Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Elizabeth Bartom"'
Autor:
Crismita Dmello, Junfei Zhao, Li Chen, Andrew Gould, Brandyn Castro, Victor A. Arrieta, Daniel Y. Zhang, Kwang-Soo Kim, Deepak Kanojia, Peng Zhang, Jason Miska, Ragini Yeeravalli, Karl Habashy, Ruth Saganty, Seong Jae Kang, Jawad Fares, Connor Liu, Gavin Dunn, Elizabeth Bartom, Matthew J. Schipma, Patrick D. Hsu, Mahmoud S. Alghamri, Maciej S. Lesniak, Amy B. Heimberger, Raul Rabadan, Catalina Lee-Chang, Adam M. Sonabend
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Immunotherapies have shown limited efficacy in patients with glioma. Here, based on an in vivo kinome knockout CRISPR screen, the authors show that checkpoint kinase 2 promotes CD8 T cell immune evasion and that its depletion or inhibition improve su
Externí odkaz:
https://doaj.org/article/add0ff19941e4f458a8e86e32cf2095c
Autor:
Tina Yi-Ting Huang, Andrea Piunti, Jin Qi, Marc Morgan, Elizabeth Bartom, Ali Shilatifard, Amanda M. Saratsis
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V), impairing SETD2 activity (H3K36-specific trimethyltransferase). Consequently, reduced H
Externí odkaz:
https://doaj.org/article/dcbb1c3fc7df43c0a5fd0aa7be97d7ea
Autor:
Zhiqiang Du, Jeniece Regan, Elizabeth Bartom, Wei-Sheng Wu, Li Zhang, Dustin Kenneth Goncharoff, Liming Li
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Abstract Transcriptional regulators are prevalent among identified prions in Saccharomyces cerevisiae, however, it is unclear how prions affect genome-wide transcription. We show here that the prion ([SWI +]) and mutant (swi1∆) forms of Swi1, a sub
Externí odkaz:
https://doaj.org/article/5e69ff4896f947ceb52123ff6e314899
Autor:
Andrea E. Calvert, Alexandra Chalastanis, Yongfei Wu, Lisa A. Hurley, Fotini M. Kouri, Yingtao Bi, Maureen Kachman, Jasmine L. May, Elizabeth Bartom, Youjia Hua, Rama K. Mishra, Gary E. Schiltz, Oleksii Dubrovskyi, Andrew P. Mazar, Marcus E. Peter, Hongwu Zheng, C. David James, Charles F. Burant, Navdeep S. Chandel, Ramana V. Davuluri, Craig Horbinski, Alexander H. Stegh
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1858-1873 (2017)
Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma (GBM). Our in silico and wet-bench analyses indicate that non-mu
Externí odkaz:
https://doaj.org/article/f4d292ac8f8346f8ab26ed8e258f99d4
Autor:
Riyue Bao, Kyle Hernandez, Lei Huang, Wenjun Kang, Elizabeth Bartom, Kenan Onel, Samuel Volchenboum, Jorge Andrade
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135800 (2015)
Whole exome sequencing has facilitated the discovery of causal genetic variants associated with human diseases at deep coverage and low cost. In particular, the detection of somatic mutations from tumor/normal pairs has provided insights into the can
Externí odkaz:
https://doaj.org/article/d7f0061cf18f44488b65f03386c5bf23
Autor:
Angela Stoddart, Megan E. McNerney, Elizabeth Bartom, Rachel Bergerson, David J. Young, Zhijian Qian, Jianghong Wang, Anthony A. Fernald, Elizabeth M. Davis, Richard A. Larson, Kevin P. White, Michelle M. Le Beau
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 3, Iss 1, Pp e2011019-e2011019 (2011)
Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed pro
Externí odkaz:
https://doaj.org/article/4cca1ac43731402e9e66cd18a6746d3d
Autor:
Rachel Bergerson, Elizabeth Bartom, Megan E. McNerney, Angela Stoddart, David J. Young, Zhijian Qian, Jianghong Wang, Anthony A. Fernald, Elizabeth M. Davis, Richard A. Larson, Kevin P. White, Michelle M. Le Beau
Publikováno v:
Mediterranean Journal of Hematology and Infectious Diseases, Vol 3, Iss 1, Pp e2011019-e2011019 (2011)
Therapy-related myeloid neoplasm (t-MN) is a distinctive clinical syndrome occurring after exposure to chemotherapy or radiotherapy. t-MN arises in most cases from a multipotential hematopoietic stem cell or, less commonly, in a lineage committed pro
Externí odkaz:
https://doaj.org/article/edce48df18284491a623fddc199f0841
Autor:
Atieh Hajirahimkhan, Shao-Nong Chen, Guido F Pauli, Elizabeth Bartom, Susan Clare, Seema A Khan
Publikováno v:
Cancer Research. 82:P1-11
Introduction: Breast cancer risk continues to rise following menopause, despite the cessation of ovarian estrogen synthesis. High risk women are often hesitant to take anti-endocrine therapies for breast cancer prevention. Therefore, alternative stra
Autor:
Matthew McCord, Elizabeth Bartom, Kirsten Burdett, Aneta Baran, Frank D. Eckerdt, Irina V. Balyasnikova, Kathleen McCortney, Thomas Sears, Shi-Yuan Cheng, Jann N. Sarkaria, Roger Stupp, Amy B. Heimberger, Atique Ahmed, Charles David James, Craig Horbinski
Publikováno v:
Cancers; Volume 14; Issue 22; Pages: 5494
Adult-type diffusely infiltrating gliomas, of which glioblastoma is the most common and aggressive, almost always recur after treatment and are fatal. Improved understanding of therapy-driven tumor evolution and acquired therapy resistance in gliomas
Autor:
Jason Shapiro, Hsiang-Chun Chang, Zibo Zhao, Zohra Waxali, Bong Jin Hong, Haimei Chen, Justin Geier, Elizabeth Bartom, Adam De Jesus, Farnaz Keyhani-Nejad, Tatsuya Sato, Lucia Ramos-Alonso, Antonia Romero, María Teresa Martínez-Pastor, Shang-Chuan Jiang, Shiv K. Sah-Teli, Liming Li, David Bentrem, Gary Lopaschuk, Issam BEN-SAHRA, Thomas O'Halloran, Ali Shilatifard, Sergi Puig, Joy Bergelson, Peppi Koivunen, Hossein Ardehali
All living cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate anabolic processes are unclear. Here, we report a universal eukaryotic pathway for iron sensing in which m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc8cd20e183fca99db5ec51ad847ce61
https://doi.org/10.21203/rs.3.rs-2042947/v1
https://doi.org/10.21203/rs.3.rs-2042947/v1