Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Elizabeth E, Evans"'
Autor:
Ernest S. Smith, Leslie A. Balch, Maria Scrivens, Shuying Shi, Wei Wang, Caroline D. Harvey, Angelica A. Cornelison, Malgorzata Gil-Moore, Renee A. Kirk, Loretta L. Mueller, Richard L. Hall, Alan P. Howell, Christine A. Reilly, Jessica M. Mayer, Francis G. Murante, Kari A Viggiani, Elaine M. Gersz, Holm Bussler, Madeleine R. Keefe, Elizabeth E. Evans, Mark J. Paris, Maurice Zauderer
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs
Externí odkaz:
https://doaj.org/article/c402db932a18479db56dc8edfe5b355e
Autor:
Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher, Maurice Zauderer
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background The close interaction and interdependence of astrocytes and neurons allows for the possibility that astrocyte dysfunction contributes to and amplifies neurodegenerative pathology. Molecular pathways that trigger reactive astrocyte
Externí odkaz:
https://doaj.org/article/01b6646059f34cdbb38b673af2c1aec2
Autor:
Samuel A. Headley, Donna J. Chapman, Michael J. Germain, Elizabeth E. Evans, Jasmin Hutchinson, Karen L. Madsen, Talat Alp Ikizler, Emily M. Miele, Kristyn Kirton, Elizabeth O’Neill, Allen Cornelius, Brian Martin, Bradley Nindl, Nosratola D. Vaziri
Publikováno v:
BMC Nephrology, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Chronic kidney disease (CKD) is characterized by dysbiosis, elevated levels of uremic toxins, systemic inflammation, and increased markers of oxidative stress. These factors lead to an increased risk of cardiovascular disease (CVD
Externí odkaz:
https://doaj.org/article/b43235108788470d97b1e08ef039af1c
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Analysis and statistics for tumor growth, survival and CR: Immunohistochemistry methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7f9c6525bdc53d65ad79007e8f1a18
https://doi.org/10.1158/2326-6066.22538348
https://doi.org/10.1158/2326-6066.22538348
Autor:
Clint T. Allen, Elizabeth E. Evans, Maurice Zauderer, Ernest Smith, Ellen C. Moore, Yvette Robbins, Jay Friedman, Paul E. Clavijo
Demonstrates peripheral MDSC changes, tumor effector immune cell changes and ex vivo T-cell functional data important to a thorough understanding of how Sema4D blockade alters tumor immunity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b5badea67c47b5c27378442d53dcf9f
https://doi.org/10.1158/2326-6066.22539299
https://doi.org/10.1158/2326-6066.22539299
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Supplementary Figure S1: SEMA4D and PLXNB1 are highly expressed in human cancer. Supplementary Figure S2: SEMA4D gradient at tumor leading edge. Supplementary Figure S3: Tumor volumes of mice selected for immune cell characterization and functional a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3e741fdd3c1064046f9b7911f212d3
https://doi.org/10.1158/2326-6066.22538351.v1
https://doi.org/10.1158/2326-6066.22538351.v1
Autor:
Clint T. Allen, Elizabeth E. Evans, Maurice Zauderer, Ernest Smith, Ellen C. Moore, Yvette Robbins, Jay Friedman, Paul E. Clavijo
Tumor infiltration by immunosuppressive myeloid cells, such as myeloid-derived suppressor cells (MDSCs), causes resistance to immunotherapy. Semaphorin4D, originally characterized for its axonal guidance properties, also contributes to endothelial ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::458388c807fc35990be5c43bdeb12d22
https://doi.org/10.1158/2326-6066.c.6549047.v1
https://doi.org/10.1158/2326-6066.c.6549047.v1
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 (PLXNB1) are broadly expressed in murine and human tumors, and their expression has been shown to correlate with invasive disease in several human tumors. SEMA4D normally functions to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f46dcb34992473e0cbb195d9773fa727
https://doi.org/10.1158/2326-6066.c.6548750.v1
https://doi.org/10.1158/2326-6066.c.6548750.v1
Autor:
Maurice Zauderer, Jonathan W. Goldman, Rachel E. Sanborn, Aaron S. Mansfield, Yanyan Lou, Nagashree Seetharamu, Alexander I. Spira, Nashat Y. Gabrail, Ramaswamy Govindan, Megan A. Baumgart, Joseph T. Beck, Kevin M. Chin, Andreas Schröder, Vikas Mishra, Ernest Smith, Crystal L. Mallow, Desa Rae E. Pastore, John E. Leonard, Elizabeth E. Evans, Terrence L. Fisher, Michael R. Shafique
Correlative biomarker analysis: 4A, Shift in balance of tumoral myeloid cells correlates with response. 4B, Baseline circulating AMC and ANC correlate with PFS 4C, High baseline circulating AMC:ALC is associated with disease progression and resistanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc177fe3c052bf46df5128bae056d45
https://doi.org/10.1158/1078-0432.22480740
https://doi.org/10.1158/1078-0432.22480740
Autor:
Maurice Zauderer, Jonathan W. Goldman, Rachel E. Sanborn, Aaron S. Mansfield, Yanyan Lou, Nagashree Seetharamu, Alexander I. Spira, Nashat Y. Gabrail, Ramaswamy Govindan, Megan A. Baumgart, Joseph T. Beck, Kevin M. Chin, Andreas Schröder, Vikas Mishra, Ernest Smith, Crystal L. Mallow, Desa Rae E. Pastore, John E. Leonard, Elizabeth E. Evans, Terrence L. Fisher, Michael R. Shafique
Purpose:The CLASSICAL-Lung clinical trial tested the combination of pepinemab, an IgG4 humanized mAb targeting semaphorin 4D, with the PD-L1 inhibitor avelumab to assess the effects of coupling increased T-cell infiltration and reversal of immune sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebdab1c9a3a1ce376eb6393cd1c40228
https://doi.org/10.1158/1078-0432.c.6530526
https://doi.org/10.1158/1078-0432.c.6530526