Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Elizabeth D. Crane"'
Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging
Autor:
Wesley Wong, Elizabeth D. Crane, Hui Zhang, Jiahe Li, Tovah A. Day, Alex E. Green, Keir J. Menzies, Justin D. Crane
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101575- (2022)
Objective: The epidermal barrier is renewed by the activation, proliferation, and differentiation of keratinocyte stem cells after injury and aging impedes this repair process through undefined mechanisms. We previously identified a gene signature of
Externí odkaz:
https://doaj.org/article/7e3ab768e88f4099a66bb1191480b146
Autor:
Julian M. Yabut, Eric M. Desjardins, Eric J. Chan, Emily A. Day, Julie M. Leroux, Bo Wang, Elizabeth D. Crane, Wesley Wong, Katherine M. Morrison, Justin D. Crane, Waliul I. Khan, Gregory R. Steinberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Serotonin inhibits adipose tissue thermogenesis. Here the authors show that obese mice housed in thermoneutrality have increased mast cell serotonin synthesis, and that inhibiting this pathway through deletion of mast cell Tph1 increases white adipos
Externí odkaz:
https://doaj.org/article/b41caca977ab47c4b862d4ee101f56a3
Autor:
Eric M. Desjardins, Justin D. Crane, Elizabeth D. Crane, Bo Wang, Julie M. Leroux, Julian M. Yabut, Wesley Wong, Gregory R. Steinberg, Waliul I. Khan, Emily A. Day, Eric J. Chan, Katherine M. Morrison
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Obesity is linked with insulin resistance and is characterized by excessive accumulation of adipose tissue due to chronic energy imbalance. Increasing thermogenic brown and beige adipose tissue futile cycling may be an important strategy to increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5039df838407f0e9f7ba1799b945b951
https://doaj.org/article/b41caca977ab47c4b862d4ee101f56a3
https://doaj.org/article/b41caca977ab47c4b862d4ee101f56a3
Publikováno v:
Journal of Investigative Dermatology. 141:2170-2177.e3
Epidermal keratinocytes (KCs) rapidly proliferate to repair the skin barrier, and a strict control of division is necessary for healthy tissue homeostasis. However, the pathways that restrain proliferation after epidermal stress are not known. AMPK i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c5566138ce532284e6c5504cc086573
https://doi.org/10.1016/j.jid.2020.12.036
https://doi.org/10.1016/j.jid.2020.12.036
Publikováno v:
J Biol Chem
Impaired wound healing in elderly individuals increases infection risk and prolongs surgical recovery, but current treatment options are limited. Low doses of interleukin-15 (IL-15) that mimic exercise responses in the circulation improve skin struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5430526c563986aa06aec35272c2f66
https://pubmed.ncbi.nlm.nih.gov/31748415
https://pubmed.ncbi.nlm.nih.gov/31748415
Publikováno v:
SSRN Electronic Journal.
Epidermal stem cells (ESCs) rapidly proliferate to repair the skin barrier and a strict control of division is necessary to sustain stem cell growth capacity. AMP-activated protein kinase (AMPK) is an important signaling mediator of energy metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85d0e335027f7ddf3df84f2d2e7143d9
https://doi.org/10.2139/ssrn.3468490
https://doi.org/10.2139/ssrn.3468490
Autor:
Joan C. Krepinsky, Serena Marchiò, Khrystyna Platko, Ali Al-Hashimi, Jack Chen, Jae Hyun Byun, Magda Naeim, Wadih Arap, Richard C. Austin, Katey J. Rayner, Šárka Lhoták, Elizabeth D. Crane, Renata Pasqualini, Edward G. Lynn, Bobby Shayegan, Paul Lebeau, Kevin Doyoon Won
Publikováno v:
JCI insight. 3(24)
The 78-kDa glucose-regulated protein (GRP78) is an ER molecular chaperone that aids in protein folding and secretion. However, pathological conditions that cause ER stress can promote the relocalization of GRP78 to the cell surface (csGRP78), where i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2016c74739c36ed103fc9d02010a8a0
https://pubmed.ncbi.nlm.nih.gov/30568038
https://pubmed.ncbi.nlm.nih.gov/30568038
Autor:
Elizabeth D Crane, Richard C Austin
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Damage to the endothelium is an important contributor to the initiation and progression of atherosclerosis. GRP78 is a molecular chaperone localized to the endoplasmic reticulum (ER) in healthy cells that functions to assist in the correct folding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22a3ace1c9e4e5e3e8e05cc03be10559
https://doi.org/10.1161/atvb.34.suppl_1.256
https://doi.org/10.1161/atvb.34.suppl_1.256
Publikováno v:
Immunobiology. 215(7)
Stat6 is a transcription factor that regulates important cellular processes such as proliferation, differentiation, and survival through mediating IL-4 and IL-13 signaling. Importantly, increasing evidence indicates of a role for Stat6 in lymphoproli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a23e1e55792d008fb56e029364879e
https://pubmed.ncbi.nlm.nih.gov/19822376
https://pubmed.ncbi.nlm.nih.gov/19822376
Autor:
Richard C. Austin, Elizabeth D. Crane
Publikováno v:
Atherosclerosis. 235:e119
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a68eea67b47647d64fdc14e25c61b3ef
https://doi.org/10.1016/j.atherosclerosis.2014.05.325
https://doi.org/10.1016/j.atherosclerosis.2014.05.325