Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Elizabeth E. Steinberg"'
Autor:
Neir Eshel, Elizabeth E Steinberg
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e3000043 (2018)
Most decisions share a common goal: maximize reward and minimize punishment. Achieving this goal requires learning which choices are likely to lead to favorable outcomes. Dopamine is essential for this process, enabling learning by signaling the diff
Externí odkaz:
https://doaj.org/article/748f0bef84494cd18d49566e85395ad9
Autor:
Elizabeth E Steinberg, Josiah R Boivin, Benjamin T Saunders, Ilana B Witten, Karl Deisseroth, Patricia H Janak
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94771 (2014)
The neural basis of positive reinforcement is often studied in the laboratory using intracranial self-stimulation (ICSS), a simple behavioral model in which subjects perform an action in order to obtain exogenous stimulation of a specific brain area.
Externí odkaz:
https://doaj.org/article/a61bc5148f6f4f6fbb1c1b206228a0eb
Autor:
Elizabeth E. Steinberg, Boris D. Heifets, Paul Hoerbelt, Madison D. Taylor, Robert C. Malenka, Daniel F. Cardozo Pinto, Ji Y. Sze, Juliana S. Salgado, Jessica J. Walsh
The extensively abused recreational drug (±)3,4-methylenedioxymethamphetamine (MDMA) has shown promise as an adjunct to psychotherapy for treatment-resistant psychiatric disease. It is unknown, however, whether the mechanisms underlying its prosocia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aba0ef51dac7159beca43728e519ee1
https://doi.org/10.1101/659466
https://doi.org/10.1101/659466
Autor:
Kevin T. Beier, Talia N. Lerner, Zane C. Norville, Karl Deisseroth, Felicity Gore, Robert C. Malenka, Madison D. Taylor, Liqun Luo, Elizabeth E. Steinberg, Boris D. Heifets, Csaba Földy
Publikováno v:
Neuron. 106:1026-1043.e9
The central amygdala (CeA) orchestrates adaptive responses to emotional events. While CeA substrates for defensive behaviors have been studied extensively, CeA circuits for appetitive behaviors and their relationship to threat-responsive circuits rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fbcaa79517b8c6b150df2bb4806749
https://doi.org/10.1016/j.neuron.2020.03.016
https://doi.org/10.1016/j.neuron.2020.03.016
Autor:
Neir Eshel, Elizabeth E. Steinberg
Publikováno v:
PLoS Biology
PLoS Biology, Vol 16, Iss 10, p e3000043 (2018)
PLoS Biology, Vol 16, Iss 10, p e3000043 (2018)
Recent computational models of sign tracking (ST) and goal tracking (GT) have accounted for observations that dopamine (DA) is not necessary for all forms of learning and have provided a set of predictions to further their validity. Among these, a ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a5c8e6ea284b2d257881f49e844590
https://pubmed.ncbi.nlm.nih.gov/30256785
https://pubmed.ncbi.nlm.nih.gov/30256785
Autor:
Marie Carlén, Karl Deisseroth, Hoseok Kim, Sofie Ährlund-Richter, Sheena A. Josselyn, Andre Berndt, Soo Yeun Lee, Robert C. Malenka, Scott L. Delp, Paul W. Frankland, Asim J. Rashid, Elizabeth E. Steinberg, Sungmo Park, Charu Ramakrishnan, Peter Hegemann, Adam Santoro, Sally Pak, Shrivats Mohan Iyer, Jonas Wietek
Publikováno v:
Proceedings of the National Academy of Sciences. 113:822-829
The structure-guided design of chloride-conducting channelrhodopsins has illuminated mechanisms underlying ion selectivity of this remarkable family of light-activated ion channels. The first generation of chloride-conducting channelrhodopsins, guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55899193e5159f3c765995614430e0ba
https://doi.org/10.1073/pnas.1523341113
https://doi.org/10.1073/pnas.1523341113
Autor:
Elizabeth E. Steinberg, Eric J. Kremer, Lindsay A. Schwarz, Katherine E. DeLoach, Xiaojing J. Gao, Liqun Luo, Kazunari Miyamichi, Kevin T. Beier, Stanley Xie, Robert C. Malenka
Publikováno v:
Cell
Cell, Elsevier, 2015, 162 (3), pp.622--34. ⟨10.1016/j.cell.2015.07.015⟩
Cell, Elsevier, 2015, 162 (3), pp.622--34. ⟨10.1016/j.cell.2015.07.015⟩
SummaryDopamine (DA) neurons in the midbrain ventral tegmental area (VTA) integrate complex inputs to encode multiple signals that influence motivated behaviors via diverse projections. Here, we combine axon-initiated viral transduction with rabies-m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93c61fc195273d1fd2ad580ac9b8dfc8
Autor:
Soo Yeun Lee, Garret D. Stuber, Thomas J. Davidson, Elizabeth E. Steinberg, Patricia H. Janak, Saemi L. Cho, Ilana B. Witten, Karl Deisseroth, Matthew Brodsky, Charu Ramakrishnan, Shiaoching Gong, Kay M. Tye, Kelly A. Zalocusky, Ofer Yizhar
Publikováno v:
Neuron. 72(5):721-733
Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous established neurophysiological and behavioral paradigms. To overcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53124ddef2ee43de1be21032f768c3d4
The brain’s remarkable capacity to generate cognition and behavior is mediated by an extraordinarily complex set of neural interactions that remain largely mysterious. This complexity poses a significant challenge in developing therapeutic interven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8943ab828b80b2c21f7fd90a7e9a7441
https://europepmc.org/articles/PMC4293223/
https://europepmc.org/articles/PMC4293223/
Autor:
Karl Deisseroth, Elizabeth E. Steinberg, Ronald Keiflin, Patricia H. Janak, Ilana B. Witten, Josiah R. Boivin
Publikováno v:
Nature neuroscience
Situations in which rewards are unexpectedly obtained or withheld represent opportunities for new learning. Often, this learning includes identifying cues that predict reward availability. Unexpected rewards strongly activate midbrain dopamine neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::326cf803a307f5aee48b70b59c096519
https://pubmed.ncbi.nlm.nih.gov/23799468
https://pubmed.ncbi.nlm.nih.gov/23799468