Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Elizabeth C George"'
Autor:
Sophie Uyoga, William Okiror, Diana M Gibb, Peter Olupot-Olupot, Rita Muhindo, Elizabeth C George, Kathryn Maitland, Thomas N Williams, David M Burger, Rob terHeine, Roisin Connon, Britta Urban, A Sarah Walker, Hellen Mnjalla, Ayub Mpoya
Publikováno v:
Wellcome Open Research, Vol 6 (2023)
Background: African children with severe malaria are susceptible to Gram-negative bacterial co-infection, largely non-typhoidal Salmonellae, leading to a substantially higher rates of in-hospital and post-discharge mortality than those without bacter
Externí odkaz:
https://doaj.org/article/f30b58cff2d847ec8fbfff74091d4812
Autor:
James A Watson, Carolyne M Ndila, Sophie Uyoga, Alexander Macharia, Gideon Nyutu, Shebe Mohammed, Caroline Ngetsa, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Kirk Rockett, Stije Leopold, Hugh Kingston, Elizabeth C George, Kathryn Maitland, Nicholas PJ Day, Arjen M Dondorp, Philip Bejon, Thomas N Williams, Chris C Holmes, Nicholas J White
Publikováno v:
eLife, Vol 10 (2021)
Severe falciparum malaria has substantially affected human evolution. Genetic association studies of patients with clinically defined severe malaria and matched population controls have helped characterise human genetic susceptibility to severe malar
Externí odkaz:
https://doaj.org/article/9975f68439c94b6da46fbbde7cbac9a5
Autor:
Peter Olupot-Olupot, Florence Aloroker, Ayub Mpoya, Hellen Mnjalla, George Passi, Margaret Nakuya, Kirsty Houston, Nchafatso Obonyo, Mainga Hamaluba, Jennifer A Evans, Roisin Connon, Elizabeth C George, Diana M Gibb, Kathryn Maitland
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Children hospitalised with severe acute malnutrition (SAM) are frequently complicated (>50%) by diarrhoea (≥3 watery stools/day) which is accompanied by poor outcomes. Rehydration guidelines for SAM are exceptionally conservative and co
Externí odkaz:
https://doaj.org/article/adc18d3c71514a5f80faacbe9cd2b647
Autor:
Kathryn Maitland, ProfPhD, Peter Olupot-Olupot, PhD, Sarah Kiguli, MMED, George Chagaluka, MD, Florence Alaroker, MMED, Robert O Opoka, MMED, Ayub Mpoya, MSc, Kevin Walsh, MRes, Charles Engoru, MMED, Julius Nteziyaremye, MBChB, Machpherson Mallewa, PhD, Neil Kennedy, MD, Margaret Nakuya, MBChB, Cate Namayanja, MBChB, Julianne Kayaga, MBChB, Eva Nabawanuka, MBChB, Tonny Sennyondo, EGN, Denis Aromut, BSc, Felistas Kumwenda, MSc, Cynthia Williams Musika, BSc, Margaret J Thomason, PhD, Imelda Bates, PhD, Michael Boele von Hensbroek, ProfMD, Jennifer A Evans, MD, Sophie Uyoga, PhD, Thomas N Williams, ProfPhD, Gary Frost, ProfPhD, Elizabeth C George, PhD, Diana M Gibb, ProfMD, A Sarah Walker, ProfPhD
Publikováno v:
The Lancet Global Health, Vol 7, Iss 10, Pp e1435-e1447 (2019)
Summary: Background: Severe anaemia is a leading cause of paediatric admission to hospital in Africa; post-discharge outcomes remain poor, with high 6-month mortality (8%) and re-admission (17%). We aimed to investigate post-discharge interventions t
Externí odkaz:
https://doaj.org/article/9c14042825dc41bdad3570074e1a59ee
Autor:
Kirsty A. Houston, Jack G. Gibb, Ayub Mpoya, Nchafatso Obonyo, Peter Olupot-Olupot, Margeret Nakuya, Jennifer A Evans, Elizabeth C George, Diana M Gibb, Kathryn Maitland
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
