening loops enforce a significant time delay leading to inefficient use o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37c1c3b131c69733dd8ddcd1ae9f984
https://pubmed.ncbi.nlm.nih.gov/23441572
https://pubmed.ncbi.nlm.nih.gov/23441572
Autor:
Elizabeth Farrant
The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. I
Autor:
Elizabeth Farrant, Torren M. Peakman, Manuel Perez, Mark E. Bunnage, M. Abid Masood, Inaki Morao, Marc Bazin, Sally-Ann Fancy
Publikováno v:
ChemInform. 43
Mifepristone (I) and antalarmin (V) are used as substrates for the diversification of drug molecules using plate-based chemical screens.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eebe748ba40f90f02c178f0461034a1
https://doi.org/10.1002/chin.201221205
https://doi.org/10.1002/chin.201221205
Autor:
Elizabeth Farrant
Publikováno v:
New Synthetic Technologies in Medicinal Chemistry
The modern synthetic chemist applies all the tools available to identify the drug-like molecules with the best chances of becoming novel drugs. This book will act as a primer for graduates and postgraduates interested in a career in drug discovery. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da74d7ca3a405ed097d9e06db0f827ee
https://doi.org/10.1039/9781849733052
https://doi.org/10.1039/9781849733052
Autor:
Manuel Perez, Mark E. Bunnage, Elizabeth Farrant, Sally-Ann Fancy, Inaki Morao, Torren M. Peakman, Marc Bazin, M. Abid Masood
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
A series of C-H functionalisation plate-based chemical screens and other C-H activation protocols were developed for the chemical diversification of drug molecules. In this Letter, metalloporphyrin and other catalytic oxidation systems are described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a501b2392e4f65fde8407abf88e4a3b
https://pubmed.ncbi.nlm.nih.gov/22104142
https://pubmed.ncbi.nlm.nih.gov/22104142
Autor:
J. John Mann, Elizabeth Farrant
Publikováno v:
ChemInform. 28
A stereocontrolled synthesis of the indolizidine alkaloid skeleton has been achieved via an intramolecular, photoinduced reaction of (5S)-5-triisopropylsilyloxymethyl-3-{2′ -[(3″S)-3″ -methoxypyrrolidinyl]ethyl}furan-2-(5H)-one, which can be ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e74dd0af065f66346888a6fb60faf52
https://doi.org/10.1002/chin.199736248
https://doi.org/10.1002/chin.199736248