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pro vyhledávání: '"Elizabeth Choe Yu"'
Ensemble Force Changes that Result from Human Cardiac Myosin Mutations and a Small-Molecule Effector
Publikováno v:
Cell Reports, Vol 11, Iss 6, Pp 910-920 (2015)
Cardiomyopathies due to mutations in human β-cardiac myosin are a significant cause of heart failure, sudden death, and arrhythmia. To understand the underlying molecular basis of changes in the contractile system’s force production due to such mu
Externí odkaz:
https://doaj.org/article/e6c9674fea2f468a8941bc6a6a9f0cc9
Autor:
Leslie A. Leinwand, Masataka Kawana, Elizabeth Choe Yu, Kathleen M. Ruppel, Marina Svicevic, Carlos Vera, Srbolujub M. Mijailovich, Michael A. Geeves, James A. Spudich, Zoltan Ujfalusi
Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) can cause arrhythmias, heart failure, and cardiac death. Here, we functionally characterized the motor domains of five DCM-causing mutations in human β-cardiac myosin. Kinetic analys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d6e19edeaa92f6cb261ba85a21c9f0
Autor:
Kathleen M. Ruppel, Darshan V. Trivedi, Shirley Sutton, Arjun S. Adhikari, James A. Spudich, Masataka Kawana, Sadie Bartholomew, Rebecca E. Taylor, Suman Nag, Chao Liu, Tural Aksel, Elizabeth Choe Yu, Ruth F. Sommese, Jongmin Sung, Carol Cho, Saswata S. Sarkar
Publikováno v:
The Journal of experimental biology. 219(Pt 2)
Hypertrophic cardiomyopathy is the most frequently occurring inherited cardiovascular disease, with a prevalence of more than one in 500 individuals worldwide. Genetically acquired dilated cardiomyopathy is a related disease that is less prevalent. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c45730d7cb2372f83a376d12543085b7
https://pubmed.ncbi.nlm.nih.gov/26792326
https://pubmed.ncbi.nlm.nih.gov/26792326
Autor:
Spudich, James A., Aksel, Tural, Bartholomew, Sadie R., Suman Nag, Masataka Kawana, Elizabeth Choe Yu, Sarkar, Saswata S., Jongmin Sung, Sommese, Ruth F., Sutton, Shirley, Cho, Carol, Adhikari, Arjun S., Taylor, Rebecca, Chao Liu, Trivedi, Darshan, Ruppel, Kathleen M.
Publikováno v:
Journal of Experimental Biology; Jan2016, Vol. 219 Issue 2, p161-167, 7p