Background: The World Health Organization (WHO) rehydration management guidelines (Plan C) for children with acute gastroenteritis (AGE) and severe dehydration are widely practiced in resource-poor settings, yet have never been formally evaluated in
Externí odkaz:
https://doaj.org/article/aaa057982ab64b37b7a464562835ce8e
Autor:
Mainga Hamaluba, Thomas N. Williams, Christabel Mogoka, Luc Kambale Kamavu, Mike Chaponda, Sam Miti, Nick White, Nick Day, Nchafatso Obonyo, Diana M. Gibb, Elizabeth C. George, Arjen Dondorp, Kathryn Maitland, Roisin Connon, A. Sarah Walker, Jonathan Jonathan Gwasupika, Emmanuel Oguda
Publikováno v:
Wellcome Open Research, Vol 8 (2024)
Background Even on the best antimalarial treatments (injectable artesunate) African children with severe malaria have poor outcomes with most deaths occurring early in the course of hospital admission ( 2mmol/l). Three intravenous doses will be given
Externí odkaz:
https://doaj.org/article/bea332e88bf24e2b9ccc27dbc5720410
Autor:
Mainga Hamaluba, Diana M. Gibb, Elizabeth C. George, Symon M. Kariuki, Kathryn Maitland, Roisin Connon, Nchafasto Obonyo, Christabel Mogaka, Thomas N. Williams, Emmanuel Ogoda, A. Sarah Walker, Charles Newton
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Background African children with cerebral malaria and seizures caused Plasmodium falciparum are at greater risk of poor outcomes including death and neurological sequelae. The agonal events are severe hypoventilation and respiratory arrest often trig
Externí odkaz:
https://doaj.org/article/20e654b8b7c8405cb3538f0ae6f1fe02
Autor:
Mainga Hamaluba, Matthew Coldiron, Kirsty Houston, Temmy Sunyoto, Marie-Francoise SCHERRER, Roisin Connon, Celine LANGENDORF, Roberta PETRUCCI, Nchafatso Obonyo, Diana M. Gibb, Peter Olupot-Olupot, Elizabeth C. George, Jennifer A Evans, Kathryn Maitland, Salifou Atti, Manuel Dewez, Florence Aloroker, San Maurice Ouattara, Ousmane Guindo, Hellen Mnjalla, Omokore Oluseyi Amos, Ayub Mpoya, Abdullahi Chara, Margaret Nakuya, Hadiza Alhaji Sainna, George Paasi, Oluwakemi Ogundipe
Publikováno v:
Wellcome Open Research, Vol 6 (2024)
Background Children hospitalised with severe acute malnutrition (SAM) are frequently complicated (>50%) by diarrhoea ( ≥3 watery stools/day) which is accompanied by poor outcomes. Rehydration guidelines for SAM are exceptionally conservative and co
Externí odkaz:
https://doaj.org/article/e51856fa7d634aa4acea8da3dbd10ab2
Autor:
Mainga Hamaluba, Thomas N. Williams, Christabel Mogoka, Luc Kambale Kamavu, Mike Chaponda, Sam Miti, Nick White, Nick Day, Nchafatso Obonyo, Diana M. Gibb, Elizabeth C. George, Arjen Dondorp, Kathryn Maitland, Roisin Connon, A. Sarah Walker, Emmanuel Oguda
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background Even on the best antimalarial treatments (injectable artesunate) African children with severe malaria have poor outcomes with most deaths occurring early in the course of hospital admission ( 2mmol/l). Three intravenous doses will be given
Externí odkaz:
https://doaj.org/article/6d2fe2fedd614c08b2ceb415315f148f
Autor:
Lamprini Lampro, Elizabeth C. George
Publikováno v:
Tropical Medicine & International Health. 27:767-775
Malaria is one of the most important parasitic infectious diseases worldwide. Despite the scale-up of effective antimalarials, mortality rates from severe malaria (SM) remain significantly high; thus, numerous trials are investigating both antimalari