Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury

Autor: Lakhmir S. Chawla, Segav Demirjian, Shai Erlich, Gorav Ailawadi, Samina Khan, Martin Polinsky, Marta Hamilton, Shuli Silberman, Stanton K. Shernan, Elizabeth C. Squiers, Dani Bitran, Michel Burnier, Daniel Rothenstein

Publikováno v: Kidney international reports, vol. 2, no. 5, pp. 836-843
Kidney International Reports
Kidney International Reports, Vol 2, Iss 5, Pp 836-843 (2017)

Introduction Patients undergoing on-pump cardiac surgery are at an increased risk of acute kidney injury. QPI-1002, a small interfering ribonucleic acid, is under clinical development for the prevention of acute kidney injury. The safety, tolerabilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b07989eac680fccff3044ff333d6d6
https://doi.org/10.1016/j.ekir.2017.03.016

YSPSL (rPSGL-Ig) for improvement of early renal allograft function: a double-blind, placebo-controlled, multi-center Phase IIa study

Autor: A Osama, Gaber, Shamkant, Mulgaonkar, Barry D, Kahan, E Steve, Woodle, Rita, Alloway, Iman, Bajjoka, Stephen, Jensik, Goran B, Klintmalm, Pamela R, Patton, Alexander, Wiseman, Gerald, Lipshutz, Jerzy, Kupiec-Weglinski, Lilian W, Gaber, Eliezer, Katz, William, Irish, Elizabeth C, Squiers, Stefan, Hemmerich

Publikováno v: Clinical transplantation. 25(4)

Recombinant P-selectin glycoprotein ligand IgG fusion protein, rPSGL-Ig (YSPSL), a fusion protein of human P-selectin ligand and IgG1-Fc, blocks leukocyte adhesion and protects against ischemia reperfusion injury (IRI) in animal models.This randomize

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5d8393aff1b5aa53f0a116fc1cc6f48a
https://pubmed.ncbi.nlm.nih.gov/20573162

Regimens of IGF-I treatment in fetal pancreas transplantation

Autor: Gregg A. Adams, Larisse Lee, Marcello Maestri, Donald C. Dafoe, Edward J. Alfrey, Elizabeth C. Squiers

Publikováno v: The Journal of surgical research. 68(1)

Transplantation of fetal pancreas (FP) is a potential treatment for diabetes mellitus. FP has remarkable proliferative capacity and may be induced to expand sufficiently to provide a functional beta cell mass in adult recipients. We have demonstrated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d7c4c7a7046eb84ded138bd9241cfd
https://pubmed.ncbi.nlm.nih.gov/9126198

Small bowel transplantation in the mouse: development of a model

Autor: S. E. Kelley, John C. West, Elizabeth C. Squiers

Publikováno v: Microsurgery. 13(6)

The rat has been used as a model to study the significance of graft and host interactions in small bowel transplantation (SBTX). A mouse model of SBTX would allow investigators to apply the knowledge of the well-defined genetics in the mouse to this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196f80b91949dfec264f29e7cc85aa26
https://pubmed.ncbi.nlm.nih.gov/1453939