Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Elizabeth C. Kimball"'
Autor:
Elizabeth C. Kimball, Sarah Quillen, Mary E. Pease, Casey Keuthan, Aru Nagalingam, Donald J. Zack, Thomas V. Johnson, Harry A. Quigley
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Aquaporin 4 is absent from astrocytes in the rodent optic nerve head, despite high expression in the retina and myelinated optic nerve. The purpose of this study was to quantify regional aquaporin channel expression in astrocytes of the porcine and h
Externí odkaz:
https://doaj.org/article/ccc8cec05a494dd98b7445e023863501
Autor:
Elizabeth C. Kimball, Sarah Quillen, Mary E. Pease, Casey Keuthan, Aru Nagalingam, Donald J. Zack, Thomas V. Johnson, Harry A. Quigley
Publikováno v:
PloS one. 17(6)
Aquaporin 4 is absent from astrocytes in the rodent optic nerve head, despite high expression in the retina and myelinated optic nerve. The purpose of this study was to quantify regional aquaporin channel expression in astrocytes of the porcine and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55afab4a7ffbadc3b9cf62a00bfec334
https://pubmed.ncbi.nlm.nih.gov/35709078
https://pubmed.ncbi.nlm.nih.gov/35709078
Autor:
Matthew B. Appell, Ian Pitha, Renee Ti Chou, Abhijit A. Date, Laura M. Ensign, Charles G. Eberhart, Matthew D. Shin, Cynthia A. Berlinicke, Nicole M. Anders, Usha Rai, Hyounkoo Han, Joan L. Jefferys, Henry T. Hsueh, Avelina Hemingway, Elizabeth C. Kimball, Sarah Quillen, Thomas V. Johnson, Justin Hanes, Amy Xiao, Harry A. Quigley, Donald J. Zack, Yoo Chun Kim, Kirby T. Leo, Laolu Ogunnaike, Patricia Kolodziejski, Julie Schaub, Youngwook Kim, Hye Young Kwon
Publikováno v:
Pharmaceutics, Vol 13, Iss 647, p 647 (2021)
Pharmaceutics
Volume 13
Issue 5
Pharmaceutics
Volume 13
Issue 5
Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) is one of the major risk factors for glaucoma onset and progression, and available pharmaceutical interventions are exclusively targeted at IOP low
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73c8122f9d92097a7a2987ac70ebbf1
https://www.mdpi.com/1999-4923/13/5/647
https://www.mdpi.com/1999-4923/13/5/647
Publikováno v:
J R Soc Interface
The deformation of the mouse astrocytic lamina (AL) and adjacent peripapillary sclera (PPS) was measured in response to elevated intraocular pressure. We subjected explanted mouse eyes to inflation testing, comparing control eyes to those 3 days and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fca980a4c6400d6ca7635b2176c5313
https://pubmed.ncbi.nlm.nih.gov/33323053
https://pubmed.ncbi.nlm.nih.gov/33323053
Autor:
Harry A. Quigley, Mary Ellen Pease, Yik Tung Tracy Ling, Elizabeth C. Kimball, Thao D. Nguyen, Joan L. Jefferys
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To conduct quantitative analysis of astrocytic glial fibrillary acidic protein (GFAP), actin and nuclei distribution in mouse optic nerve (ON) and investigate changes in the measured features after 3 days of ocular hypertension (OHT). Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ddaa895e0dc2ff99f3b4fdf9fffc8e
http://europepmc.org/articles/PMC7488631
http://europepmc.org/articles/PMC7488631
Autor:
Sarah Quillen, Mary Ellen Pease, Elizabeth C. Kimball, Arina Korneva, Harry A. Quigley, Julie Schaub
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0238104 (2020)
PLoS ONE
PLoS ONE
PurposeTo delineate responses of optic nerve head astrocytes to sustained intraocular pressure (IOP) elevation in mice.MethodsWe elevated IOP for 1 day to 6 weeks by intracameral microbead injection in 4 strains of mice. Astrocyte alterations were st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f032e72c3e04dbe443edfe45c915a2d
https://doaj.org/article/2b1b02d983cc40838ead85526bc50102
https://doaj.org/article/2b1b02d983cc40838ead85526bc50102
Autor:
Elizabeth C. Kimball, Mary Ellen Pease, Ericka N. Oglesby, Cathy Nguyen, Julie Schaub, Joan L. Jefferys, Ian Pitha, Harry A. Quigley
Publikováno v:
Experimental Eye Research. 172:78-85
The purpose of this study was to compare younger and older mice after chronic intraocular pressure (IOP) elevation lasting up to 4 days with respect to mitochondrial density, structure, and movement, as well as axonal integrity, in an ex vivo explant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b2130208a7a0a3bd6d42fe977088dc
https://doi.org/10.1016/j.exer.2018.04.001
https://doi.org/10.1016/j.exer.2018.04.001
Autor:
Dan Midgett, Elizabeth C. Kimball, Thao D. Nguyen, Mary Ellen Pease, Harry A. Quigley, Cathy Nguyen, Julie Schaub, Joan L. Jefferys
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The purpose of this study was to measure the full-field deformation response to IOP change in the peripapillary sclera (PPS) and astrocytic lamina cribrosa (ALC) of young and old mouse eyes ex vivo. Methods Thirty-eight transgenic reporter mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b317e960aeaa4595dc0d72fb8813e4
http://europepmc.org/articles/PMC6516562
http://europepmc.org/articles/PMC6516562
Autor:
Cathy Nguyen, Ericka N. Oglesby, Matthew R. Steinhart, Ian Pitha, Elizabeth C. Kimball, Harry A. Quigley, Mary Ellen Pease
Publikováno v:
Experimental Eye Research. 160:106-115
We developed an explant model of the mouse eye and optic nerve that facilitates the study of retinal ganglion cell axons and mitochondria in the living optic nerve head (ONH) in an ex vivo environment. Two transgenic mouse strains were used, one expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef3a63eeb6d657f341d55db618454dd
https://doi.org/10.1016/j.exer.2017.04.003
https://doi.org/10.1016/j.exer.2017.04.003
Publikováno v:
Exp Eye Res
Scleral fibroblast activation occurs in glaucomatous and myopic eyes. Here we perform an unbiased screen to identify kinase inhibitors that reduce fibroblast activation to diverse stimuli in vitro and to in vivo intraocular pressure (IOP) elevation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1eb567d03f14dba99a187ba5dc4d2b4
https://pubmed.ncbi.nlm.nih.gov/32179077
https://pubmed.ncbi.nlm.nih.gov/32179077