Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Elizabeth C Hinchy"'
Autor:
Alba Signes, Raffaele Cerutti, Anna S Dickson, Cristiane Benincá, Elizabeth C Hinchy, Daniele Ghezzi, Rosalba Carrozzo, Enrico Bertini, Michael P Murphy, James A Nathan, Carlo Viscomi, Erika Fernandez‐Vizarra, Massimo Zeviani
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 1, Pp 1-21 (2018)
Abstract Loss‐of‐function mutations in APOPT1, a gene exclusively found in higher eukaryotes, cause a characteristic type of cavitating leukoencephalopathy associated with mitochondrial cytochrome c oxidase (COX) deficiency. Although the genetic
Externí odkaz:
https://doaj.org/article/215a8a7301c4477ba2ac4a4276753ce7
Autor:
Francesco Vacca, Caroline Chauché, Abhishek Jamwal, Elizabeth C Hinchy, Graham Heieis, Holly Webster, Adefunke Ogunkanbi, Zala Sekne, William F Gregory, Martin Wear, Georgia Perona-Wright, Matthew K Higgins, Josquin A Nys, E Suzanne Cohen, Henry J McSorley
Publikováno v:
eLife, Vol 9 (2020)
The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoides polygyrus, which binds and blocks IL-33. Here, we identify H. polygyru
Externí odkaz:
https://doaj.org/article/33d967843f4146868a42245249420393
Autor:
Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulatin
Externí odkaz:
https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a
Autor:
Elizabeth England, D. Gareth Rees, Ian Christopher Scott, Sara Carmen, Denice T. Y. Chan, Catherine E. Chaillan Huntington, Kirsty F. Houslay, Teodor Erngren, Mark Penney, Jayesh B. Majithiya, Laura Rapley, Dorothy A. Sims, Claire Hollins, Elizabeth C. Hinchy, Martin D. Strain, Benjamin P. Kemp, Dominic J. Corkill, Richard D. May, Katherine A. Vousden, Robin J. Butler, Tomas Mustelin, Tristan J. Vaughan, David C. Lowe, Caroline Colley, E. Suzanne Cohen
Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease. Here, we describe the identification of tozorakimab (ME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2623b7a64721c16cead1782c6553f513
https://doi.org/10.1101/2023.02.28.527262
https://doi.org/10.1101/2023.02.28.527262
Autor:
Laura Tronci, Ana S. H. Costa, Efterpi Nikitopoulou, Krishnaa T. Mahbubani, Thomas Krieg, Jack Martin, Fay M Allen, Angela Logan, Timothy E. Beach, Elizabeth C. Hinchy, Kourosh Saeb-Parsy, Margaret M. Huang, Christian Frezza, Richard C. Hartley, Alan J. Robinson, Laura Pala, Michael P. Murphy, Hiran A. Prag, Mazin Hamed, Anja V. Gruszczyk, Andrew M. James, Stuart T. Caldwell
Publikováno v:
Nature metabolism
During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient1,2. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54eee6ea96375ae5f76308148cf2c23f
https://doi.org/10.1038/s42255-019-0115-y
https://doi.org/10.1038/s42255-019-0115-y
Autor:
Zala Sekne, E. Suzanne Cohen, Georgia Perona-Wright, Matthew K. Higgins, Martin A. Wear, William F Gregory, Elizabeth C Hinchy, Adefunke Ogunkanbi, Graham Heieis, Abhishek Jamwal, Francesco Vacca, Henry J. McSorley, Holly Webster, Josquin A Nys, Caroline Chauché
Publikováno v:
Vacca, F, Chauché, C, Jamwal, A, Hinchy, E C, Heieis, G, Webster, H, Ogunkanbi, A, Sekne, Z, Gregory, W F, Wear, M, Perona-Wright, G, Higgins, M K, Nys, J A, Cohen, E S & Mcsorley, H J 2020, ' A helminth-derived suppressor of ST2 blocks allergic responses ', eLIFE, vol. 9, e54017 . https://doi.org/10.7554/eLife.54017
eLife, Vol 9 (2020)
eLife
eLife, Vol 9 (2020)
eLife
The IL-33-ST2 pathway is an important initiator of type 2 immune responses. We previously characterised the HpARI protein secreted by the model intestinal nematode Heligmosomoides polygyrus, which binds and blocks IL-33. Here, we identify H. polygyru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d50e157d7547282bee91dad218a400a
https://doi.org/10.7554/elife.54017
https://doi.org/10.7554/elife.54017
Autor:
Graham Heieis, Francesco Vacca, Matthew K. Higgins, Abhishek Jamwal, Caroline Chauché, William F Gregory, Elizabeth C Hinchy, Holly Webster, Zala Sekne, Henry J. McSorley, E. Suzanne Cohen, Martin A. Wear, Adefunke Ogunkanbi, Josquin A Nys, Georgia Perona-Wright
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6086f59da8b646daeed652f591101679
https://doi.org/10.7554/elife.54017.sa2
https://doi.org/10.7554/elife.54017.sa2
Autor:
Thomas Krieg, Naveenan Navaratnam, Thomas P. Bright, Robin Willows, Michael P. Murphy, David Carling, Andrew R. Hall, Elizabeth C. Hinchy, Anja V. Gruszczyk, Georgina Bates
Publikováno v:
The Journal of Biological Chemistry
Mitochondrial reactive oxygen species (ROS) production is a tightly regulated redox signal that transmits information from the organelle to the cell. Other mitochondrial signals, such as ATP, are sensed by enzymes, including the key metabolic sensor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaa64697d93b99a467072ee7b38115b
https://doi.org/10.1074/jbc.ra118.002579
https://doi.org/10.1074/jbc.ra118.002579
Autor:
Moises Di Sante, Fabio Di Lisa, Richard C. Hartley, Thomas Krieg, Anja V. Gruszczyk, Andrew R. Hall, Nils Burger, John F. Mulvey, Elizabeth C. Hinchy, Michael P. Murphy, Stuart T. Caldwell, Nina Kaludercic, Soni Deshwal, Salvatore Antonucci
Publikováno v:
Free Radical Biology & Medicine
Reactive oxygen species (ROS) have an equivocal role in myocardial ischaemia reperfusion injury. Within the cardiomyocyte, mitochondria are both a major source and target of ROS. We evaluate the effects of a selective, dose-dependent increase in mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df404c5f48b6843945815be65fb4b02d
https://www.repository.cam.ac.uk/handle/1810/289661
https://www.repository.cam.ac.uk/handle/1810/289661
Autor:
Richard G. Carroll, Elizabeth C. Hinchy, Vincent P. Kelly, Eva M. Palsson-McDermott, Moritz Haneklaus, Elektra K. Robinson, Andrew M. James, Louise K. Modis, Silvia Galván-Peña, Michael P. Murphy, Alan Nadin, Sergio Covarrubias, Susan Carpenter, Carla F. Newman, Luke A. J. O'Neill
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Macrophages undergo metabolic changes during activation that are coupled to functional responses. The gram negative bacterial product lipopolysaccharide (LPS) is especially potent at driving metabolic reprogramming, enhancing glycolysis and altering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b634af5584f47f1d546a4bcfc38aa5c8
https://escholarship.org/uc/item/4wq0v1m2
https://escholarship.org/uc/item/4wq0v1m2