M1-derived extracellular vesicles polarize recipient macrophages into M2-like macrophages and alter skeletal muscle homeostasis in a hyper-glucose environment

Autor: Stefano Tacconi, Francesco Vari, Carolina Sbarigia, Diana Vardanyan, Serena Longo, Francesco Mura, Federica Angilè, Audrey Jalabert, Ferninand Blangero, Assia Eljaafari, Laurence Canaple, Daniele Vergara, Francesco Paolo Fanizzi, Marco Rossi, Claire Crola Da Silva, Elizabeth Errazuriz-Cerda, Christel Cassin, Rienk Nieuwland, Anna Maria Giudetti, Sophie Rome, Luciana Dini

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)

Abstract Background Macrophages release not only cytokines but also extracellular vesicles (EVs). which are small membrane-derived nanovesicles with virus-like properties transferring cellular material between cells. Until now, the consequences of ma

Externí odkaz: https://doaj.org/article/a6d06157c0a94ebaa82b1e7dbc359089

Profiling of ob/ob mice skeletal muscle exosome-like vesicles demonstrates combined action of miRNAs, proteins and lipids to modulate lipid homeostasis in recipient cells

Autor: Sophie Rome, Myriam Aouadi, Karim Bouzakri, Laura Reininger, Emmanuelle Berger, Emmanuelle Meugnier, Alexis Forterre, Alain Géloën, Jennifer Rieusset, Elizabeth Errazuriz-Cerda, Yohann Couté, Audrey Jalabert

Publikováno v: Scientific Reports
Scientific Reports, 2021, 11 (1), ⟨10.1038/s41598-021-00983-3⟩
Scientific Reports, Nature Publishing Group, 2021, 11 (1), ⟨10.1038/s41598-021-00983-3⟩
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

We have determined the lipid, protein and miRNA composition of skeletal muscle (SkM)-released extracellular vesicles (ELVs) from Ob/ob (OB) vs wild-type (WT) mice. The results showed that atrophic insulin-resistant OB-SkM released less ELVs than WT-S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f99c0eea15381082febd458b4cb8462
https://hal.science/hal-03420029/document