Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Elizabeth B. Hollingsworth"'
Publikováno v:
Journal of Medicinal Chemistry. 36:3417-3423
Several conformationally restricted derivatives of (S)-3-bromo-N-((1-ethyl-2-pyrrolidinyl)methyl)-2,6-dimethoxybenzamide (remoxipride) were synthesized and evaluated in vitro for their ability to inhibit [3H]raclopride binding at the dopamine D-2 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd7da8f3fecf0096eed8ec79cac52be
https://doi.org/10.1021/jm00074a023
https://doi.org/10.1021/jm00074a023
Autor:
Bernard T. Kenney, Robert M. Ferris, Nariman B. Mehta, F. E. Soroko, Elizabeth B. Hollingsworth, David Lee Musso
Publikováno v:
Chirality. 5:495-500
The synthesis of the enantiomers of bupropion, (rac)-2-tert-butylamino-3′-chloropropiophenone 1 (Wellbutrin®) is described. The enantiomers were compared with the racemate in both the tetrabenazine-induced sedation model and the inhibition of upta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18518f98e7a8951a6d8c0c468f0ef3b7
https://doi.org/10.1002/chir.530050704
https://doi.org/10.1002/chir.530050704
Publikováno v:
Journal of Neurochemistry. 59:1459-1466
Systemic administration of ritanserin elicited rapid changes in dopamine (DA) and serotonin (5-HT) levels in both dialysate and neuronal tissue extracts. These effects occurred in both a site-selective and a dose-related manner. Increases in extracel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bcaf4f49eeb340deae5dbb022b463c
https://doi.org/10.1111/j.1471-4159.1992.tb08461.x
https://doi.org/10.1111/j.1471-4159.1992.tb08461.x
Publikováno v:
European journal of pharmacology. 192(3)
The effects of acute ritanserin treatment on dopamine (DA) and serotonin (5-HT) release and metabolism were studied in tissue and microdialysis samples of the nucleus accumbens in rats. Administration of a moderate dose of ritanserin elicited decreas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60157e70de4cb89cd134210baf8c5586
https://pubmed.ncbi.nlm.nih.gov/1675992
https://pubmed.ncbi.nlm.nih.gov/1675992
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 930:272-278
Activation of protein kinase C by phorbol esters such as phorbol 12-myristate 13-acetate (PMA), modulates responsiveness of the cyclase system in many cell types. In the neuroblastoma-hybrid cell line NCB-20, PMA causes a reduction in receptor-mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e872e9e3e88cd4de34bede07af5a6ac
https://doi.org/10.1016/0167-4889(87)90040-1
https://doi.org/10.1016/0167-4889(87)90040-1
Publikováno v:
Pharmacology Biochemistry and Behavior. 22:365-370
In the present study, the depressant and sedative actions of prostaglandin D2 (PGD2) were investigated. Intravenous (IV) administration of PGD2 produced a significant decrease in the spontaneous locomotor activity of mice from 1 to 15 minutes followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f49c818be8e344e87dbf1fb640cc53c
https://doi.org/10.1016/0091-3057(85)90033-4
https://doi.org/10.1016/0091-3057(85)90033-4
Publikováno v:
Pharmacology Biochemistry and Behavior. 22:371-375
In earlier studies, it was proposed that there was a serotonergic involvement in the ability of prostaglandin D 2 (PGD 2 ) to potentiate pentobarbital sleeping time. The actions of PGD 2 on neuronal turnover and release of serotonin and uptake of try
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685c904ce2f0790c3cc568240916a988
https://doi.org/10.1016/0091-3057(85)90034-6
https://doi.org/10.1016/0091-3057(85)90034-6
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 883:15-25
Activation of α 1 -adrenergic receptors by norepinephrine in guinea pig cortical synaptoneurosomes augments accumulations of cyclic AMP elicited by 2-chloroadenosine and concomitantly increases formation of inositol phosphates. Various agents that e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159dfd1326fd063b57f3989270a63ea5
https://doi.org/10.1016/0304-4165(86)90129-7
https://doi.org/10.1016/0304-4165(86)90129-7
Publikováno v:
FEBS Letters. (1):193-196
The effects of various barbiturates and picrotoxin in modifying the efflux of chloride (36Cl-) was studied in a novel subcellular preparation from rat cerebral cortex, the 'synaptoneurosome'. Dilution of synaptoneurosomes pre-loaded with 36Cl- result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33da9f7361f1c71a2c85fd56c23506eb
Publikováno v:
FEBS letters. 184(2)
Norepinephrine and histamine markedly augment accumulations of cyclic AMP elicited by 2-chloroadenosine in a guinea pig cerebral cortical vesicular preparation. In addition, these biogenic amines stimulate phosphatidylinositol turnover. Phosphatidyli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d59f46a65026b02c4ebfab54a39225a
https://pubmed.ncbi.nlm.nih.gov/2987034
https://pubmed.ncbi.nlm.nih.gov/2987034