Výsledky vyhledávání - "Elizabeth Chimbayo"

Akademický článek

Airway CD8+CD161++TCRvα7.2+ T Cell Depletion During Untreated HIV Infection Targets CD103 Expressing Cells

Autor: Leonard Mvaya, Andrew Mwale, Annemarie Hummel, Joseph Phiri, Raphael Kamng'ona, David Mzinza, Elizabeth Chimbayo, Rose Malamba, Anstead Kankwatira, Henry C. Mwandumba, Kondwani C. Jambo

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

HIV-infected adults are at an increased risk to lower respiratory tract infections (LRTIs). CD8+CD161++TCRvα7.2+ T cells are an innate-like T cell subset that are thought to play an important role in early defense against pathogens in the respirator

Externí odkaz: https://doaj.org/article/f48f3c96b32e4a81af2e1395af31102e

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Akademický článek

B cell, CD8+ T cell and gamma delta T cell infiltration alters alveolar immune cell homeostasis in HIV-infected Malawian adults [version 3; referees: 2 approved, 1 approved with reservations]

Autor: Andrew Mwale, Annemarie Hummel, Leonard Mvaya, Raphael Kamng'ona, Elizabeth Chimbayo, Joseph Phiri, Rose Malamba, Anstead Kankwatira, Henry C Mwandumba, Kondwani C Jambo

Publikováno v: Wellcome Open Research, Vol 2 (2018)

Background: HIV infection is associated with increased risk to lower respiratory tract infections (LRTI). However, the impact of HIV infection on immune cell populations in the lung is not well defined. We sought to comprehensively characterise the i

Externí odkaz: https://doaj.org/article/e9c1b647a68640a8ad4ed67762240779

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Akademický článek

B cell, CD8 + T cell and gamma delta T cell infiltration alters alveolar immune cell homeostasis in HIV-infected Malawian adults [version 2; referees: 1 approved, 2 approved with reservations]

Autor: Andrew Mwale, Annemarie Hummel, Leonard Mvaya, Raphael Kamng'ona, Elizabeth Chimbayo, Joseph Phiri, Rose Malamba, Anstead Kankwatira, Henry C Mwandumba, Kondwani C Jambo

Publikováno v: Wellcome Open Research, Vol 2 (2017)

Externí odkaz: https://doaj.org/article/131c58ca29dc4bd196cc9060de2c364d

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Akademický článek

Functional Analysis of Phagocyte Activity in Whole Blood from HIV/Tuberculosis-Infected Individuals Using a Novel Flow Cytometry-Based Assay

Autor: Ankur Gupta-Wright, Dumizulu Tembo, Kondwani C. Jambo, Elizabeth Chimbayo, Leonard Mvaya, Shannon Caldwell, David G. Russell, Henry C. Mwandumba

Publikováno v: Frontiers in Immunology, Vol 8 (2017)

The accurate assessment of immune competence through ex vivo analysis is paramount to our understanding of those immune mechanisms that lead to protection or susceptibility against a broad range of human pathogens. We have developed a flow cytometry-

Externí odkaz: https://doaj.org/article/f326c7e323a342daa73374371642c844

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TZM-gfp cells: a tractable fluorescent tool for analysis of rare and early HIV-1 infection

Autor: Elizabeth Chimbayo, David G. Russell, David W. Gludish, Henry C. Mwandumba, Kondwani C. Jambo, Dumizulu L. Tembo, Shannon Caldwell, Saikat Boliar

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports

Here we describe TZM-gfp, a novel HIV-1 reporter cell derived from the same parental clone JC.53, used previously to generate the widely-utilized indicator cell line TZM-bl. We re-engineered JC.53 cells to express GFP under regulation of HIV Tat and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72264716cf36568761424663c146896d
http://link.springer.com/article/10.1038/s41598-020-76422-6

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Virological failure, HIV-1 drug resistance, and early mortality in adults admitted to hospital in Malawi: an observational cohort study

Autor: Daniel Grint, Judith Heaney, Henry C. Mwandumba, Ankur Gupta-Wright, Matthew Byott, Ravindra K. Gupta, Melanie Alufandika, Katherine Fielding, Elizabeth L. Corbett, Joep J. van Oosterhout, Elizabeth Chimbayo, Eleni Nastouli

Publikováno v: The Lancet. HIV

Summary Background Antiretroviral therapy (ART) scale-up in sub-Saharan Africa combined with weak routine virological monitoring has driven increasing HIV drug resistance. We investigated ART failure, drug resistance, and early mortality among patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e246171e543cc973196914a748eac754
https://doi.org/10.1016/s2352-3018(20)30172-7

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Something Old, Something New: Ion Channel Blockers as Potential Anti-Tuberculosis Agents

Autor: Christine Mandalasi, Elizabeth Chimbayo, Agness Lakudzala, David Mzinza, Henry C. Mwandumba, David V Mhango, Kondwani C. Jambo, Steven C. Mitini-Nkhoma, Aaron P. Chirambo, Dumizulu L. Tembo

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology

Tuberculosis (TB) remains a challenging global health concern and claims more than a million lives every year. We lack an effective vaccine and understanding of what constitutes protective immunity against TB to inform rational vaccine design. Moreov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb052b073773d326f77c70246ba1ee5c

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Virological Failure, HIV-1 Drug Resistance and Early Mortality in Adults Admitted to Hospital in Malawi: A Nested Observational Cohort Study

Autor: Melanie Alufandika, Katherine Fielding, Joep J van Oosterhout, Ravindra K. Gupta, Ankur Gupta-Wright, Henry C. Mwandumba, Matthew Byott, Daniel Grint, Judith Heaney, Elizabeth L. Corbett, Elizabeth Chimbayo, Eleni Nastouli

Publikováno v: SSRN Electronic Journal.

Background: Antiretroviral therapy (ART) scale-up in sub-Saharan Africa (SSA) combined with weak routine virological monitoring has driven increasing HIV drug resistance. We investigated ART failure, drug resistance and early mortality among hospital

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0df06870461b7d823d69a3787da672
https://doi.org/10.2139/ssrn.3562473

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