Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Elizabeth E. Eynon"'
Autor:
Till Strowig, Richard A. Flavell, Toma Tebaldi, Jonathan Alderman, Jie Chen, Yuanbin Song, Giulia Biancon, Rana Gbyli, Stephanie Halene, Xiaoying Fu, Yimeng Gao, Mina L. Xu, Diane S. Krause, Liang Shan, Wei Liu, Xiaman Wang, Padmavathi Mamillapalli, Amisha Patel, Elizabeth E. Eynon, Ashley Qin, David Urbonas, Emanuela M. Bruscia, David Gonzalez
Publikováno v:
Science
A red-letter day for RBC research The study of primary human red blood cell (huRBC) disorders such as sickle cell disease (SCD) and infectious diseases such as malaria has been hampered by a lack of in vivo models of human erythropoiesis. Song et al.
Autor:
Shu Zhu, Elizabeth E. Eynon, Chiara Borsotti, George D. Yancopoulos, Till Strowig, Cagan Gurer, Andrew J. Murphy, Markus G. Manz, Richard A. Flavell, Davor Frleta, Jean-Nicolas Schickel, Eric Meffre, Hua Yu
Publikováno v:
Blood. 129:959-969
Humanized mice are a powerful tool for the study of human hematopoiesis and immune function in vivo. However, the existing models cannot support robust adaptive immune responses, especially the generation of class-switched, antigen-specific antibody
Autor:
Richard A. Flavell, David M. Valenzuela, George D. Yancopoulos, Markus G. Manz, Wojtek Auerbach, Chozhavendan Rathinam, Sean Stevens, Elizabeth E. Eynon, Hitoshi Takizawa, Anthony Rongvaux, Andrew J. Murphy, Tim Willinger
Hematopoietic stem cells (HSCs) both self-renew and give rise to all blood cells for the lifetime of an individual. Xenogeneic mouse models are broadly used to study human hematopoietic stem and progenitor cell biology in vivo. However, maintenance,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8daccb12ab6dde2f0602de8f36aad625
http://doc.rero.ch/record/324259/files/rongvaux_pnas_2011.pdf
http://doc.rero.ch/record/324259/files/rongvaux_pnas_2011.pdf
Autor:
Markus G. Manz, Chiara Borsotti, Madhav V. Dhodapkar, Mehmet H. Kocoglu, Elizabeth E. Eynon, Richard A. Flavell, Rituparna Das, Lin Zhang, Stephanie Hopf, Anja Hafemann, Srinivas V. Koduru, Rakesh Verma, Till Strowig, Andrew R. Branagan
Publikováno v:
Nature medicine
Most human cancers, including myeloma, are preceded by a precursor state. There is an unmet need for in vivo models to study the interaction of human preneoplastic cells in the bone marrow microenvironment with non-malignant cells. Here, we genetical
Autor:
Sean Stevens, Wojtek Auerbach, Anthony Rongvaux, David Valenzuela, George D. Yancopoulos, Richard A. Flavell, Hitoshi Takizawa, Tim Willinger, Markus G. Manz, Elizabeth E. Eynon, Andrew J. Murphy
Publikováno v:
Proceedings of the National Academy of Sciences. 108:2390-2395
Mice with a functional human immune system have the potential to allow in vivo studies of human infectious diseases and to enable vaccine testing. To this end, mice need to fully support the development of human immune cells, allow infection with hum
Publikováno v:
Nature Immunology. 11:962-968
Induced regulatory T cells (iT(reg) cells) can be generated by peripheral dendritic cells (DCs) that mediate T cell unresponsiveness to rechallenge with antigen. The molecular factors required for the function of such iT(reg) cells remain unknown. We
Autor:
Linda S. Wicker, Elizabeth E. Eynon, Richard A. Flavell, Alexander V. Chervonsky, Dan Rainbow, Masahito Kamanaka, Karin Schuster-Gossler
Publikováno v:
Proceedings of the National Academy of Sciences. 106:11236-11240
Idd3is one of many gene regions that affect the development of type 1 diabetes (T1D) in the nonobese diabetic (NOD) mouse.Idd3has been localized to a 650-kb region on chromosome 3 containing the IL-2 gene. Exon 1 of the IL-2 gene is polymorphic betwe
Autor:
Rudi Balling, Kees Weijer, James P. Di Santo, Patrick Ziegler, Markus G. Manz, Richard A. Flavell, Chozhavendan Rathinam, Pablo D. Becker, Charles M. Rice, Anja U. van Lent, Chiara Borsotti, Nicolas Brezillon, Nicolas Legrand, Elizabeth E. Eynon, Michael Ott, Chengyan Wang, Ype P. de Jong, Jean Jacques Mention, Hélène Strick-Marchand, Stephanie C. Eisenbarth, Sean Stevens, Nicholas D. Huntington, Anthony Rongvaux, Hergen Spits, Alexander Ploss, Hitoshi Takizawa, Dina Kremsdorf, Hongkui Deng, Tim Willinger, Carlos A. Guzmán, Michael Manns, Jennifer Debarry
Publikováno v:
Cell host & microbe, 6(1), 5-9. Cell Press
Over 800 million people worldwide are infected with hepatitis viruses, human immunodeficiency virus (HIV), and malaria, resulting in more than 5 million deaths annually. Here we discuss the potential and challenges of humanized mouse models for devel
Autor:
Richard A. Flavell, Yasushi Kobayashi, Jack A. Elias, Elizabeth E. Eynon, Lark Kyun Kim, Chun Geun Lee, Rimpei Morita, Stephanie C. Eisenbarth
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 112(22)
Significance Millions of people are affected by asthma and that number is growing. A clear understanding of how the disease develops is lacking. The immune responses to inhaled allergens like house dust mite (HDM) provide much of the basis of asthma.
Autor:
Tommy Cedervall, Elizabeth E. Eynon, Xinguo Chen, Sandra L. Wolin, Hong Shi, Derek D. Yang, Dahai Xue, Richard A. Flavell, James D. Smith, Michael Kashgarian, Dennis A. Noe, Douglas E. Brash
Publikováno v:
Proceedings of the National Academy of Sciences. 100:7503-7508
Antibodies against a conserved RNA-binding protein, the Ro 60-kDa autoantigen, occur in 24–60% of all patients with systemic lupus erythematosus. Anti-Ro antibodies are correlated with photosensitivity and cutaneous lesions in these patients and wi