Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Elizabeth Ensink"'
Autor:
Juozas Gordevicius, Peipei Li, Lee L. Marshall, Bryan A. Killinger, Sean Lang, Elizabeth Ensink, Nathan C. Kuhn, Wei Cui, Nazia Maroof, Roberta Lauria, Christina Rueb, Juliane Siebourg-Polster, Pierre Maliver, Jared Lamp, Irving Vega, Fredric P. Manfredsson, Markus Britschgi, Viviane Labrie
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Dysfunction of the gastrointestinal system, and to the autophagy lysososmal pathway (ALP) have been reported in Parkinson’s disease. Here the authors report epigenetic disruption of ALP related genes in the appendix of individuals with Parkinson’
Externí odkaz:
https://doaj.org/article/f9f6d09087434442861f49df6420270e
Autor:
Peipei Li, Elizabeth Ensink, Sean Lang, Lee Marshall, Meghan Schilthuis, Jared Lamp, Irving Vega, Viviane Labrie
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-23 (2020)
Abstract Background Hemispheric asymmetry in neuronal processes is a fundamental feature of the human brain and drives symptom lateralization in Parkinson’s disease (PD), but its molecular determinants are unknown. Here, we identify divergent epige
Externí odkaz:
https://doaj.org/article/09bfdfda0fb848b6983376e99e49cea9
Autor:
Peipei Li, Bryan A. Killinger, Elizabeth Ensink, Ian Beddows, Ali Yilmaz, Noah Lubben, Jared Lamp, Meghan Schilthuis, Irving E. Vega, Randy Woltjer, J. Andrew Pospisilik, Patrik Brundin, Lena Brundin, Stewart F. Graham, Viviane Labrie
Publikováno v:
Metabolites, Vol 11, Iss 1, p 29 (2021)
The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD). The vermiform appendix is a lymphoid tissue in the cecum implicated in the storage and regulation of the gut microbiota. We sought to determine whether the appen
Externí odkaz:
https://doaj.org/article/b60cac34011e44b08f4a9fdd5f33b059
Autor:
Markus Britschgi, Viviane Labrie, Irving E. Vega, Lee Marshall, Nazia Maroof, Juliane Siebourg-Polster, Nathan C. Kuhn, Peipei Li, Wei Cui, Juozas Gordevičius, Jared Lamp, Sean Lang, Fredric P. Manfredsson, Roberta Lauria, Christina Rueb, Elizabeth Ensink, Bryan A. Killinger, Pierre Maliver
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature communications, Berlin : Nature research, 2021, vol. 12, iss. 1, art. no. 5134, p. [1-18]
Nature Communications
Nature communications, Berlin : Nature research, 2021, vol. 12, iss. 1, art. no. 5134, p. [1-18]
The gastrointestinal tract may be a site of origin for α-synuclein pathology in idiopathic Parkinson’s disease (PD). Disruption of the autophagy-lysosome pathway (ALP) may contribute to α-synuclein aggregation. Here we examined epigenetic alterat
Autor:
Aoji Xie, Elizabeth Ensink, Peipei Li, Juozas Gordevičius, Lee L. Marshall, Sonia George, John Andrew Pospisilik, Velma T.E. Aho, Madelyn C. Houser, Pedro A.B. Pereira, Knut Rudi, Lars Paulin, Malú G. Tansey, Petri Auvinen, Patrik Brundin, Lena Brundin, Viviane Labrie, Filip Scheperjans
Background The gut microbiome and its metabolites can impact brain health and are altered in Parkinson's disease (PD) patients. It has been recently demonstrated that PD patients have reduced fecal levels of the potent epigenetic modulator butyrate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c898ac3e71214da9bb34cf27ae2f59
http://hdl.handle.net/10138/352161
http://hdl.handle.net/10138/352161
Autor:
Xinhe Wang, Bryan A. Killinger, Juozas Gordevičius, Stefan Jovinge, Elizabeth Ensink, Katie X. Li, Lee Marshall, Jiyan Ma, Peipei Li, Viviane Labrie, Gerhard A. Coetzee, Noah Lubben, Matthew Weiland, Wei Cui
Publikováno v:
Nature Neuroscience. 23:1203-1214
Parkinson's disease (PD) pathogenesis may involve the epigenetic control of enhancers that modify neuronal functions. Here, we comprehensively examine DNA methylation at enhancers, genome-wide, in neurons of patients with PD and of control individual
Autor:
Juozas Gordevičius, Malú G. Tansey, Sonia George, Pedro A. B. Pereira, Patrik Brundin, Knut Rudi, Viviane Labrie, Lee Marshall, Petri Auvinen, Lena Brundin, Madelyn C. Houser, J. Andrew Pospisilik, Elizabeth Ensink, Velma T. E. Aho, Peipei Li, Lars Paulin, Filip Scheperjans, Aoji Xie
BackgroundThe gut microbiome and its metabolites can impact brain health and are altered in Parkinson’s disease (PD) patients. It has been recently demonstrated that PD patients have reduced fecal levels of the potent epigenetic modulator butyrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b74f080bc525fb622418f5712097c1
https://doi.org/10.1101/2021.09.17.21263343
https://doi.org/10.1101/2021.09.17.21263343
Publikováno v:
Brain Communications
The lateralization of the human brain may provide clues into the pathogenesis and progression of neurodegenerative diseases. Though differing in their presentation and underlying pathologies, neurodegenerative diseases are all devastating and share a
Autor:
Stewart F. Graham, Meghan Schilthuis, Noah Lubben, Randy Woltjer, Viviane Labrie, Patrik Brundin, Peipei Li, Jared Lamp, Elizabeth Ensink, Lena Brundin, Bryan A. Killinger, Irving E. Vega, Ali Yilmaz, J. Andrew Pospisilik, Ian Beddows
Publikováno v:
Metabolites; Volume 11; Issue 1; Pages: 29
Metabolites
Metabolites, Vol 11, Iss 29, p 29 (2021)
Metabolites
Metabolites, Vol 11, Iss 29, p 29 (2021)
The gut microbiome can impact brain health and is altered in Parkinson’s disease (PD). The vermiform appendix is a lymphoid tissue in the cecum implicated in the storage and regulation of the gut microbiota. We sought to determine whether the appen
Autor:
Meghan Schilthuis, Noah Lubben, Patrik Brundin, Bryan A. Killinger, Peipei Li, Elizabeth Ensink, Jared Lamp, Ian Beddows, Lena Brundin, Viviane Labrie, J. Andrew Pospisilik, Irving E. Vega, Ali Yilmaz, Markus Britschgi, Stewart F. Graham
Objective: Parkinsons disease (PD) pathogenesis may involve the gastrointestinal tract, with recent evidence implicating the human vermiform appendix. The appendix is a lymphoid tissue involved in the storage and regulation of the gut microbiome. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23479d62988608d356c28daab4cfe219
https://doi.org/10.1101/2020.09.26.279851
https://doi.org/10.1101/2020.09.26.279851