Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Elizabeth DeLassus"'
Publikováno v:
Biology Open, Vol 7, Iss 2 (2018)
Site-1 protease (S1P) is a proprotein convertase with essential functions in the conversion of precursor proteins to their active form. In earlier studies, we demonstrated that S1P ablation in the chondrocyte lineage results in a drastic reduction in
Externí odkaz:
https://doaj.org/article/79e78cfc37674e6da327e57987e03148
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105674 (2014)
The proprotein convertase site-1 protease (S1P) converts latent ER-membrane bound transcription factors SREBPs and ATF6 to their active forms. SREBPs are involved in cholesterol and fatty acid homeostasis whereas ATF6 is involved in unfolded protein
Externí odkaz:
https://doaj.org/article/c8c68ee8b4624b518e961f04024cd8e4
Publikováno v:
Journal of Nuclear Medicine. 59:1551-1557
Multiple myeloma (MM) is a debilitating neoplasm of terminally differentiated plasma B-cells that has resulted in over 13,000 deaths in 2017 alone. Combination therapies involving melphalan, a small molecule DNA alkylating agent, are commonly prescri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db6b1849acac727416f51a6082c3ea07
https://doi.org/10.2967/jnumed.118.208744
https://doi.org/10.2967/jnumed.118.208744
Publikováno v:
Biology Open
Biology Open, Vol 7, Iss 2 (2018)
Biology Open, Vol 7, Iss 2 (2018)
Site-1 protease (S1P) is a proprotein convertase with essential functions in the conversion of precursor proteins to their active form. In earlier studies, we demonstrated that S1P ablation in the chondrocyte lineage results in a drastic reduction in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c75e0d9ec71bc54178183f5563a0505
https://doi.org/10.1242/bio.032094
https://doi.org/10.1242/bio.032094
Publikováno v:
Matrix Biology. 34:154-160
Type II collagen is the major collagenous component of the cartilage extracellular matrix; formation of a covalently cross-linked type II collagen network provides cartilage with important tensile properties. The Col2a1 gene is encoded by 54 exons, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78777d992f4c202097f515aa7a6f9feb
https://doi.org/10.1016/j.matbio.2013.10.014
https://doi.org/10.1016/j.matbio.2013.10.014
Publikováno v:
Tissue Engineering Part A. 19:1199-1208
The aim of this study was to investigate the effects of serum and compressive dynamic loading on the cartilaginous matrix spatiotemporal distribution around chondrocytes in vitro. Murine chondrocytes suspended in agarose were cultured in serum-free m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e08a4d130ec5f0aa46e6f74227207d
https://doi.org/10.1089/ten.tea.2012.0559
https://doi.org/10.1089/ten.tea.2012.0559
Publikováno v:
Osteoarthritis and Cartilage. 24:S131-S132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e252be3aaea11c0ca1f6485f82269a
Publikováno v:
Methods in Molecular Biology ISBN: 9781493916184
Immunohistochemistry (IHC) is the process of identifying proteins in tissue sections by incubating the sample with antibodies specific to the protein of interest, and then visualizing the bound antibody using a chromogen. Unlike in situ hybridization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2855f85c6969f582434e92ea6a6a4f23
https://doi.org/10.1007/978-1-4939-1619-1_8
https://doi.org/10.1007/978-1-4939-1619-1_8
Publikováno v:
The Journal of biological chemistry. 286(33)
Site-1 protease (S1P) is a proprotein convertase with essential functions in lipid homeostasis and unfolded protein response pathways. We previously studied a mouse model of cartilage-specific knock-out of S1P in chondroprogenitor cells. These mice e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa84ccc88184dc5ded1d1f72276bd30
https://pubmed.ncbi.nlm.nih.gov/21652717
https://pubmed.ncbi.nlm.nih.gov/21652717
Publikováno v:
Osteoarthritis and Cartilage. 18
caused an upregulation of SOX9 and enhanced extracellular matrix protein production. Conclusions: Depletion of PHD2 resulted in greater HIF-2α levels, and therefore enhanced SOX9-induced cartilage matrix production compared to the levels normally fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a463b0933b726bae5b2b1cc612e4eb81