Výsledky vyhledávání - "Elizabeth E Morgan"

Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Biapenem in Healthy Adult Subjects

Autor: Michael N. Dudley, Jeffery S. Loutit, Elizabeth E. Morgan, David C. Griffith

Publikováno v: Antimicrob Agents Chemother

The pharmacokinetics and safety of biapenem were studied in 36 healthy adult subjects in a randomized, placebo-controlled, double blind, sequential single- and multiple-ascending-dose study using doses from 250 to 1,250 mg administered three times a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086564c5eeacaa7793685394efbe84ca
https://doi.org/10.1128/aac.02612-20

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Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Vaborbactam and Meropenem Alone and in Combination following Single and Multiple Doses in Healthy Adult Subjects

Autor: Elizabeth E. Morgan, David C. Griffith, Sujata M. Bhavnani, Jeffery S. Loutit, Michael N. Dudley, Christopher M. Rubino, Dan White

Meropenem-vaborbactam is a fixed combination of the novel β-lactamase inhibitor vaborbactam and the carbapenem antibiotic meropenem, developed for the treatment of serious infections caused by drug-resistant Gram-negative bacteria. The safety, toler

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a68e85175f45c3bae933619d9c08ad
https://europepmc.org/articles/PMC5914003/

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1387. Phase I Study to Evaluate the Safety and Pharmacokinetics (PK) of Single and Multiple Ascending Doses (SAD/MAD) of Intravenous (IV) Minocycline in Healthy Adult Subjects

Autor: Mark A.J. Bayliss, Stefanie Hamacher, Andrew M. Lovering, Dorothee Arenz, Karen Fusaro, Elizabeth E. Morgan, Oliver A. Cornely, Jeffery S. Loutit, Sue Cammarata, Vassiliki Dimitriou, David C. Griffith, Olivier Barraud, Alasdair P. MacGowan

Publikováno v: Open Forum Infectious Diseases

Background Carbapenem-resistant Acinetobacter baumannii infections are defined by the WHO as a critical threat. IV minocycline is approved in the United States for treatment of Acinetobacter infections at doses up to 200 mg BID. This study investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875ab09dc497051a04cef25359f941a9
http://europepmc.org/articles/PMC6252552

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Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of the β-Lactamase Inhibitor Vaborbactam (RPX7009) in Healthy Adult Subjects

Autor: Stephanie Durso, Michael N. Dudley, David C. Griffith, Elizabeth E. Morgan, Jeffery Loutit

Vaborbactam (formerly RPX7009) is a member of a new class of β-lactamase inhibitor with pharmacokinetic properties similar to those of many β-lactams, including carbapenems. The pharmacokinetics and safety of vaborbactam were evaluated in 80 health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a620bf137627543fbd475e1051b7893b
https://europepmc.org/articles/PMC5038296/

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A synthetic androstene derivative and a natural androstene metabolite inhibit relapsing–remitting EAE

Autor: Dominick L. Auci, Agata Matejuk, Halina Offner, Arthur A. Vandenbark, Heather Drought, Elizabeth E Morgan, Christopher L. Reading, Alex Zamora

Publikováno v: Journal of Neuroimmunology. 130:128-139

Experimental allergic encephalomyelitis (EAE), a Th1 polarized demyelinating disease of the central nervous system (CNS), shares many pathological and clinical similarities with multiple sclerosis (MS), and thus represents an attractive animal model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c2c38eba7a86772d203d2c89e5c350
https://doi.org/10.1016/s0165-5728(02)00214-x

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Pharmacokinetics and safety of MP-376 (levofloxacin inhalation solution) in cystic fibrosis subjects

Autor: David E. Geller, Dan White, Jeffery Loutit, Elizabeth E. Morgan, Michael N. Dudley, David C. Griffith, Patrick A. Flume

Publikováno v: Antimicrobial agents and chemotherapy. 55(6)

The pharmacokinetics and tolerability of nebulized MP-376 (levofloxacin inhalation solution [Aeroquin]) were determined in cystic fibrosis (CF) subjects. Ten CF subjects received single 180-mg doses of two formulations of MP-376, followed by a multip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c826ceb4767f952b5dcdee1d9df329d
https://pubmed.ncbi.nlm.nih.gov/21444699

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