Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Elizabeth B. Somers"'
Publikováno v:
Biomarker Insights, Vol 2016, Iss 11, Pp 7-18 (2016)
Externí odkaz:
https://doaj.org/article/3507c4416b604f9f8f49b98dd278b394
Publikováno v:
Biomarker Insights, Vol 2014, Iss 9, Pp 29-37 (2014)
Externí odkaz:
https://doaj.org/article/be4632dbaa714d8ca4350c5a79b9140e
Autor:
Sergei I. Agoulnik, Zoltan Dezso, Bryan E. Hoffman, Natalie C. Twine, Stephen M. Jackson, Daniel J. O'Shannessy, Elizabeth B. Somers
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 13687-13703 (2013)
Folate receptor alpha (FOLR1/FRA) is reported to be overexpressed in epithelial ovarian cancers (EOC), especially the serous histotype. Further, while dysregulation of the folate-dependent 1-carbon cycle has been implicated in tumorogenesis, little i
Externí odkaz:
https://doaj.org/article/706e06d839d7477c90d137d87c35c527
Autor:
Keiji Furuuchi, Toshimitsu Uenaka, Ryoji Kato, Hitomi Sakai, Yuta Onodera, Elizabeth B. Somers, Hisato Kawakami, Takeshi Teramura, Kazuhiko Nakagawa
Publikováno v:
Clinical and Translational Medicine
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Background The main function of folate receptor α (FOLRα) has been considered to mediate intracellular folate uptake and induce tumor cell proliferation. Given the broad spectrum of expression among malignant tumors, including gastric cancer (GC) b
Autor:
Xochiquetzal J. Geiger, Edith A. Perez, Minetta C. Liu, Bahaaeldin Youssef, Fergus J. Couch, Mei Yin C. Polley, Brian M. Necela, Kathryn J. Ruddy, Krishna R. Kalari, Jodi M. Carter, James N. Ingle, Heshan Liu, Matthew P. Goetz, Nadine Norton, Elizabeth B. Somers, Keith L. Knutson, Aziza Nassar, David W. Hillman, Judy C. Boughey, Daniel W. Visscher, Roberto A. Leon-Ferre
Publikováno v:
npj Breast Cancer, Vol 6, Iss 1, Pp 1-9 (2020)
NPJ Breast Cancer
NPJ Breast Cancer
Triple negative breast cancer (TNBC) comprises 15–20% of all invasive breast cancer and is associated with a poor prognosis. As therapy options are limited for this subtype, there is a significant need to identify new targeted approaches for TNBC p
Autor:
Erin N. Ross, J. Bradford Kline, Luigi Grasso, Nicholas C. Nicolaides, Charles Schweizer, Wenquan Wang, Elizabeth B. Somers, Shawn Fernando, Raffit Hassan
Publikováno v:
Cancer Biology & Therapy
The tumor-shed antigen CA125 has recently been found to bind certain monoclonal antibodies (mAbs) and suppress immune-effector mediated killing through perturbation of the Fc domain with CD16a and CD32a Fc-γ activating receptors on immune-effector c
Autor:
Jennifer M. McDonough, Luigi Grasso, Charles Schweizer, Elizabeth B. Somers, Wenquan Wang, Katherine Rybinski, Nicholas C. Nicolaides, Shawn Fernando, Rina P. Kennedy, Earl Albone, James Bradford Kline, Qimin Chao
Publikováno v:
Oncotarget
// James Bradford Kline 1 , Rina P. Kennedy 1 , Earl Albone 1 , Qimin Chao 1 , Shawn Fernando 1 , Jennifer M. McDonough 1 , Katherine Rybinski 1 , Wenquan Wang 1 , Elizabeth B. Somers 1 , Charles Schweizer 1 , Luigi Grasso 1 and Nicholas C. Nicolaide
Autor:
Charles Schweizer, Nicholas C. Nicolaides, Rhonda Meredith, Wenquan Wang, Katie Bendas, Elizabeth B. Somers, Luigi Grasso, Mark Landers, Earl Albone, Jason Wustner, Daniel J. O'Shannessy, Susan C. Weil
Publikováno v:
Genomics. 109:251-257
Farletuzumab (FAR) is a humanized monoclonal antibody (mAb) that binds to folate receptor alpha. A Ph3 trial in ovarian cancer patients treated with carboplatin/taxane plus FAR or placebo did not meet the primary statistical endpoint. Subgroup analys
Autor:
Patrik F. Viana, Diogo Cavalcanti Cabral-de-Mello, Satz Mengensatzproduktion, Eliana Feldberg, Charles Schweizer, W. Feichtinger, Nicholas C. Nicolaides, Daniel J. O'Shannessy, Erin N. Ross, Susan C. Weil, Luigi Grasso, Octavio M. Palacios-Gimenez, Druckerei Stückle, Neide Santos, Wenquan Wang, José F. de Souza e Sousa, Claus Steinlein, J. Bradford Kline, Luiz Antonio Carlos Bertollo, Indrajit Nanda, Carolina Barros Machado, Vilma Loreto, Marcelo de Bello Cioffi, Elizabeth B. Somers, Andrezza C.S. Bernardino, Michael Schmid
Publikováno v:
Cytogenetic and Genome Research. 152:I-IV
Autor:
Erin N. Ross, J. Bradford Kline, Luigi Grasso, Charles Schweizer, Susan C. Weil, Wenquan Wang, Nicholas C. Nicolaides, Daniel J. O'Shannessy, Elizabeth B. Somers
Publikováno v:
Cytogenetic and Genome Research. 152:169-179
Farletuzumab is a humanized monoclonal antibody that binds to folate receptor alpha and elicits an anti-tumor response via immune effector activity. Recent studies from a global phase 3 trial in ovarian cancer patients treated with carboplatin/taxane