Zobrazeno 1 - 5 of 5 pro vyhledávání: '"Elizabeth F. King"'
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Akademický článek
Photo-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues.
Autor: Lindsay B Tulloch, Stefanie K Menzies, Andrew L Fraser, Eoin R Gould, Elizabeth F King, Marija K Zacharova, Gordon J Florence, Terry K Smith
Publikováno v: PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005886 (2017)
Current drugs to treat African sleeping sickness are inadequate and new therapies are urgently required. As part of a medicinal chemistry programme based upon the simplification of acetogenin-type ether scaffolds, we previously reported the promising
Externí odkaz: https://doaj.org/article/d7cf23932e2a4bed826d40db10641a11
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The acetogenic-based bis-tetrahydropyran 1,4-triazole, JM425 potentially targets the trypanosomatid mitochondrial complex V
Autor: Lindsay Tulloch, Stefanie K. Menzies, Andrew L. Fraser, Eoin R. Gould, Joanne C. Morris, Elizabeth F. King, Marija K. Zacharova, Terry K. Smith, Gordon J. Florence
The acetogenin family of polyketides produced by annonaceacous plants has broad anti-microbial activity through its potent inhibition of mitochondrial complex I. We recently reported [Florence, Chem. Med. Chem. 9;2548 (2014)] the trypanocidal activit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d20461751f281adbe0ddc804d06d78ac
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4
A mathematical model of biodegradability screening tests as an aid to interpretation of observed results
Autor: Elizabeth F. King, H.A. Painter
Publikováno v: Regulatory Toxicology and Pharmacology. 3:144-151
A mathematical model, based on a modification of the Michaelis-Menten and Monod equations describing bacterial growth, has been used to predict the course of removal of the organic substrates in the modified OECD and other screening tests. A range of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe50304e2838a2a63f2ee7d0ea2f6aa6
https://doi.org/10.1016/0273-2300(83)90039-9
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